Publikationen der Abteilung Biostatistik

Rezensierte Zeitschriften

  • Menssen M, Schaarschmidt F (2019) Prediction intervals for overdispersed binomial data with application to historical controlsStatistics in Medicine 18(3)275-398
    DOI: 10.1002/sim.8124
  • Klaus A, Strube C, Röper KM, Radespiel U, Schaarschmidt F, Nathan S, Goossens B, Zimmermann E (2018) Fecal parasite risk in the endangered proboscis monkey is higher in an anthropogenically managed forest environment compared to a riparian rain forest in Sabah, BorneoPLOS ONE
    DOI: 10.1371/journal.pone.0195584
  • Klein A, Zimmerman E, Radespiel, U, Schaarschmidt F, Springer A, Strube C (2018) Ectoparasite communities of small-bodied Malagasy primates: seasonal and socioecological influences on tick, mite and lice infestation of Microcebus murinus and M. ravelobensis in northwestern MadagascarParasites & Vectors 11
    DOI: 10.1186/s13071-018-3034-y
  • Sybertz J, Matthies A, Schaarschmidt F, Reich M, von Haaren C (2018) Assessing the value of field margins for butterflies and plants: how to document and enhance biodiversity at the farm scaleAgriculture, Ecosystems and Environment 249, 165-176
    DOI: 10.1016/j.agee.2017.08.018
  • Baeßler B, Schaarschmidt F, Treutlein M, Stehning C, Schnackenburg B, Michels G, Maintz D, Bunck AC (2017) Re-evaluation of a novel approach for quantitative myocardial edema detection by analyzing tissue inhomogeneity in acute myocarditis using T2-mappingEuropean Radiology 27 (12)
    DOI: 10.1007/s00330-017-4894-9
  • Jensen SM, Schaarschmidt F, Onofri A, Ritz C (2017) Experimental design matters for statistical analysis: how to handle blockingPest Management Science 74(3), 523-534
    DOI: 10.1002/ps.4773
  • Khamis G, Schaarschmidt F, Papenbrock J (2017) Genetic diversity among populations of the xerophytic tree species Balanites aegyptiaca and its morpho-physiological responses to water deficiencyAfrican Journal of Agricultural Research 12(45): 3252-3269
    DOI: 10.5897/AJAR2017.12696
  • Matthies SA, Rüter S, Schaarschmidt F, Prasse R (2017) Determinants of species richness within and across taxonomic groups in urban green spacesUrban Ecosystems 20: 897-909
    DOI: 10.1007/s11252-017-0642-9
  • Menssen M, Linde M, Otunga Omondi E, Abukutsa-Onyango M, Dinssa FF, Winkelmann T (2017) Genetic and morphological diversity of cowpea (Vigna unguiculata (L.) Walp.) entries from East AfricaScientia Horticulturae 226: 268–276
    DOI: 10.1016/j.scienta.2017.08.003
  • Otava M, Sengupta R, Shkedy Z, Hothorn LA, Gerhard D (2017) IsoGeneGUI: Multiple Approaches for Dose-Response Analysis of Microarray Data Using RR JOURNAL Volume: 9 Issue: 1 Pages: 14-26
  • Otava M, Shkedy Z, Hothorn LA, Talloen W, Gerhard D, Kasim A (2017) Identification of the Minimum Effective Dose for Normally Distributed Data Using a Bayesian Variable Selection ApproachJournal of Biopharmaceutical Statistics
    DOI: 10.1080/10543406.2017.1295247
  • Schaarschmidt F (2017) Multiple treatment comparisons in analysis of covariance with interactionStatistical Methods and Applications 26, 609-628
    DOI: 10.1007/s10260-017-0383-1
  • Turner S, Meyer-Stüve S, Schippers A, Guggenberger G, Schaarschmidt F, Wild B, Richter A, Dohrmann R, Mikutta R (2017) Microbial utilization of mineral-associated nitrogen in soilsSoil Biology and Biochemistry 104, 185–196
    DOI: 10.1016/j.soilbio.2016.10.010
  • Turner S, Mikutta R, Meyer-Stüve S, Guggenberger G, Schaarschmidt F, Lazar CS, Dohrmann R, Schippers A (2017) Microbial Community Dynamics in Soil Depth Profiles Over 120,000 Years of Ecosystem DevelopmentFront. Microbiol. 8:874
    DOI: 10.3389/fmicb.2017.00874
  • Baeßler B, Schaarschmidt F, Stehning C, Schnackenburg B, Giolda A, Maintz D, Bunck AC (2016) Reproducibility of three different cardiac T2 -mapping sequences at 1.5TJ Magn Reson Imaging. 44(5)
    DOI: 10.1002/jmri.25258
  • Baessler B, Schaarschmidt F, Dick A, Michels G, Maintz D, Bunck AC (2016) Diagnostic implications of magnetic resonance feature tracking derived myocardial strain parameters in acute myocarditisEuropean Journal of Radiology 85(1), 218-227
    DOI: 10.1016/j.ejrad.2015.11.023
  • Bischoff N, Mikutta R, Shibistova O, Puzanov A, Reichert E, Silanteva M, Grebennikova A, Schaarschmidt F, Heinicke S, Guggenberger G (2016) Land-use change under different climatic conditions: Consequences for organic matter and microbial communities in Siberian steppe soilsAgriculture, Ecosystems & Environment 235, 253–264
    DOI: 10.1016/j.agee.2016.10.022
  • Große Ruse M, Ritz C, Hothorn LA (2016) Simultaneous inference of a binary composite endpoint and its componentsJournal of Biopharmaceutical Statistics
    DOI: 10.1080/10543406.2016.1148704
  • Hohenbrink S, Schaarschmidt F, Bünemann K, Gerberding S, Zimmermann E, Radespiel U (2016) Female dominance in two basal primates, Microcebus murinus and Microcebus lehilahytsara: variation and determinantsAnimal Behaviour 122, 145-156
    DOI: 10.1016/j.anbehav.2016.10.008
  • Hothorn LA (2016) The two-step approach - a significant ANOVA F-test before Dunnett's comparisons against a control - is not recommendedCommunications in Statistics - Simulation and Computation
    DOI: 10.1080/03610926.2014.902225
  • Khamis G, Winkelmann T, Schaarschmidt F, Papenbrock J (2016) Establishment of an in vitro propagation and transformation system of Balanites aegyptiacaPlant Cell Tissue & Organ Culture 125, 3, 457–470
    DOI: 10.1007/s11240-016-0961-1
  • Kitsche A, Ritz C, Hothorn LA (2016) A General Framework for the Evaluation of Genetic Association Studies Using Multiple Marginal ModelsHum Hered 81:150-172
    DOI: 10.1159/000448477
  • Leinemann T, Mikutta R, Kalbitz K, Schaarschmidt F, Guggenberger G (2016) Small scale variability of vertical water and dissolved organic matter fluxes in sandy Cambisol subsoils as revealed by segmented suction platesBiogeochemistry 131, 1-15
    DOI: 10.1007/s10533-016-0259-8
  • Pallmann P, Hothorn LA (2016) Analysis of means (ANOM): a generalized approach using RJournal of Applied Statistics
    DOI: 10.1080/02664763.2015.1117584
  • Pallmann P, Schaarschmidt F (2016) Common pitfalls when testing additivity of treatment mixtures with chi-square analysesJournal of Applied Entomology 140 (1-2), 135–141
    DOI: 10.1111/jen.12258
  • Santiago J, Brandt B, Wildhagen M, Hohmann U, Hothorn LA, Butenko MA, Hothorn M (2016) Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscissioneLife
    DOI: 10.7554/eLife.15075
  • Schaarschmidt F, Djira GD (2016) Simultaneous confidence intervals for ratios of fixed effect parameters in linear mixed modelsCommunications in Statistics – Simulation and Computation 45: 1704–1717
    DOI: 10.1080/03610918.2013.849741
  • Schaarschmidt F, Gerhard D, Vogel C (2016) Simultaneous confidence intervals for comparisons of several multinomial samplesComputational Statistics and Data Analysis 106, 65-76
    DOI: 10.1016/j.csda.2016.09.004
  • Baeßler B, Schaarschmidt F, Dick A, Stehning C, Schnackenburg B, Michels G, Maintz D, Bunck AC (2015) Mapping tissue inhomogeneity in acute myocarditis: a novel analytical approach to quantitative myocardial edema imaging by T2-mappingJournal of Cardiovascular Magnetic Resonance. 17:115
    DOI: 10.1186/s12968-015-0217-y
  • Baeßler B, Schaarschmidt F, Schnackenburg B, Stehning C, Giolda A, Maintz D, Bunck AC (2015) Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experiencesJournal of Cardiovascular Magnetic Resonance. 17:67
    DOI: 10.1186/s12968-015-0177-2
  • Baeßler B, Schaarschmidt F, Stehning C, Schnackenburg B, Maintz D, Bunck AC (2015) A Systematic Evaluation of Three Different Cardiac T2-mapping Sequences at 1.5 and 3T in Healthy VolunteersEuropean Journal of Radiology 84(11): 2161-70
    DOI: 10.1016/j.ejrad.2015.08.002
  • Bredemeier B, von Haaren C, Rüter S, Schaarschmidt F, Reich M (2015) Spatial congruence between organic farming and biodiversity related landscape features in GermanyInternational Journal of Biodiversity Science, Ecosystem Services & Management 11(4) 330-340
    DOI: 10.1080/21513732.2015.1094515
  • Karanja J, Poehling HM, Pallmann P (2015) Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter in the control of whiteflies Aleyrodes proletella and Trialeurodes vaporariorum (Hemiptera: Aleyrodidae)Journal of Economic Entomology 108(3)1182–1190
    DOI: 10.1093/jee/tov047
  • Kitsche A, Schaarschmidt F (2015) Analysis of Statistical Interactions in Factorial ExperimentsJournal of Agronomy and Crop Science 201(1): 69-79.
    DOI: 10.1111/jac.12076
  • Konietschke F, Placzek M, Schaarschmidt F, Hothorn LA (2015) nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence IntervalsJournal of Statistical Software 64(9)
    DOI: 10.18637/jss.v064.i09
  • Matthies S, Rüter S, Prasse R, Schaarschmidt F (2015) Factors driving the vascular plant species richness in urban green spaces: Using a multivariable approachLandscape and Urban Planning
    DOI: 10.1016/j.landurbplan.2014.10.014
  • Pallmann P, Hothorn LA (2015) Boxplots for grouped and clustered data in toxicologyArch Tox
    DOI: 10.1007/s00204-015-1608-4
  • Radespiel U, Schaber K, Kessler SE, Schaarschmidt F, Strube C (2015) Variations in the excretion patterns of helminth eggs in two sympatric mouse lemur species (Microcebus murinus and M. ravelobensis) in northwestern MadagascarParasitology Research 114 (3): 941-954
    DOI: 10.1007/s00436-014-4259-0
  • Schaarschmidt F (2015) Confidence Intervals for the Risk Ratio when Analyzing Bioassays in the Presence of OverdispersionBiometrics and Biostatistics International Journal 2015, 2(7)
    DOI: 10.15406/bbij.2015.02.00050
  • Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA (2015) Statistical approaches for the determination of cut points in anti-drug antibody bioassaysJournal of Immunological Methods 418, 84–100
    DOI: 10.1016/j.jim.2015.02.004
  • Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA (2015) Statistical approaches for the determination of cut points in anti-drug antibody bioassaysJournal of Immunological Methods
    DOI: 10.1186/s12968-015-0177-2
  • Weese A, Pallmann P, Papenbrock J, Riemenschneider A (2015) Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attackFrontiers in Plant Science, 6:9
    DOI: 10.3389/fpls.2015.00009
  • Wimalasekera R, Schaarschmidt F, Angelini R, Cona A, Tavladoraki P, Scherer GFE (2015) POLYAMINE OXIDASE2 of Arabidopsis Contributes to ABA Mediated Plant Developmental ProcessesPlant Physiology and Biochemistry 96:231-240
    DOI: 10.1016/j.plaphy.2015.08.003
  • Bohne H, Wanjiku J, Rathke A-K, Humpert S, Gerhard D (2014) Influence of Nutrient Loading on Growth, N-, P-, and K-Concentrations and Outplanting Performance of Rosa majalisEuropean Journal of Horticultural Science 79(1):29-35
    ISBN: ISSN 1611-4426
  • Gerhard D (2014) Simultaneous Small Sample Inference For Linear Combinations Of Generalized Linear Model ParametersCommunications in Statistics - Simulation and Computation 45(8)2678-2690
    DOI: 10.1080/03610918.2014.895836
  • Gerhard D, Bremer M, Ritz C (2014) Estimating marginal properties of quantitative real-time PCR data using nonlinear mixed modelsBiometrics 70(1):247-254
    DOI: 10.1111/biom.12124
  • Graf N, Dinkel B, Rose H, Hothorn LA, Gerhard D, Johansen P, Kundig TM, Klimek L, Senti G (2014) A critical appraisal of analyzing nasal provocation test results in allergen immunotherapy trialsRhinology 52(2):137-141
    DOI: 10.4193/Rhin
  • Hothorn LA (2014) Statistical evaluation of toxicological bioassays –a reviewToxicology Research 3:418-432
    DOI: 10.1039/c4tx00047a
  • Jaki Th, Kitsche A, Hothorn LA (2014) Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control groupJP Journal of Biostatistics 11(1):1-32
  • Kitsche A (2014) Detecting qualitative interactions in clinical trials with binary responsesPharmaceutical Statistics 13(5): 309-315
    DOI: 10.1002/pst.1632
  • Kitsche A, Hothorn LA (2014) Testing for qualitative interaction using ratios of treatment differencesStatistics in Medicine 33(9):1477-1489
    DOI: 10.1002/sim.6048
  • Kuiper RM, Gerhard D, Hothorn LA (2014) Identification of the Minimum Effective Dose for Normally Distributed Endpoints Using a Model Selection ApproachStatistics in Biopharmaceutical Research 6(1):55-66
    DOI: 10.1080/10543406.2017.1295247
  • Pallmann P (2014) Book review: Applied meta-analysis with RJournal of Applied Statistics 42(4): 914-919
    DOI: 10.1080/02664763.2014.989464
  • Pallmann P, Hothorn LA, Djira GD (2014) A Levene-type test of homogeneity of several variances against ordered alternativesComputational Statistics 29(6): 1593-1608
    DOI: 10.1007/s00180-014-0508-z
  • Schaarschmidt F, Hothorn LA (2014) Statistical Methods and Software for Validation Studies on New In Vitro Toxicity AssaysATLA 42:319-329
  • Hasler M, Hothorn LA (2013) Simultaneous confidence intervals on multivariate non-inferiorityStatistics in Medicine, 32(10) 1720-1729
    DOI: 10.1002/sim.5633
  • Herberich E, Hothorn LA (2013) A Maximum-Type Association Test for Censored Time-to-Event DataJournal of Biometrics & Biostatistics, 4: 178
    DOI: 10.4172/2155-6180.1000178
  • Hothorn LA, Reisinger K, Wolf T, Poth A, Fieblinger D, Liebsch M, Pirow R (2013) Statistical analysis of the hens egg test for micronucleus induction (HET-MN Assay)Mutation Research, 757(1)68-78
    DOI: 10.1016/j.mrgentox.2013.04.023
  • Jaki T, Hothorn LA (2013) Statistical evaluation of toxicological assays: Dunnett or Williams test- take bothArchives of Toxicology, 87:1901-1910
    DOI: 10.1007/s00204-013-1065-x
  • Jaki T, Pallmann P, Wolfsegger MJ (2013) Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designsStatistics in Medicine 32(30): 5469-5483
    DOI: 10.1002/sim.5886
  • Jaki T, Pallmann P, Wolfsegger MJ (2013) Authors' reply to Comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs"Statistics in Medicine 32(30): 5487-5488
    DOI: 10.1002/sim.6000
  • Kitsche A, Kalesse M (2013) Configurational Assignment of Secondary Hydroxyl Groups and Methyl Branches in Polyketide Natural Products through Bioinformatic Analysis of the Ketoreductase DomainChemBioChem 14(7):851-61
    DOI: 10.1002/cbic.201300063
  • Konietschke F, Bösiger S, Brunner E, Hothorn LA (2013) Are Multiple Contrasts Tests superior to the ANOVA?International Journal of Biostatistics
    DOI: 10.1515/ijb-2012-0020
  • Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn LA, Bremer S, van Thriel C, Krause K-H, Hengstler JG, Rahnenführer J (2013) Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approachArchives of Toxicology 87(1):123-143
    DOI: 10.1007/s00204-012-0967-3
  • Loley C, König I, Hothorn LA, Ziegler A (2013) A unifying framework for robust association testing, estimation and genetic model selection using the generalized linear modelEuropean Journal of Human Genetics 21, 12; 1442-1448
    DOI: 10.1038/ejhg.2013.62
  • Maurer W, Bretz F (2013) Memory and other properties of multiple test procedures generated by entangled graphsStatistics in Medicine V32(10)1739-1753
    DOI: 10.1002/sim.5711
  • Priesnitz K-U, Benker U, Schaarschmidt F (2013) Assessment of the potential impact of a Bt maize hybrid expressing Cry3Bb1 on ground beetles (Carabidae)Journal of Plant Diseases and Protection 120 (3), 131–140
    DOI: 10.1007/BF03356464
  • Ritz C, Gerhard D, Hothorn LA (2013) A unified framework for benchmark dose estimation applied to mixed models and model averagingStatistics in Biopharmaceutical Research 5(1):79-90
    DOI: 10.1080/19466315.2012.757559
  • Schaarschmidt, F. (2013) Simultaneous confidence intervals for multiple comparisons among expected values of log-normal variablesComputational Statistics and Data Analysis 58, 265–275.
    DOI: 10.1016/j.csda.2012.08.011
  • Scherer R, Schaarschmidt F, Prescher S, Priesnitz KU (2013) Simultaneous confidence intervals for comparing biodiversity indices estimated from overdispersed count dataBiometrical Journal 55 (2), 246–263
    DOI: 10.1002/bimj.201200157
  • Schlingmann B, Schadzek P, Hemmerling F, Schaarschmidt F, Heisterkamp A, Ngezahayo A (2013) The role of the C-terminus in functional expression and internalization of rat connexin46 (rCx46)J Bioenerg Biomembr 45:59-70
    DOI: 10.1007/s10863-012-9480-x
  • Bohne H, Kluge K, Amha Y, Gerhard D (2012) Influence of peats of different origins and decomposition degree on germination and early growth of Chinese cabbageEuropean Journal of Horticultural Science 77(5):211-218
  • Hasler M, Hothorn LA (2012) A multivariate Williams-type trend procedureStatistics in Biopharmaceutical Research 4:57-65
    DOI: 10.1080/19466315.2011.633868
  • Herberich E, Hothorn LA (2012) Statistical evaluation of mortality in long-term carcinogenicity bioassays using a Williams-type procedureRegulatory Toxicology and Pharmacology 64(1):26-34
    DOI: 10.1016/j.yrtph.2012.06.014
  • Hoffmann S, Hothorn LA, Edler L, Kleensang A, Suzuki M, Phrakonkham P, Gerhard D (2012) Two new approaches to improve the analysis of BALB/c 3T3 cell transformation assay dataMutation Research - Genetic Toxicology and Environmental Mutagenesis 744(1):36-41
    DOI: 10.1016/j.mrgentox.2011.12.002
  • Hothorn LA, Libiger O, Gerhard D (2012) Model-specific tests on variance heterogeneity for detection of potentially interacting genetic lociBMC Genetics 13:59
    DOI: 10.1186/1471-2156-13-59
  • Kitsche A, Schaarschmidt F, Hothorn LA (2012) The use of historical controls in estimation of simultaneous confidence intervals for comparisons against a concurrent controlComputational Statistics and Data Analysis 56(12):3865-3875
    DOI: 10.1016/j.csda.2012.05.010
  • Konietschke F, Hothorn LA (2012) Evaluation of toxicological studies using a non-parametric Shirley-type trend test for comparing several dose levels with a control groupStatistics in Biopharmaceutical Research 4:14-27
    DOI: 10.1080/19466315.2011.633861
  • Konietschke F, Hothorn LA, Brunner E (2012) Rank-based multiple test procedures and simultaneous confidence intervalsElectronic Journal of Statistics 6:737-759
    DOI: 10.1214/12-EJS691
  • Konietschke F, Libiger O, Hothorn LA (2012) Nonparametric Evaluation of Quantitative Traits in Population-Based Association Studies when the Genetic Model is UnknownPLoS ONE 7(2):e31242
    DOI: 10.1371/journal.pone.0031242
  • Pallmann P, Schaarschmidt F, Hothorn LA, Fischer C, Nacke H, Priesnitz KU, Schork NJ (2012) Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indicesMolecular Ecology Resources 12(6): 1068-1078
    DOI: 10.1111/1755-0998.12004
  • Senti G, Crameri R, Kuster D, Johansen P, Martinez-Gomez JM, Graf N, Steiner M, Hothorn LA, Grönlund H, Tivig C, Zaleska A, Soyer O, van Hage M, Akdis CA, Akdis M, Rose H, Kündig TM (2012) Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injectionsJournal of Allergy and Clinical Immunology 129(5):1290-1296
    DOI: 10.1016/j.jaci.2012.02.026
  • Strohmaier J, Amelang M, Hothorn LA, Witt SH, Nieratschker V, Gerhard D, Meier S, Wüst S, Frank J, Loerbroks A, Rietschel M, Stürmer T, Schulze TG (2012) The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general populationMolecular Psychatry 18(5):607-613
    DOI: 10.1038/mp.2012.53
  • Bohne H, Salomon L, Gerhard D (2011) Influence of provenance and fertilization in the tree nursery on outplanting performance and N-, P-, and K-content of Viburnum opulus L. in shoots and rootsJournal of Environmental Horticulture 29(3):137-142
    DOI: 10.24266/0738-2898-29.3.137
  • Bunck AC, Kröger J-R, Juettner A, Brentrup A, Fiedler B, Schaarschmidt F, Crelier G, Schwindt W, Heindel W, Niederstadt T, Maintz D (2011) Magnetic resonance 4D flow characteristics of cerebrospinal fluid at the craniocervical junction and the cervical spinal canalEuropean Radiology 21(8)1788–1796
    DOI: 10.1007/s00330-011-2105-7
  • Hasler M, Hothorn LA (2011) A Dunnett-Type Procedure for Multiple EndpointsThe International Journal of Biostatistics 7(1):3-3
    DOI: 10.2202/1557-4679.1258
  • Hirotsu C, Yamamoto S, Hothorn LA (2011) Estimating the Dose-Response Pattern by the Maximal Contrast Type Test ApproachStatistics in Biopharmaceutical Research 3(1)40-53
    DOI: 10.1198/sbr.2010.08093
  • Hothorn LA, Djira GD (2011) A ratio-to-control Williams-type test for trendPharmaceutical Statistics 10(4):289-292
    DOI: 10.1002/pst.464
  • Selig M, Bohne H, Gerhard D (2011) Influence of refertilization of Salix cinerea L. in late summer on early frost hardiness and on some nutrients and biomarkerGesunde Pflanzen 63(3):129-133
    DOI: 10.1007/s10343-011-0256-8
  • Bilder CR, Zhang B, Schaarschmidt F, Tebbs JM (2010) binGroup: A Package for Group TestingThe R Journal 2/2, 56-60
  • Djira GD, Schaarschmidt F, Fayissa B (2010) Inferences for Selected Location Quotients with Applications to Health OutcomesGeographical Analysis 42(3)288-300
    DOI: 10.1111/j.1538-4632.2010.00794.x
  • Gerhard D, Hothorn LA (2010) Rank transformation in Haseman-Elston regression using scores for location-scale alternativesHuman Heredity 69(3):143-151
    DOI: 10.1159/000267994
  • Hothorn LA, Sill M, Schaarschmidt F (2010) Evaluation of Incidence Rates in Pre-Clinical Studies Using a Williams-Type ProcedureThe International Journal of Biostatistics 6(1):15
    DOI: 10.2202/1557-4679.1180
  • Hothorn LA, Vohr HW (2010) Statistical Evaluation of the Local Lymph Node AssayRegulatory Toxicology and Pharmacology 56(3):352-356
    DOI: 10.1016/j.yrtph.2009.10.007
  • Konietschke F, Bathke AC, Hothorn LA, Brunner E (2010) Testing and estimation of purely nonparametric effects in repeated measures designsComputational Statistics and Data Analysis 54:1895-1905
    DOI: 10.1016/j.csda.2010.02.019
  • Menke S, Gerhard D (2010) Detection of a related difference in efficacy of azadirachtin treatments for the control of whiteflies on Gerbera jamesonii by testing for interactions in generalised linear modelsPest Management Science 66(4):358-364
    DOI: 10.1002/ps.1881
  • Rauschen S, Schaarschmidt F, Gathmann A (2010) Occurrence and field densities of Coleoptera in the maize herb layer: implications for Environmental Risk Assessment of genetically modified Bt-maizeTransgenic Research 19:727-744
    DOI: 10.1007/s11248-009-9351-3
  • Rauschen S, Schultheis E, Hunfeld H, Schaarschmidt F, Schuphan I, Eber S (2010) Diabrotica-resistant Bt-maize DKc5143 event MON88017 has no impact on the field densities of the leafhopper Zyginidia scutellarisEnvironmental Biosafety Research 9, 87–99
    DOI: 10.1051/ebr/2010012
  • Zimmermann H, Gerhard D, Dingermann T, Hothorn LA (2010) Statistical aspects of design and validation of microtitre-plate-based linear and non-linear parallel in vitro bioassaysBiotechnology Journal 5(1):62-74
    DOI: 10.1002/biot.200900146
  • Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010) An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 1Pharmazeutische Industrie 72(4):708-712
  • Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010) An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 2Pharmazeutische Industrie 72(5):884-895
  • Acutis M, Hothorn LA, McNicol J, van der Voet H (2009) Statistical considerations for the safety evaluation of GMOsEFSA Journal 1250:1
    DOI: 10.2903/j.efsa.2010.1250
  • Djira GD, Hothorn LA (2009) Detecting Relative Changes in Multiple Comparisons with an Overall MeanJournal of Quality Technology 41(1):60-65
    DOI: 10.1080/00224065.2009.11917760
  • Hothorn LA, Gerhard D (2009) Statistical evaluation of the in vivo micronucleus assayArchives of Toxicology 83(6):625-634
    DOI: 10.1007/s00204-008-0393-8
  • Hothorn LA, Gerhard D, Hofmann M (2009) Parametric and non-parametric prediction intervals based phase II control charts for repeated bioassay dataBiologicals 37(5): 323-330
    DOI: 10.1016/j.biologicals.2009.07.001
  • Hothorn LA, Hothorn T (2009) Order-restricted Scores Test for the Evaluation of Population based Case–control Studies when the Genetic Model is UnknownBiometrical Journal 51(4):659-669
    DOI: 10.1002/bimj.200800203
  • Hothorn LA, Vaeth M, Hothorn T (2009) Trend tests for the evaluation of exposure-response relationships in epidemiological exposure studiesEpidemiologic Perspectives & Innovations 6:1
    DOI: 10.1186/1742-5573-6-1
  • Perry JN, ter Braak CJF, Dixon PM, Duan JJ, Hails RS, Huesken A, Lavielle M, Marvier M, Scardi M, Schmidt K, Tothmeresz B, Schaarschmidt F, van der Voet H (2009) Statistical aspects of environmental risk assessment of GM plants for effects on non-target organismsEnvironmental Biosafety Research 8:65-78
    DOI: 10.1051/ebr/2009009
  • Schaarschmidt F, Biesheuvel E, Hothorn LA (2009) Asymptotic Simultaneous Confidence Intervals for Many-to-One Comparisons of Binary Proportions in Randomized Clinical TrialsJournal of Biopharmaceutical Statistics 19:292-310
    DOI: 10.1080/10543400802622501
  • Schaarschmidt F, Vaas L (2009) Analysis of trials with complex treatment structure using multiple contrast testsHortScience 44(1):188-195
    DOI: 10.21273/HORTSCI.44.1.188
  • Braat S, Gerhard D, Hothorn LA (2008) Joint one-sided and two-sided simultaneous confidence intervalsJournal of Biopharmaceutical Statistics. 18(2):293-306
    DOI: 10.1080/10543400701697174
  • Dilba G, Hothorn LA, Tsong Y (2008) Equivalence Tests for Shelf Life and Average Drug Content in Stability StudiesJournal of Biopharmaceutical Statistics 18(5):985-995
    DOI: 10.1080/10543400802287230
  • Froemke C, Hothorn LA, Kropf S (2008) Nonparametric relevance-shifted multiple testing procedures for the analysis of high-dimensional multivariate data with small sample sizesBMC Bioinformatics 9:54
    DOI: 10.1186/1471-2105-9-54
  • Hasler M, Hothorn LA (2008) Multiple Contrast Tests in the Presence of HeteroscedasticityBiometrical Journal 50(5)793-800
    DOI: 10.1002/bimj.200710466
  • Hasler M, Vonk R, Hothorn LA (2008) Assessing non-inferiority of a new treatment in a three-arm trial in the presence of heteroscedasticityStatistics in Medicine 27:490-503
    DOI: 10.1002/sim.3052
  • Hothorn LA, Hasler M (2008) Proof of hazard and proof of safety in toxicological studies using simultaneous confidence intervals for differences and ratios to controlJournal of Biopharmaceutical Statistics 18(5)915-933
    DOI: 10.1080/10543400802287511
  • Hughes S (2008) European regulatory agencies should employ full time statisticiansBritish Medical Journal 336(7638):250
    DOI: 10.1136/bmj.39470.632951.59
  • Rauschen S, Eckert J, Schaarschmidt F, Schuphan I, Gathmann A (2008) An evaluation of methods for assessing the impacts of Bt-maize MON810 cultivation and pyrethroid insecticide use on Auchenorrhyncha (Planthoppers and Leafhoppers)Agricultural and Forest Entomology 10(4)331-339
    DOI: 10.1111/j.1461-9563.2008.00394.x
  • Schaarschmidt F, Sill M, Hothorn LA (2008) Approximate Simultaneous Confidence Intervals for Multiple Contrasts of Binomial ProportionsBiometrical Journal 50(5)782-792
    DOI: 10.1002/bimj.200710465
  • Schaarschmidt F, Sill M, Hothorn LA (2008) Poly-k-trend tests for survival adjusted analysis of tumor rates formulated as approximate multiple contrast testJournal of Biopharmaceutical Statistics 18(5)934-948
    DOI: 10.1080/10543400802294285
  • Schunkert H, Götz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Linsel-Nitschke P, Cambien F, Hengstenberg C, Stark K, Blankenberg S, Tiret L, Ducimetiere P, Keniry A, Ghori MJ, Schreiber S, El Mokhtari NE, Hall AS, Dixon RJ, Goodall AH, Liptau H, Pollard H, Schwarz DF, Hothorn LA, Wichmann HE, König IR, Fischer M, Meisinger C, Ouwehand W, Deloukas P, Thompson JR, Erdmann J, Ziegler A, Samani NJ; Cardiogenics Consortium (2008) Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery diseaseCirculation 117(13):1675-1684
    DOI: 10.1161/CIRCULATIONAHA.107.730614 PMCID: PMC2689930 EMSID: UKMS4596
  • Dilba G, Schaarschmidt F, Hothorn LA (2007) Inferences for ratios of normal meansR News 7(1):20-23
  • Hothorn LA (2007) How to deal with multiple treatment or dose groups in randomized clinical trials?Fundamental & Clinical Pharmacology 21(2):137-154
    DOI: 10.1111/j.1472-8206.2007.00469.x
  • Schaarschmidt F (2007) Experimental design for one-sided confidence intervals or hypothesis tests in binomial group testingCommunications in Biometry and Crop Science 2(1):32-40
  • Toschki A, Hothorn LA, Ross-Nickoll M (2007) Effects of cultivation of genetically modified Bt maize on epigeic arthropodsEnvironmental Entomology 36(4):967-981
    DOI: 10.1603/0046-225X(2007)36[967:EOCOGM]2.0.CO;2
  • Dilba G, Bretz F, Hothorn LA, Guiard V (2006) Power and sample size computations in simultaneous tests for non-inferiority based on relative marginsStatistics in Medicine 25(7):1131-1147
    DOI: 10.1002/sim.2359
  • Eckert J, Schuphan L, Hothorn LA, Gathmann A (2006) Arthropods on Maize Ears for Detecting Impacts of Bt Maize on Nontarget OrganismsEnvironmental Entomology 35:554-560
    DOI: 10.1603/0046-225X-35.2.554
  • Gathmann A, Wirooks L, Hothorn LA, Bartsch D, Schuphan I (2006) Impact of Bt maize pollen (MON810) on lepidopteran larvae living on accompanying weedsMolecular Ecology 15(9):2677-2685
    DOI: 10.1111/j.1365-294X.2006.02962.x
  • Hauschke D, Hothorn LA (2006) Letter to Editor: An introductory note to the CHMP guidelines: choice of the non-inferiority margin and data monitoring committees by David Brown, Peter Volkers and Simon DayStatistics in Medicine 25:1623-1627; Statistics in Medicine 26:230-236
    DOI: 10.1002/sim.2665
  • Hothorn LA (2006) Multiple comparisons and multiple contrasts in randomized dose-response trials - confidence interval orient approachesJournal of Biopharmaceutical Statistics 16(5)711-731
    DOI: 10.1080/10543400600860576
  • Hothorn LA (2006) Statistical analysis of in vivo anticancer experiments: Tumor growth inhibitionDrug Information Journal 40:229-238
    DOI: 10.1177/009286150604000212
  • Hothorn LA, Bleiholder H (2006) Statistical aspects of efficacy evaluation of plant protection products in field trials – a comment on EPPO Standard PP1/152EPPO Bulletin 36:31-45
    DOI: 10.1111/j.1365-2338.2006.00934.x
  • Hothorn LA, Oberdörfer R (2006) Statistical analysis used in the nutritional assessment of novel food using the proof of safetyRegulatory Toxicology and Pharmacology 44:125-135
    DOI: 10.1016/j.yrtph.2005.10.001
  • Neuhäuser M, Hothorn LA (2006) A robust modification of the ordered-heterogeneity testJournal of Applied Statistics 33(7)721-727
    DOI: 10.1080/02664760600708954
  • Dette H, Trampisch M, Hothorn LA (2005) Robust Designs in Noninferiority Three-Arm Clinical Trials With Presence of HeteroscedasticityStatistics in Biopharmaceutical Research 1(3):268-278
    DOI: 10.1198/sbr.2009.0021
  • Hothorn LA (2005) Biostatistics in nonclinical and preclinical drug developmentBiometrical Journal 47(3)282-285
    DOI: 10.1002/bimj.200510128
  • Dilba G, Bretz F, Guiard V, Hothorn LA (2004) Simultaneous confidence intervals for ratios with application to the comparison of several treatments with a controlMethods of Information in Medicine 43(5)465-469
    DOI: 10.1267/METH04050465
  • Hothorn LA, Bauss F (2004) Biostatistical design and analyses of long-term animal studies simulating human postmenopausal osteoporosisDrug Information Journal 38(1)47-56
    DOI: 10.1177/009286150403800107
  • Neuhäuser M, Buening H, Hothorn LA (2004) Maximum test versus adaptive tests for the two-sample location problemJournal of Applied Statistics 31(2):215-227
    DOI: 10.1080/0266476032000148876
  • Biesheuvel E, Hothorn LA (2003) Protocol designed subgroup analyses in multiarmed clinical trials: multiplicity aspectsJournal of Biopharmaceutical Statistics 13(4)663-673
    DOI: 10.1081/BIP-120024201
  • Bretz F, Hothorn LA (2003) Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assaysATLA: Alternatives to Lab Animals 31(1):81-96
  • Bretz F, Hothorn LA, Hsu J (2003) Identifying effective and/or safe doses by stepwise confidence intervals for ratiosStatistics in Medicine 22(6)847-858
    DOI: 10.1002/sim.1449
  • Hauschke D, Hothorn LA (2003) Two-stage testing of safety: A statistical viewATLA: Alternatives to Lab Animals 31(1):77-80
  • Hirotsu C, Hothorn LA (2003) Impact of the ICH E9 guideline: statistical principles for clinical trials on the conduct of clinical trials in JapanDrug Information Journal 37(4)381-396
    DOI: 10.1177/009286150303700405
  • Hothorn LA (2003) Statistics of interlaboratory in vitro toxicological studiesATLA: Alternatives to Lab Animals 31(1):43-63
  • Hothorn LA, Bretz F (2003) Dose-response and thresholds in mutagenicity studies: A statistical testing approachATLA: Alternatives to Lab Animals 31(1):97-103
  • Hothorn LA, Wassmer G (2003) Analyzing randomized dose finding studies with a primary and a secondary endpointJournal of Biopharmaceutical Statistics 13(2)301-305
    DOI: 10.1081/BIP-120019273
  • Neuhäuser M, Leisler B, Hothorn LA (2003) A trend test for the analysis of multiple paternityJournal of Agricultural, Biological, and Environmental Statistics 8:29-35
    DOI: 10.1198/1085711031184
  • Bauss F, Lalla S, Endele R, Hothorn LA (2002) Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged ratsJournal of Rheumatology 29(10):2200-2208
  • Bauss F, Wagner M, Hothorn LA (2002) Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged ratsJournal of Rheumatology 29(5)990-998
  • Biesheuvel E, Hothorn LA (2002) Many-to-one comparisons in stratified designsBiometrical Journal 44(1)101-116
    DOI: 10.1002/1521-4036(200201)44:13.0.CO;2-H
  • Bretz F, Hothorn LA (2002) Detecting dose–response using contrasts: asymptotic power and sample size determination for binomial dataStatistics in Medicine 21(2)3325-3335
    DOI: 10.1002/sim.1324
  • Hothorn LA (2002) Selected biostatistical aspects of the validation of in vitro toxicological assaysATLA: Alternatives to Lab Animals 30(2):93-98
  • Schulte A, Althoff J, Ewe S, Richter-Reichhelm HB; BGVV Group Investigators (2002) Two immunotoxicity ring studies according to OECD TG 407-comparison of data on cyclosporin A and hexachlorobenzeneRegulatory Toxicology and Pharmacology 36(1):12-21
    DOI: 10.1006/rtph.2002.1568
  • Weichert M, Hothorn LA (2002) Robust hybrid tests for the two-sample location problemCommunications in Statistics - Simulation and Computation 31:175-187
    DOI: 10.1081/SAC-120003333
  • Bauer P, Hothorn LA, Westfall P (2001) Special issue multiple comparison proceduresBiometrical Journal 43:531
  • Bretz F, Genz A, Hothorn LA (2001) On the numerical availibilty of multiple comparison proceduresBiometrical Journal 43(5)645-656
    DOI: 10.1002/1521-4036(200109)43:5<645::AID-BIMJ645>3.0.CO;2-F
  • Bretz F, Hothorn LA (2001) Testing dose-response relationships with a priori unknown possibly nonmonotone shapesJournal of Biopharmaceutical Statistics 11(3)193-207
    DOI: 10.1081/BIP-100107657
  • Munzel U, Hothorn LA (2001) An unified approach to simultaneous rank test procedures in the unbalanced one-way layoutBiometrical Journal 43(5)553-559
    DOI: 10.1002/1521-4036(200109)43:5<553::AID-BIMJ553>3.0.CO;2-N
  • Tamhane AC, Hothorn LA (2001) Letter to the editor: A multiple comparison procedure for the three and four-armed controlled clinical trialsStatistics in Medicine 20(2)317-321
  • Bretz F, Hothorn LA (2000) A powerful alternative to Williams' test with application to toxicological doseresponse relationships of normally distributed dataEnvironmental and Ecological Statistics 7:135-154
    DOI: 10.1023/A:1009622928188
  • Hothorn LA, Bretz F (2000) One-sided simultaneous confidence intervals for effective dose steps in unbalanced designsBiometrical Journal 42:995-1006
    DOI: 10.1002/1521-4036(200012)42:8<995::AID-BIMJ995>3.0.CO;2-4
  • Hothorn LA, Bretz F (2000) Evaluation of animal carcinogenicity studies. Cochran-Armitage trend test vs. multiple contrast testsBiometrical Journal 42(5)553-567
    DOI: 10.1002/1521-4036(200009)42:5<553::AID-BIMJ553>3.0.CO;2-R
  • Hothorn LA, Hauschke D (2000) Identifying the maximum safe dose: a multiple testing approachJournal of Biopharmaceutical Statistics 10(1)15-30
    DOI: 10.1081/BIP-100101010
  • Hothorn LA, Hayashi M, Seidel D (2000) Dose-response relationships in mutagenicity assays including an appropriate positive control group: a multiple testing approachEnvironmental and Ecological Statistics 7:27-42
    DOI: 10.1023/A:1009654728475
  • Lehmacher W, Kieser M, Hothorn LA (2000) Sequential and multiple testing for dose-response analysisDrug Information Journal 34(2)591-597
    DOI: 10.1177/009286150003400227
  • Neuhäuser M, Hothorn LA (2000) Parametric location-scale and scale trend tests based on Levene’s transformationComputational Statistics and Data Analysis 33:189-200
    DOI: 10.1016/S0167-9473(99)00051-1
  • Neuhäuser M, Seidel D, Hothorn LA (2000) Robust trend tests with application to toxicologyEnvironmental and Ecological Statistics 7:43-56
    DOI: 10.1023/A:1009606812545
  • Hauschke D, Kieser M, Hothorn LA (1999) Proof of safety in toxicology based on the ratio of two means for normally distributed dataBiometrical Journal 41(3)295-304
    DOI: 10.1002/(SICI)1521-4036(199906)41:3<295::AID-BIMJ295>3.0.CO;2-2
  • Hothorn LA (1999) Trend tests in epidemiology: p-values or confidence intervals?Biometrical Journal 41(7)817-825
    DOI: 10.1002/(SICI)1521-4036(199911)41:73.0.CO;2-C
  • Koch H-F, Hothorn LA (1999) Exact unconditional distributions for dichotomous data in many-to-one comparisonsJournal of Statistical Planning and Inference 82(1-2):83-99
    DOI: 10.1016/S0378-3758(99)00033-6
  • Neuhäuser M, Hothorn LA (1999) An exact Cochran-Armitage test for trend when dose-response shapes are a priori unknownComputational Statistics and Data Analysis 30(4)403-412
    DOI: 10.1016/S0167-9473(98)00091-7
  • Bauer P, Röhmel J, Maurer W, Hothorn LA (1998) Testing strategies in multi-dose experiments including active controlStatistics in Medicine 17(18):2133-2146
    DOI: 10.1002/(SICI)1097-0258(19980930)17:18<2133::AID-SIM901>3.0.CO;2-2
  • Bolte R, Walz M, Lehmann KJ, Hothorn T, Brill C, Hothorn LA, Georgi M (1998) Teleradiology: results of a questionnaire of German radiologistsJournal of Telemedicine and Telecare 4 Suppl 1:69-71
    DOI: 10.1258/1357633981931524
  • Fairweather WR, Bhattacharyya A, Ceuppens PP, Heimann G, Hothorn LA, Kodell RL, Lin KK, Mager H, Middleton BJ, Slob W, Soper KA, Stallard N, Ventre J, Wright J (1998) Biostatistical Methodology in Carcinogenicity StudiesDrug Information Journal 32:401-421
    DOI: 10.1177/009286159803200212
  • Lalla S, Hothorn LA, Haag N, Bader R, Bauss F (1998) Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in ratsOsteoporosis International 8(2):97-103
    DOI: 10.1007/BF02672503
  • Neuhäuser M, Hothorn LA (1998) An analogue of Jonckheere’s trend test for parametric and dichotomous dataBiometrical Journal 40(1)11-19
    DOI: 10.1002/(SICI)1521-4036(199804)40:1<11::AID-BIMJ11>3.0.CO;2-0
  • Neuhäuser M, Liu P-Y, Hothorn LA (1998) Nonparametric tests for trend: Jonckheere’s test, a modification and a maximum testBiometrical Journal 40:899-909
    DOI: 10.1002/(SICI)1521-4036(199812)40:8<899::AID-BIMJ899>3.0.CO;2-9
  • Hothorn LA (1997) Modifications of the closure principle for analyzing toxicological studiesDrug Information Journal 31(2)403-412
    DOI: 10.1177/009286159703100211
  • Hothorn LA, Lin KK, Hamada C, Rebel W (1997) Recommendations for Biostatistics of Repeated Toxicity StudiesDrug Information Journal 30(2):327-334
    DOI: 10.1177/009286159703100203
  • Hothorn LA, Martin U (1997) Application of adaptive interim analysis in pharmacologyDrug Information Journal 31(2):615-619
    DOI: 10.1177/009286159703100229
  • Hothorn LA, Neuhäuser M, Koch H-F (1997) Analysis of randomized dose-finding studies: closure test modifications based on multiple contrast testsBiometrical Journal 39(4)467-479
    DOI: 10.1002/bimj.4710390408
  • Kropf S, Hothorn LA, Läuter J (1997) Multivariate many-to-one procedures with applications to pre-clinical trialsDrug Information Journal 31(2):433-447
    DOI: 10.1177/009286159703100214
  • Neuhäuser M, Hothorn LA (1997) The control of consumer’s risk in the Ames mutagenicity assayDrug Information Journal 31(2):363-367
    DOI: 10.1177/009286159703100207
  • Neuhäuser M, Hothorn LA (1997) Trend tests for dichotomous endpoints with application in carcinogenicity studiesDrug Information Journal 31(2):463-469
    DOI: 10.1177/009286159703100217
  • Hauschke D, Steinjans VW, Hothorn LA (1996) A note on Welch’s approximate t-solution to bioequivalence assessmentBiometrika 83:236-237
    DOI: 10.1093/biomet/83.1.236
  • Hothorn LA (1994) Multiple Comparisons in Long-Term Toxicity StudiesEnvironmental Health Perspectives 102 Suppl 1:33-38
    DOI: 10.1289/ehp.94102s133
  • Hothorn LA (1994) Biostatistical analysis of the micronucleus mutagenicity assay based on the assumption of a mixing distributionEnvironmental Health Perspectives 102 Suppl 1:121-125
    DOI: 10.1289/ehp.94102s1121
  • Hothorn LA, Hajian G (1994) Biostatistical Aspects of ToxicokineticsDrug Information Journal 28:187-190
    DOI: 10.1177/009286159402800123
  • Hothorn LA, Lehmacher W (1991) A simple testing procedure 'control versus k treatments' for one-sided ordered alternativesBiometrical Journal 33(2)179-189
    DOI: 10.1002/bimj.4710330208
  • Kälble T, Tricker AR, Berger M, Amelung F, Waldherr R, Hothorn L, Möhring K, Staehler G (1991) Tumor induction in a rat model for ureterosigmoidostomy without evidence of nitrosamine formationJournal of Urology 146(3)862-866
    DOI: 10.1016/S0022-5347(17)37949-1
  • Solecki R, Hothorn LA, Holzweissig M, Heinrich V (1991) Computerised analysis of pathological findings in longterm trials with Phenylmeruric acetate in ratsArchives of Toxicology Supplement 14:100-103
    DOI: 10.1007/978-3-642-74936-0_21
  • Hothorn LA (1989) A simple statistical procedure for testing tumour rates in animal carcinogenicity experimentsArchives of Toxicology Supplement 13:265-268
    DOI: 10.1007/978-3-642-74117-3_47
  • Hothorn LA (1989) Robustness study on Williams and Shirley procedure, with application in toxicologyBiometrical Journal 31(8)891-903
    DOI: 10.1002/bimj.4710310802
  • Hothorn LA (1989) On the behaviour of Fligner/Wolfe trend test 'control versus k treatments', with application in toxicologyBiometrical Journal 31(7)767-780
    DOI: 10.1002/bimj.4710310702


  • Hothorn LA (2015) Statistics in Toxicology Using RChapman and Hall/CRC
    ISBN: 9781498701273 CAT# K24557
  • Hothorn LA (ed.) (1991) Modern Statistical Methods in ToxicologyLecture Notes in Medical Informatics, Vol. 41, Springer
  • Hothorn LA (1990) Probleme der Toxikologie Vol. 5Verlag Volk und Gesundheit, Berlin


  • Reichl FX, Schwenk M (ed) (2014) Regulatory Toxicology. Chapter: Statistical Evaluation Methods in ToxicologySpringer Heidelberg 213-223
    DOI: 10.1007/978-3-642-35374-1_44
  • Marquardt H, Schäfer SG, Barth H (Hrsg.) (2013) Lehrbuch der ToxikologieWissenschaftliche Verlagsgesellschaft Stuttgart, vollständig überarbeitete und erweiterte Auflage ISBN 978-3-8047-2876-9 darin: Biometrie
  • Lin D, Djira GD, Shkedy Z, Burzykowski T, Hothorn LA (2012) Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts TestModeling Dose-Response Microarray Data in Early Drug Development Experiments Using R Use R!, 2012, Part 2, 249-258
  • Lin D, Hothorn LA, Djira GD, Bretz F (2012) Multiple Contrasts Test for Testing Dose-Response under Order-Restricted AlternativesModeling Dose-Response Microarray Data in Early Drug Development Experiments Using R; Use R! 233-247
    DOI: 10.1007/978-3-642-24007-2_15
  • Lin D, Yekutieli D, Djira GD, Hothorn LA (2012) Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement RateModeling Dose-Response Microarray Data in Early Drug Development Experiments Using R; Use R! 259-267
    DOI: 10.1007/978-3-642-24007-2_16
  • Marquardt H, Schäfer SG (2003) Lehrbuch Toxikologie. Darin: BiostatistikWissenschaftliche Verlagsgesellschaft
  • Bretz F, Hothorn LA (2001) Multiple comparisons in repeated measures designs, with biomedical applications. In: Mathematical Statistics with Applications in BiometryFestschrift in honour of S. Schach, eds. J. Kunert, G. Trenkler. J. Eul. Verlag Lohmar 303-312
  • Hauschke D, Hothorn LA (1998) Safety assessment in toxicology studies: proof of safety versus proof of hazardChow S-C, Liu J-P (eds.): Design and analysis of animal studies in pharmaceutical development. Chapter 6. Marcel Dekker, New York, 197-226
  • Hothorn LA, Hauschke D (1998) Statistical Testing Principles in Randomized Toxicological StudiesChow S-C, Liu J-P (eds.): Design and analysis of animal studies in pharmaceutical development. Chapter 4. Marcel Dekker, New York, 79-134
  • Rasch D et al. (eds.) (1998) Verfahrensbibliothek Versuchsplanung und –auswertung Band II. Mitarbeit an mehreren Verfahren (Hothorn LA)R. Oldenburg Verlag München
  • Hothorn LA (1997) New statistical methods for analyzing mutagenicity assays: real data problems in biopharmeceutical drug developmentKitsos, C.P.; Edler, L. (eds.): Industrial statistics. Physica Verlag Heidelberg, 201-208
  • Hothorn LA, Hauschke D, Senn SJ, Lehmacher W (1997) Pro’s and con’s of cross-over trialsVollmar, J; Hothorn LA (Eds.) Cross-over clinical trials. Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 97
  • Hothorn LA, Hauschke D, Senn SJ, Lehmacher W (1997) Cross-over trials: references of the last six yearsVollmar, J; Hothorn LA (Eds.) Cross-over clinical trials. Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 73-96
  • Neuhäuser M, Hothorn LA (1997) Adaptive tests for trendKitsos CP, Edler L (eds.): Industrial statistics. Physica Verlag Heidelberg, 269-273.
  • Vollmar J, Hothorn LA (Eds.) (1997) Cross-over clinical trialsBiometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 1-97
  • Hajian G, Hothorn LA (1995) Biostatistical aspects of concomitant toxicokineticsVollmar J (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6, Fischer Verlag Stuttgart, 115-133
  • Hothorn LA (1995) Biostatistical analysis of the experimental design ‘control versus k treatments’ including a positive control groupVollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6; Fischer Verlag Stuttgart, 19-26
  • Maurer W, Hothorn LA, Lehmacher W (1995) Multiple comparisons in drug clinical trials and preclinical assays: a-priori ordered hypothesesVollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6; Fischer Verlag Stuttgart, 3-18
  • Ortseifen C, Hothorn LA (1995) Multiple Vergleiche ‘Kontrolle gegen k Behandlungen’ bei Abweichung von den ANOVA-AnnahmenVollmar J (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6, Fischer Verlag Stuttgart, 77-100
  • Marquardt H, Schäfer SG (1994) Lehrbuch der Toxikologie. Darin: BiometrieWissenschaftsverlag Mannheim 15-31
  • Hothorn LA (1992) Sample size estimation for several trend tests in the k-sample problemComputational Statistics. (Ed.: Dodge,Y. and Whittaker,J.), Physica-Verlag Heidelberg, Vol. 2; 387-390
  • Hothorn LA, Nagel M (1992) Eine Software-Umgebung zur kombinierten exploratorischen und konfirmatorischen Datenanalyse bei multivariaten Fragestellungen in präklinischen und klinischen StudienMethoden und Werkzeuge für die exploratorische Datenanalyse in den Biowissenschaften. G. Fischer, Stuttgart
  • Nagel M, Hothorn LA, Hartmann P (1992) Hochinteraktive Datenanalyse- Werkzeuge und PrinzipienMethoden und Werkzeuge für die exploratorische Datenanalyse in den Biowissenschaften. G. Fischer, Stuttgart


  • Menke S, Poehling HM, Gerhard D (2011) Application of generalized linear model based multiple comparison procedures to greenhouse pest control experimentsActa Horticulturae 893:1233-1238
  • Gerhard D, Schaarschmidt F (2007) Proof of safety for non-target species: a confidence interval approach. Proceedings of the International Symposium Agricultural Field Trials – Today and TomorrowStuttgart-Hohenheim: 37-43


  • Fneish F (2018) Treatment comparisons of count data with only 0s in one treatment group, M.Sc. thesis
  • Vogel KC (2018) Simultaneous Inference for the Comparison of Overdispersed Multinomial Data, Ph.D. thesis
  • Domes HS (2016) Validity of Confidence Intervals in Case of Model Selection Uncertainty, M.Sc. Thesis | Datei |
  • Pallmann P (2016) Multiple Contrast Tests with Repeated and Multiple Endpoints|with Biological ApplicationsPh.D. Thesis | Datei |
  • Schaarschmidt F (2016) Simultane Konfidenzintervalle für multiple Vergleiche - Ansätze für nicht Gauß-verteilte Daten und Inferenz in linearen Modellen, Habil | Datei |
  • Kitsche A (2014) Evaluation of interaction effects in two-factorial designs by simultaneous confidence intervals in the cell means modelPh.D. Thesis | Datei |
  • Gerhard D (2010) Simultaneous small sample inference based on profile likelihoodPh.D. Thesis | Datei |
  • Scherer R (2010) Simultaneous Confidence Intervals for Biodiversity Indices with Application to Overdispersed Multinomial Count DataM.Sc. Thesis | Datei |
  • Schmidt M (2010) Multiple comparisons of populations based on genetic marker dataM.Sc. Thesis | Datei |
  • Hasler M (2009) Extensions of Multiple Contrast TestsPh.D. Thesis | Datei |
  • Mi X (2009) Model Selection Procedure with Familywise Error Rate Control for Binomial Order-Restricted ProblemsPh.D. Thesis | Datei |
  • Schaarschmidt F (2009) Marginal and simultaneous confidence intervals for abundance data with applications to safety assessment of non-target speciesPh.D. Thesis | Datei |
  • Menke S (2008) Einfluss von Neem Azal-U und Neem-Pellet auf Trialeurodes vaporariorum und Encarsia formosa unter besonderer Berücksichtigung der biostatistischen Bewertung der Versuchsdaten mittels Generalisierter Linearer ModelleM.Sc Thesis | Datei |
  • Frömke C (2006) Relevance-shifted tests for high dimensional data with small sample sizesPh.D. Thesis | Datei |
  • Gerhard D (2006) Poisson confidence intervals for testing the equality of abundance data in generalized linear modelsDiplomarbeit | Datei |
  • Dilba G (2005) Simultaneous Inference for Ratios of Location ParametersPh.D. Thesis | Datei |
  • Schaarschmidt F (2005) Binomial group testing – Design and AnalysisDiplomarbeit | Datei |
  • Ma D (2004) Small Sample Inference For The Two-Sample DesignM.Sc. Thesis | Datei |
  • Bretz F (2003) Planung und Auswertung von Dosis-Wirkungs-Studien unter Verwendung von multiplen TestprozedurenPh.D. Thesis | Datei |
  • Biesheuvel E (2002) Many-to-one comparisons in stratified designsPh.D. Thesis | Datei |
  • Frömke C (2001) Simultaneous tests and confidence intervals for experimental agricultural designsDiplomarbeit | Datei |
  • Seidel D (2000) Trendtests für geordnete kategoriale Daten bei sehr kleinen FallzahlenPh.D. Thesis | Datei |
  • Bretz F (1999) Powerful Modifications of Williams' Test on TrendPh.D. Thesis | Datei |
  • Hauschke D (1999) Biometrische Methoden zur Planung und Auswertung von SicherheitsstudienPh.D. Thesis | Datei |


  • Schaarschmidt F, Hothorn LA (2014) Simple prediction intervals for one future observation for simple, balanced random effects models | Datei |
  • Hasler M (2010) Multiple contrast tests for multiple endpoints | Datei |
  • Hasler M (2008) Equivalence for multiple endpoints | Datei |
  • Hasler M (2008) Robustness simulation study for continuous endpoints in one-way-layouts | Datei |
  • Hasler M (2008) Equivalence with respect to a control | Datei |
  • Schaarschmidt F (2008) Properties of confidence intervals for the comparison of small binomial proportions when sample sizes are large | Datei |
  • Gerhard D (2007) CI for Odds Ratios accounting for Extra Variation between Replicated Experiments | Datei |
  • Hasler M (2007) IUT for multiple endpoints | Datei |
  • Schaarschmidt F (2007) Confidence intervals for the proof of safety for abundance data | Datei |
  • Schaarschmidt F (2007) Confidence intervals and limits for the risk ratio revisited | Datei |
  • Schaarschmidt F (2007) Confidence intervals for the ratio of means of two normal distributed populations in the presence of heteroscedasticity | Datei |
  • Sill M (2007) Approximate one-sided two-sample confidence limits for the comparison of a treatment versus a near-zero spontaneous rate in control | Datei |
  • Sill M, Schaarschmidt F (2007) Approximate simultaneous confidence intervals for the evaluation of long term carcinogenicity trials | Datei |
  • Sill M, Schaarschmidt F (2007) Approximate simultaneous confidence intervals and tests for proportions using multiple Williams contrasts | Datei |