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Publikationen // Beiträge // Poster

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GESAMTLISTE PUBLIKATIONEN

Rezensierte Zeitschriften

  • Menssen M, Linde M, Otunga Omondi E, Abukutsa-Onyango M, Dinssa FF, Winkelmann T (2017) Genetic and morphological diversity of cowpea (Vigna unguiculata (L.) Walp.) entries from East Africa, Scientia Horticulturae 226: 268–276
    DOI: 10.1016/j.scienta.2017.08.003
  • Otava M, Sengupta R, Shkedy Z (2017) IsoGeneGUI: Multiple Approaches for Dose-Response Analysis of Microarray Data Using R, R JOURNAL Volume: 9 Issue: 1 Pages: 14-26
  • Otava M, Shkedy Z, Hothorn LA, Talloen W, Gerhard D, Kasim A (2017) Identification of the Minimum Effective Dose for Normally Distributed Data Using a Bayesian Variable Selection Approach, Journal of Biopharmaceutical Statistics
    DOI: www.tandfonline.com/doi/full/10.1080/10543406.2017.1295247
  • Große Ruse M, Ritz C, Hothorn LA (2016) Simultaneous inference of a binary composite endpoint and its components, Journal of Biopharmaceutical Statistics
    DOI: 10.1080/10543406.2016.1148704
  • Hothorn LA (2016) The two-step approach - a significant ANOVA F-test before Dunnett's comparisons against a control - is not recommended, Communications in Statistics - Simulation and Computation
  • Kitsche A, Ritz C, Hothorn LA (2016) A General Framework for the Evaluation of Genetic Association Studies Using Multiple Marginal Models, Hum Hered 81:150-172
    DOI: 10.1159/000448477
  • Pallmann P, Hothorn LA (2016) Analysis of means (ANOM): a generalized approach using R, Journal of Applied Statistics
    DOI: 10.1080/02664763.2015.1117584
  • Santiago J, Brandt B, Wildhagen M, Hohmann U, Hothorn LA, Butenko MA, Hothorn M (2016) Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission, eLife
    DOI: http://dx.doi.org/10.7554/eLife.15075
  • Baeßler, B., Schaarschmidt, F., Dick, A., Stehning, C., Schnackenburg, B., Michels, G., Maintz, D., Bunck, A.C. (2015) Mapping tissue inhomogeneity in acute myocarditis: a novel analytical approach to quantitative myocardial edema imaging by T2-mapping, Journal of Cardiovascular Magnetic Resonance. 17:115
    DOI: 10.1186/s12968-015-0217-y
  • Baeßler, B., Schaarschmidt, F., Schnackenburg, B., Stehning, C., Giolda, A., Maintz, D, Bunck, A.C. (2015) Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experiences, Journal of Cardiovascular Magnetic Resonance. 17:67
    DOI: 10.1186/s12968-015-0177-2
  • Bredemeier, B., von Haaren, C., Rüter, S., Schaarschmidt, F., Reich, M. (2015) Spatial congruence between organic farming and biodiversity related landscape features in Germany, International Journal of Biodiversity Science, Ecosystem Services & Management 11(4) 330-340
    DOI: 10.1080/21513732.2015.1094515
  • Karanja J, Poehling HM, Pallmann P (2015) Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter in the control of whiteflies Aleyrodes proletella and Trialeurodes vaporariorum, accepted for publication in Journal of Economic Entomology
  • Kitsche A, Schaarschmidt F (2015) Analysis of Statistical Interactions in Factorial Experiments, Journal of Agronomy and Crop Science 201(1): 69-79.
    DOI: 10.1111/jac.12076
  • Konietschke F, Placzek M, Schaarschmidt F, Hothorn LA (2015) nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals, Journal of Statistical Software 46, 9
  • Matthies, S., Rüter, S., Prasse, R., Schaarschmidt, F. (2015) Factors driving the vascular plant species richness in urban green spaces: Using a multivariable approach, Landscape and Urban Planning
    DOI: 10.1016/j.landurbplan.2014.10.014
  • Pallmann P, Hothorn LA (2015) Boxplots for grouped and clustered data in toxicology, Arch Tox
    DOI: 10.1007/s00204-015-1608-4
  • Radespiel, U., Schaber, K., Kessler, S.E., Schaarschmidt, F., Strube, C. (2015) Variations in the excretion patterns of helminth eggs in two sympatric mouse lemur species (Microcebus murinus and M. ravelobensis) in northwestern Madagascar, Parasitology Research 114 (3): 941-954.
    DOI: 10.1007/s00436-014-4259-0
  • Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA (2015) Statistical approaches for the determination of cut points in anti-drug antibody bioassays, Journal of Immunological Methods 418, 84–100
    DOI: 10.1016/j.jim.2015.02.004
  • Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA (2015) Statistical approaches for the determination of cut points in anti-drug antibody bioassays, Journal of Immunological Methods
    DOI: 10.1186/s12968-015-0177-2
  • Weese A, Pallmann P, Papenbrock J, Riemenschneider A (2015) Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack, Frontiers in Plant Science, 6:9
  • Kitsche A (2014) Detecting qualitative interactions in clinical trials with binary responses, Pharmaceutical Statistics 13(5): 309-315 , doi: 10.1002/pst.1632
  • Bohne H, Wanjiku J, Rathke A-K, Humpert S, Gerhard D (2014) Influence of Nutrient Loading on Growth, N-, P-, and K-Concentrations and Outplanting Performance of Rosa majalis, European Journal of Horticultural Science 79(1):29-35
  • Gerhard D (2014) Simultaneous Small Sample Inference For Linear Combinations Of Generalized Linear Model Parameters, Communications in Statistics - Simulation and Computation. Accepted Author Version, DOI:10.1080/03610918.2014.895836
  • Gerhard D, Bremer M, Ritz C (2014) Estimating marginal properties of quantitative real-time PCR data using nonlinear mixed models., Biometrics 70(1):247-254, DOI: 10.1111/biom.12124
  • Graf N, Dinkel B, Rose H, Hothorn LA, Gerhard D, Johansen P, Kundig TM, Klimek L, Senti G (2014) A critical appraisal of analyzing nasal provocation test results in allergen immunotherapy trials., Rhinology 52(2):137-141, DOI: 10.4193/Rhin
  • Hothorn LA (2014) Statistical evaluation of toxicological bioassays –a review, Toxicology Research 3:418-432 DOI: 10.1039/c4tx00047a
  • Jaki Th, Kitsche A, Hothorn LA (2014) Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group, JP Journal of Biostatistics 11(1):1-32
  • Kitsche A, Hothorn LA (2014) Testing for qualitative interaction using ratios of treatment differences, Statistics in Medicine 33(9):1477-1489 doi: 10.1002/sim.6048
  • Kuiper RM, Gerhard D, Hothorn LA (2014) Identification of the Minimum Effective Dose for Normally Distributed Endpoints Using a Model Selection Approach, Statistics in Biopharmaceutical Research 6(1):55-66, DOI:10.1080/19466315.2013.847384
  • Pallmann P (2014) Book review: Applied meta-analysis with R, Journal of Applied Statistics 42(4): 914-915
  • Pallmann P, Hothorn LA, Djira GD (2014) A Levene-type test of homogeneity of several variances against ordered alternatives, Computational Statistics 29(6): 1593-1608
  • Schaarschmidt F and Hothorn LA (2014) Statistical Methods and Software for Validation Studies on New In Vitro Toxicity Assays, ATLA: Alternatives to Lab Animals 42:319-329
  • Hasler M, Hothorn LA (2013) Simultaneous confidence intervals on multivariate non-inferiority, Statistics in Medicine, 32(10) 1720-1729, DOI: 10.1002/sim.5633
  • Herberich E, Hothorn LA (2013) A Maximum-Type Association Test for Censored Time-to-Event Data, Journal of Biometrics & Biostatistics, 4: 178. doi: 10.4172/2155-6180.1000178
  • Hothorn LA, Reisinger K, Wolf T, Poth A, Fieblinger D, Liebsch M, Pirow R (2013) Statistical analysis of the hens egg test for micronucleus induction (HET-MN Assay), Mutation Research, 757:68-78
  • Jaki T, Hothorn LA (2013) Statistical evaluation of toxicological assays: Dunnett or Williams test- take both, Archives of Toxicology, 87:1901-1910
  • Jaki T, Pallmann P, Wolfsegger MJ (2013) Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs, Statistics in Medicine 32(30): 5469-5483
  • Jaki T, Pallmann P, Wolfsegger MJ (2013) Authors' reply to Comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs", Statistics in Medicine 32(30): 5487-5488
  • Kitsche A, Kalesse M (2013) Configurational Assignment of Secondary Hydroxyl Groups and Methyl Branches in Polyketide Natural Products through Bioinformatic Analysis of the Ketoreductase Domain, ChemBioChem 14(7):851-61. doi: 10.1002/cbic.201300063
  • Konietschke F (2013) Nparcomp-, Journal of Statistical Software, accepted
  • Konietschke F, Bösiger S, Brunner E, Hothorn LA (2013) Are Multiple Contrasts Tests superior to the ANOVA?, International Journal of Biostatistics, DOI 10.1515/ijb-2012-0020
  • Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn LA, Bremer S, van Thriel C, Krause K-H, Hengstler JG, Rahnenführer J (2013) Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach, Archives of Toxicology 87(1):123-143, DOI 10.1007/s00204-012-0967-3
  • Loley C, König I, Hothorn LA, Ziegler A (2013) A unifying framework for robust association testing,estimation, and genetic model selection using the generalized linear model, European Journal of Human Genetics 21, 12; 1442-1448 DOI: 10.1038/ejhg.2013.62
  • Maurer W and Bretz F (2013) Memory and other properties of multiple test procedures generated by entangled graphs, Statistics in Medicine (in press)
  • Priesnitz, K.-U., Benker, U., Schaarschmidt, F. (2013) Assessment of the potential impact of a Bt maize hybrid expressing Cry3Bb1 on ground beetles (Carabidae), Journal of Plant Diseases and Protection 120 (3), 131–140.
  • Ritz C, Gerhard D, Hothorn LA (2013) A unified framework for benchmark dose estimation applied to mixed models and model averaging, Statistics in Biopharmaceutical Research 5(1):79-90, DOI:10.1080/19466315.2012.757559
  • Schaarschmidt, F. (2013) Simultaneous confidence intervals for multiple comparisons among expected values of log-normal variables, Computational Statistics and Data Analysis 58, 265–275.
    DOI: 10.1016/j.csda.2012.08.011
  • Scherer, R., Schaarschmidt, F., Prescher, S., Priesnitz, K.U. (2013) Simultaneous confidence intervals for comparing biodiversity indices estimated from overdispersed count data, Biometrical Journal 55 (2), 246–263
    DOI: 10.1002/bimj.201200157
  • Schlingmann, B., Schadzek, P., Hemmerling, F., Schaarschmidt, F., Heisterkamp, A., Ngezahayo, A. (2013) The role of the C-terminus in functional expression and internalization of rat connexin46 (rCx46), Journal of Bioenergetics and Biomembranes, 45, 59–70.
    DOI: 10.1007/s10863-012-9480-x
  • Bohne H, Kluge K, Amha Y, Gerhard D (2012) Influence of peats of different origins and decomposition degree on germination and early growth of Chinese cabbage, European Journal of Horticultural Science 77(5):211-218
  • Hasler M and Hothorn LA (2012) Simultaneous confidence intervals on multivariate non-inferiority, Statistics in Medicine (Epub ahead of print)
  • Hasler M and Hothorn LA (2012) A multivariate Williams-type trend procedure, Statistics in Biopharmaceutical Research 4:57-65
  • Herberich E and Hothorn LA (2012) Statistical evaluation of mortality in long-term carcinogenicity bioassays using a Williams-type procedure, Regulatory Toxicology and Pharmacology 64(1):26-34
  • Hoffmann S, Hothorn LA, Edler L, Kleensang A, Suzuki M, Phrakonkham P, Gerhard D (2012) Two new approaches to improve the analysis of BALB/c 3T3 cell transformation assay data, Mutation Research - Genetic Toxicology and Environmental Mutagenesis 744(1):36-41
  • Hothorn LA, Libiger O, Gerhard D (2012) Model-specific tests on variance heterogeneity for detection of potentially interacting genetic loci, BMC Genetics 13:59
  • Kitsche A, Schaarschmidt F, Hothorn LA (2012) The use of historical controls in estimation of simultaneous confidence intervals for comparisons against a concurrent control, Computational Statistics and Data Analysis 56(12):3865-3875 doi:10.1016/j.csda.2012.05.010
  • Konietschke F and Hothorn LA (2012) Evaluation of toxicological studies using a non-parametric Shirley-type trend test for comparing several dose levels with a control group, Statistics in Biopharmaceutical Research 4:14-27
  • Konietschke F, Hothorn LA, Brunner E (2012) Rank-based multiple test procedures and simultaneous confidence intervals, Electronic Journal of Statistics 6:737-758
  • Konietschke F, Libiger O, Hothorn LA (2012) Nonparametric Evaluation of Quantitative Traits in Population-Based Association Studies when the Genetic Model is Unknown, PLoS ONE 7(2):e31242
  • Pallmann P, Schaarschmidt F, Hothorn LA, Fischer C, Nacke H, Priesnitz KU, Schork NJ (2012) Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indices, Molecular Ecology Resources 12(6): 1068-1078
  • Senti G, Crameri R, Kuster D, Johansen P, Martinez-Gomez JM, Graf N, Steiner M, Hothorn LA, Grönlund H, Tivig C, Zaleska A, Soyer O, van Hage M, Akdis CA, Akdis M, Rose H, Kündig TM (2012) Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections, Journal of Allergy and Clinical Immunology 129(5):1290-1296
  • Strohmaier J, Amelang M, Hothorn LA, Witt SH, Nieratschker V, Gerhard D, Meier S, Wüst S, Frank J, Loerbroks A, Rietschel M, Stürmer T, Schulze TG (2012) The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population, Molecular Psychatry 18(5):607-613, DOI:10.1038/mp.2012.53
  • Bohne H, Salomon L, Gerhard D (2011) Influence of provenance and fertilization in the tree nursery on outplanting performance and N-, P-, and K-content of Viburnum opulus L. in shoots and roots, Journal of Environmental Horticulture 29(3):137-142
  • Bunck AC, Kröger J-R, Juettner A, Brentrup A, Fiedler B, Schaarschmidt F, Crelier G, Schwindt W, Heindel W, Niederstadt T, Maintz D (2011) Magnetic resonance 4D flow characteristics of cerebrospinal fluid at the craniocervical junction and the cervical spinal canal, European Radiology 21, 1788–1796
  • Hasler M and Hothorn LA (2011) A Dunnett-Type Procedure for Multiple Endpoints, The International Journal of Biostatistics 7(1):1-15
  • Hirotsu C, Yamamoto S, Hothorn LA (2011) Estimating the Dose-Response Pattern by the Maximal Contrast Type Test Approach, Statistics in Biopharmaceutical Research 3:40-53
  • Hothorn LA and Djira GD (2011) A ratio-to-control Williams-type test for trend, Pharmaceutical Statistics 10(4):289-292
  • Selig M, Bohne H, Gerhard D (2011) Influence of refertilization of Salix cinerea L. in late summer on early frost hardiness and on some nutrients and biomarker, Gesunde Pflanzen 63(3):129-133
  • Bilder CR, Zhang B, Schaarschmidt F, Tebbs JM (2010) binGroup: A Package for Group Testing, The R Journal 2/2, 56-60
  • Djira GD, Schaarschmidt F, Fayissa B (2010) Inferences for Selected Location Quotients with Applications to Health Outcomes, Geographical Analysis 42:288-300
  • Gerhard D and Hothorn LA (2010) Rank transformation in Haseman-Elston regression using scores for location-scale alternatives, Human Heredity 69(3):143-151
  • Hothorn LA and Vohr HW (2010) Statistical Evaluation of the Local Lymph Node Assay, Regulatory Toxicology and Pharmacology 56(3):352-356
  • Hothorn LA, Sill M, Schaarschmidt F (2010) Evaluation of Incidence Rates in Pre-Clinical Studies Using a Williams-Type Procedure, The International Journal of Biostatistics 6(1): Article 15
  • Konietschke F, Bathke AC, Hothorn LA, Brunner E (2010) Testing and estimation of purely nonparametric effects in repeated measures designs, Computational Statistics and Data Analysis 54:1895-1905
  • Menke S and Gerhard D (2010) Detection of a related difference in efficacy of azadirachtin treatments for the control of whiteflies on Gerbera jamesonii by testing for interactions in generalised linear models, Pest Management Science 66(4):358-364
  • Rauschen S, Schaarschmidt F, Gathmann A (2010) Occurrence and field densities of Coleoptera in the maize herb layer: implications for Environmental Risk Assessment of genetically modified Bt-maize, Transgenic Research 19:727-744
  • Rauschen S, Schultheis E, Hunfeld H, Schaarschmidt F, Schuphan I, Eber S (2010) Diabrotica-resistant Bt-maize DKc5143 event MON88017 has no impact on the field densities of the leafhopper Zyginidia scutellaris, Environmental Biosafety Research 9, 87–99
  • Zimmermann H, Gerhard D, Dingermann T, Hothorn LA (2010) Statistical aspects of design and validation of microtitre-plate-based linear and non-linear parallel in vitro bioassays, Biotechnology Journal 5(1):62-74
  • Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010) An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 1, Pharmazeutische Industrie 72(4):708-712
  • Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010) An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 2, Pharmazeutische Industrie 72(5):884-895
  • Acutis M, Hothorn LA, McNicol J, van der Voet H (2009) Statistical considerations for the safety evaluation of GMOs, EFSA Journal 1250:1
  • Dette H, Trampisch M, Hothorn LA (2009) Robust Designs in Noninferiority Three-Arm Clinical Trials With Presence of Heteroscedasticity, Statistics in Biopharmaceutical Research 1(3):268-278
  • Djira GD and Hothorn LA (2009) Detecting Relative Changes in Multiple Comparisons with an Overall Mean, Journal of Quality Technology 41(1):60-65
  • Hothorn LA and Gerhard D (2009) Statistical evaluation of the in vivo micronucleus assay, Archives of Toxicology 83(6):625-634
  • Hothorn LA and Hothorn T (2009) Order-restricted Scores Test for the Evaluation of Population based Case–control Studies when the Genetic Model is Unknown, Biometrical Journal 51(4):1-11
  • Hothorn LA, Gerhard D, Hofmann M (2009) Parametric and non-parametric prediction intervals based phase II control charts for repeated bioassay data, Biologicals 37(5): 323-330
  • Hothorn LA, Vaeth M, Hothorn T (2009) Trend tests for the evaluation of exposure-response relationships in epidemiological exposure studies, Epidemiologic Perspectives & Innovations 6:1
  • Perry JN, ter Braak CJF, Dixon PM, Duan JJ, Hails RS, Huesken A, Lavielle M, Marvier M, Scardi M, Schmidt K, Tothmeresz B, Schaarschmidt F, van der Voet H (2009) Statistical aspects of environmental risk assessment of GM plants for effects on non-target organisms, Environmental Biosafety Research 8:65-78
  • Schaarschmidt F, Biesheuvel E, Hothorn LA (2009) Asymptotic Simultaneous Confidence Intervals for Many-to-One Comparisons of Binary Proportions in Randomized Clinical Trials, Journal of Biopharmaceutical Statistics 19:292-310
  • Schaarschmidt F, Vaas L (2009) Analysis of trials with complex treatment structure using multiple contrast tests, HortScience 44(1):188-195
  • Braat S, Gerhard D, Hothorn LA (2008) Joint one-sided and two-sided simultaneous confidence intervals, Journal of Biopharmaceutical Statistics. 18(2):293-306
  • Dilba G, Hothorn LA, Tsong Y (2008) Equivalence Tests for Shelf Life and Average Drug Content in Stability Studies, Journal of Biopharmaceutical Statistics 18:985-995
  • Froemke C, Hothorn LA, Kropf S (2008) Nonparametric relevance-shifted multiple testing procedures for the analysis of high-dimensional multivariate data with small sample sizes, BMC Bioinformatics 9:54
  • Hasler M and Hothorn LA (2008) Multiple Contrast Tests in the Presence of Heteroscedasticity, Biometrical Journal 50:793-800
  • Hasler M, Vonk R, Hothorn LA (2008) Assessing non-inferiority of a new treatment in a three-arm trial in the presence of heteroscedasticity, Statistics in Medicine 27:490-503
  • Hothorn LA and Hasler M (2008) Proof of hazard and proof of safety in toxicological studies using simultaneous confidence intervals for differences and ratios to control, Journal of Biopharmaceutical Statistics 18:915-933
  • Hughes S (2008) European regulatory agencies should employ full time statisticians, British Medical Journal 336(7638):250
  • Rauschen S, Eckert J, Schaarschmidt F, Schuphan I, Gathmann A (2008) An evaluation of methods for assessing the impacts of Bt-maize MON810 cultivation and pyrethroid insecticide use on Auchenorrhyncha (Planthoppers and Leafhoppers), Agricultural and Forest Entomology 10:331-339
  • Schaarschmidt F, Sill M, Hothorn LA (2008) Approximate Simultaneous Confidence Intervals for Multiple Contrasts of Binomial Proportions, Biometrical Journal 50:782-792
  • Schaarschmidt F, Sill M, Hothorn LA (2008) Poly-k-trend tests for survival adjusted analysis of tumor rates formulated as approximate multiple contrast test, Journal of Biopharmaceutical Statistics 18:934-948
  • Schunkert H, Götz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Linsel-Nitschke P, Cambien F, Hengstenberg C, Stark K, Blankenberg S, Tiret L, Ducimetiere P, Keniry A, Ghori MJ, Schreiber S, El Mokhtari NE, Hall AS, Dixon RJ, Goodall AH, Liptau H, Pollard H, Schwarz DF, Hothorn LA, Wichmann HE, König IR, Fischer M, Meisinger C, Ouwehand W, Deloukas P, Thompson JR, Erdmann J, Ziegler A, Samani NJ; Cardiogenics Consortium (2008) Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease, Circulation 117(13):1675-1684
  • Dilba G, Schaarschmidt F, Hothorn LA (2007) Inferences for ratios of normal means, R News 7(1):20-23
  • Hothorn LA (2007) How to deal with multiple treatment or dose groups in randomized clinical trials?, Fundamental & Clinical Pharmacology 21(2):137-154
  • Schaarschmidt F (2007) Experimental design for one-sided confidence intervals or hypothesis tests in binomial group testing, Communications in Biometry and Crop Science 2(1):32-40.
  • Toschki A, Hothorn LA, Ross-Nickoll M (2007) Effects of cultivation of genetically modified Bt maize on epigeic arthropods, Environmental Entomology 36(4):967-981
  • Dilba G, Bretz F, Hothorn LA, Guiard V (2006) Power and sample size computations in simultaneous tests for non-inferiority based on relative margins, Statistics in Medicine 25(7):1131-1147
  • Eckert J, Schuphan L, Hothorn LA, Gathmann A (2006) Arthropods on Maize Ears for Detecting Impacts of Bt Maize on Nontarget Organisms, Environmental Entomology 35:554-560
  • Gathmann A, Wirooks L, Hothorn LA, Bartsch D, Schuphan I. (2006) Impact of Bt maize pollen (MON810) on lepidopteran larvae living on accompanying weeds, Molecular Ecology 15(9):2677-2685
  • Hauschke D and Hothorn LA (2006) Letter to Editor: An introductory note to the CHMP guidelines: choice of the non-inferiority margin and data monitoring committees by David Brown, Peter Volkers and Simon Day, Statistics in Medicine 25:1623-1627; Statistics in Medicine 26:230-236
  • Hothorn LA (2006) Multiple comparisons and multiple contrasts in randomized dose-response trials - confidence interval orient approaches, Journal of Biopharmaceutical Statistics 16:711-731
  • Hothorn LA (2006) Statistical analysis of in vivo anticancer experiments: Tumor growth inhibition, Drug Information Journal 40:229-238
  • Hothorn LA and Bleiholder H (2006) Statistical effects of efficacy evaluation of plant protection products in field trials- a comment to EPPO standard PP1/152, EPPO Bulletin 36:31-45
  • Hothorn LA and Oberdörfer R (2006) Statistical analysis used in the nutritional assessment of novel food using the proof of safety, Regulatory Toxicology and Pharmacology 44:125-135
  • Neuhäuser M, Hothorn LA (2006) A robust modification of the ordered-heterogeneity test, Journal of Applied Statistics
  • Hothorn LA (2005) Biostatistics in nonclinical and preclinical drug development, Biometrical Journal 47:282-285
  • Dilba G, Bretz F, Guiard V, Hothorn LA (2004) Simultaneous confidence intervals for ratios with application to the comparison of several treatments with a control, Methods of Information in Medicine 43:465-469
  • Hothorn LA and Bauss F (2004) Biostatistical design and analyses of long-term animal studies simulating human postmenopausal osteoporosis, Drug Information Journal 38:47-56
  • Neuhäuser M, Buening H, Hothorn LA (2004) Maximum test versus adaptive tests for the two-sample location problem, Journal of Applied Statistics 31(2):215-227
  • Biesheuvel E and Hothorn LA (2003) Protocol designed subgroup analyses in multiarmed clinical trials: multiplicity aspects, Journal of Biopharmaceutical Statistics 13:663-673
  • Bretz F and Hothorn LA (2003) Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assays, ATLA: Alternatives to Lab Animals 31(1):81-96
  • Bretz F, Hothorn LA, Hsu J (2003) Identifying effective and/or safe doses by stepwise confidence intervals for ratios, Statistics in Medicine 22:847-858
  • Hauschke D and Hothorn LA (2003) Two-stage testing of safety: A statistical view, ATLA: Alternatives to Lab Animals 31(1):77-80
  • Hirotsu C and Hothorn LA (2003) Impact of the ICH E9 guideline: statistical principles for clinical trials on the conduct of clinical trials in Japan, Drug Information Journal 37:381-396
  • Hothorn LA (2003) Statistics of interlaboratory in vitro toxicological studies, ATLA: Alternatives to Lab Animals 31(1):43-63
  • Hothorn LA and Bretz F (2003) Dose-response and thresholds in mutagenicity studies: A statistical testing approach, ATLA: Alternatives to Lab Animals 31(1):97-103
  • Hothorn LA and Wassmer G (2003) Analyzing randomized dose finding studies with a primary and a secondary endpoint, Journal of Biopharmaceutical Statistics 13:301-305
  • Neuhäuser M, Leisler B, Hothorn LA (2003) A trend test for the analysis of multiple paternity, Journal of Agricultural, Biological, and Environmental Statistics 8:29-35
  • Bauss F, Lalla S, Endele R, Hothorn LA (2002) The effects of treatment with ibandronate on bone mass, architecture, biomechanical properties and bone concentration of ibandronate in ovariectomized aged rats, Journal of Rheumatology 29(10):2200-2208
  • Bauss F, Wagner M, Hothorn LA (2002) Total administered dose of Ibandronate determines its effect on bone mass, Journal of Rheumatology 29:990-998
  • Biesheuvel E and Hothorn LA (2002) Many-to-one comparisons in stratified designs, Biometrical Journal 44:101-116
  • Bretz F and Hothorn LA (2002) Detecting dose–response using contrasts: asymptotic power and sample size determination for binomial data, Statistics in Medicine 21:3325-3335
  • Hothorn LA (2002) Selected biostatistical aspects of the validation of in vitro toxicological assays, ATLA: Alternatives to Lab Animals 30(2):93-98
  • Schulte A, Althoff J, Ewe S, Richter-Reichhelm HB; BGVV Group Investigators (2002) Two immunotoxicity ring studies according to OECD TG 407-comparison of data on cyclosporin A and hexachlorobenzene, Regulatory Toxicology and Pharmacology 36(1):12-21
  • Weichert M and Hothorn LA (2002) Robust hybrid tests for the two-sample location problem, Communications in Statistics - Simulation and Computation 31:175-187
  • Bauer P, Hothorn LA, Westfall P (2001) Special issue multiple comparison procedures, Biometrical Journal 43:531
  • Bretz F and Hothorn LA (2001) Testing dose-response relationships with a priori unknown possibly nonmonotone shapes, Journal of Biopharmaceutical Statistics 11:193-207
  • Bretz F, Genz A, Hothorn LA (2001) On the numerical availibilty of multiple comparison procedures, Biometrical Journal 43:645-656
  • Munzel U and Hothorn LA (2001) An unified approach to simultaneous rank test procedures in the unbalanced one-way layout, Biometrical Journal 43:553-559
  • Tamhane AC and Hothorn LA (2001) Letter to the editor: A multiple comparison procedure for the three and four-armed controlled clinical trials, Statistics in Medicine 20:317-321
  • Bretz F and Hothorn LA (2000) A powerful alternative to Williams' test with application to toxicological doseresponse relationships of normally distributed data, Environmental and Ecological Statistics 7:135-154
  • Hothorn LA and Bretz F (2000) One-sided simultaneous confidence intervals for effective dose steps in unbalanced designs, Biometrical Journal 42:995-1006
  • Hothorn LA and Bretz F (2000) Evaluation of animal carcinogenicity studies. Cochran-Armitage trend test vs. multiple contrast tests, Biometrical Journal 42:553-567
  • Hothorn LA and Hauschke D (2000) Identifying the maximum safe dose: a multiple testing approach, Journal of Biopharmaceutical Statistics 10:15-30
  • Hothorn LA, Hayashi M, Seidel D (2000) Dose-response relationships in mutagenicity assays including an appropriate positive control group: a multiple testing approach, Environmental and Ecological Statistics 7:27-42
  • Lehmacher W, Kieser M, Hothorn LA (2000) Sequential and multiple testing for dose-response analysis, Drug Information Journal 34:591-597
  • Neuhäuser M and Hothorn LA (2000) Parametric location-scale and scale trend tests based on Levene’s transformation, Computational Statistics and Data Analysis 33:189-200
  • Neuhäuser M, Seidel D, Hothorn LA (2000) Robust trend tests with application to toxicology, Environmental and Ecological Statistics 7:43-56
  • Hauschke D, Kieser M, Hothorn LA (1999) Proof of safety in toxicology based on the ratio of two means for normally distributed data, Biometrical Journal 41:295-304
  • Hothorn LA (1999) Trend tests in epidemiology: p-values or confidence intervals?, Biometrical Journal 41:817-825
  • Koch H-F and Hothorn LA (1999) Exact unconditional distributions for dichotomous data in many-to-one comparisons, Journal of Statistical Planning and Inference 82(1-2):83-99
  • Neuhäuser M and Hothorn LA (1999) An exact Cochran-Armitage test for trend when dose-response shapes are a priori unknown, Computational Statistics and Data Analysis 30:403-412
  • Bauer P, Röhmel J, Maurer W, Hothorn LA (1998) Testing strategies in multi-dose experiments including active control, Statistics in Medicine 17(18):2133-2146
  • Bolte R, Walz M, Lehmann KJ, Hothorn T, Brill C, Hothorn LA, Georgi M (1998) Teleradiology: results of a questionnaire of German radiologists, Journal of Telemedicine and Telecare 4 Suppl 1:69-71
  • Fairweather WR, Bhattacharyya A, Ceuppens PP, Heimann G, Hothorn LA, Kodell RL, Lin KK, Mager H, Middleton BJ, Slob W, Soper KA, Stallard N, Ventre J, Wright J (1998) Biostatistical Methodology in Carcinogenicity Studies, Drug Information Journal 32:401-421
  • Lalla S, Hothorn LA, Haag N, Bader R, Bauss F (1998) Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats, Osteoporosis International 8(2):97-103
  • Neuhäuser M and Hothorn LA (1998) An analogue of Jonckheere’s trend test for parametric and dichotomous data, Biometrical Journal 40:11-19
  • Neuhäuser M, Liu P-Y, Hothorn LA (1998) Nonparametric tests for trend: Jonckheere’s test, a modification and a maximum test, Biometrical Journal 40:899-909
  • Hothorn LA (1997) Modifications of the closure principle for analyzing toxicological studies, Drug Information Journal 30(2):403-412
  • Hothorn LA and Martin U (1997) Application of adaptive interim analysis in pharmacology, Drug Information Journal 30(2):615-619
  • Hothorn LA, Lin KK, Hamada C, Rebel W (1997) Recommendations for Biostatistics of Repeated Toxicity Studies, Drug Information Journal 30(2):327-334
  • Hothorn LA, Neuhäuser M, Koch H-F (1997) Analysis of randomized dose-finding studies: closure test modifications based on multiple contrast tests, Biometrical Journal 39:467-479
  • Kropf S, Hothorn LA, Läuter J (1997) Multivariate many-to-one procedures with applications to pre-clinical trials, Drug Information Journal 30(2):433-447
  • Neuhäuser M and Hothorn LA (1997) The control of consumer’s risk in the Ames mutagenicity assay, Drug Information Journal 30(2):363-367
  • Neuhäuser M and Hothorn LA (1997) Trend tests for dichotomous endpoints with application in carcinogenicity studies, Drug Information Journal 30(2):463-469
  • Hauschke D, Steinjans VW, Hothorn LA (1996) A note on Welch’s approximate t-solution to bioequivalence assessment, Biometrika 83:236-237
  • Hothorn LA (1994) Multiple Comparisons in Long-Term Toxicity Studies, Environmental Health Perspectives 102 Suppl 1:33-38
  • Hothorn LA (1994) Biostatistical analysis of the micronucleus mutagenicity assay based on the assumption of a mixing distribution, Environmental Health Perspectives 102 Suppl 1:121-125
  • Hothorn LA and Hajian G (1994) Biostatistical Aspects of Toxicokinetics, Drug Information Journal 28:187-190
  • Hothorn LA and Lehmacher W (1991) A simple testing procedure 'control versus k treatments' for one-sided ordered alternatives, Biometrical Journal 33:179-189
  • Kälble T, Tricker AR, Berger M, Amelung F, Waldherr R, Hothorn L, Möhring K, Staehler G (1991) Tumor induction in a rat model for ureterosigmoidostomy without evidence of nitrosamine formation, Journal of Urology 146(3):862-866
  • Solecki R, Hothorn LA, Holzweissig M, Heinrich V (1991) Computerised analysis of pathological findings in longterm trials with Phenylmeruric acetate in rats, Archives of Toxicology Supplement 14:100-103
  • Hothorn LA (1989) A simple statistical procedure for testing tumour rates in animal carcinogenicity experiments, Archives of Toxicology Supplement 13:265-268
  • Hothorn LA (1989) Robustness study on Williams and Shirley procedure, with application in toxicology, Biometrical Journal 31:891-903
  • Hothorn LA (1989) On the behaviour of Fligner/Wolfe trend test 'control versus k treatments', with application in toxicology, Biometrical Journal 31:767-780

Journale

  • Bader A, Bintig W, Begandt D, Klett A, Siller IG, Gregor C, Schaarschmidt F, Weksler B, Romero I, Couraud PO, Hell SW, Ngezahayo A. (2017) Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through CNG channels., J Physiol.
    DOI: 10.1113/JP273150
  • Berthoud VM, Ngezahayo A. (2017) Focus on lens connexins., BMC Cell Biol.
    DOI: 10.1186/s12860-016-0116-6.
  • Berthoud VM, Ngezahayo A. (2017) Focus on lens connexins., BMC Cell Biol. 2017 Jan 17;18(Suppl 1):6
    DOI: 10.1186/s12860-016-0116-6
  • Harting T, Stubbendorff M, Willenbrock S, Wagner S, Schadzek P, Ngezahayo A, Murua Escobar HM, Nolte I. (2017) The effect of dichloroacetate in canine prostate adenocarcinomas and transitional cell carcinomas in vitro., Int J Oncol. 2016 Dec;49(6):2341-2350
    DOI: 10.3892/ijo.2016.3720
  • Harting TP, Stubbendorff M, Hammer SC, Schadzek P, Ngezahayo A, Murua Escobar H, Nolte I. (2017) Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines., PLoS One. 2017 Jun 7;12(6)
    DOI: 10.1371/journal.pone.0178744
  • Blödow A, Begandt D, Bader A, Becker A, Burghard A, Kühne D, Kral A, Ngezahayo A. (2016) ATP-sensitive K(+) channels (Kir6.1/SUR1) regulate gap junctional coupling in cochlear-supporting cells., Pflugers Arch. 2016 Jul;468(7):1215-22.
    DOI: 10.1007/s00424-016-1815-8.
  • Hammer SC, Becker A, Rateitschak K, Mohr A, Lüder Ripoli F, Hennecke S, Junginger J, Hewicker-Trautwein M, Brenig B, Ngezahayo A, Nolte I, Murua Escobar H. (2016) Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines., Int J Mol Sci.
  • Harting T, Stubbendorff M, Willenbrock S, Wagner S, Schadzek P, Ngezahayo A, Escobar HM, Nolte I (2016) The effect of dichloroacetate in canine prostate adenocarcinomas and transitional cell carcinomas in vitro., Int J Oncol.
    DOI: 10.3892/ijo.2016.3720
  • Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T. (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1., Hepatology. 2016
    DOI: 10.1002/hep.28111
  • Schadzek P, Schlingmann B, Schaarschmidt F, Lindner J, Koval M, Heisterkamp A, Preller M, Ngezahayo A. (2016) The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels., Biochim Biophys Acta. 2016 Jan;1858(1):57-66.
    DOI: 10.1016/j.bbamem.2015.10.001.
  • Begandt D, Bader A, Antonopoulos GC, Schomaker M, Kalies S, Meyer H, Ripken T, Ngezahayo A. (2015) Gold nanoparticle-mediated (GNOME) laser perforation: a new method for a high-throughput analysis of gap junction intercellular coupling., J Bioenerg Biomembr.
    DOI: 10.1007/s10863-015-9623-y
  • Hermane J, Bułyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A. (2015) New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90., Chembiochem.
    DOI: doi: 10.1002/cbic.201402375
  • Kniggendorf AK, Meinhardt-Wollweber M, Yuan X, Roth B, Seifert A, Fertig N, Zeilinger C (2014) Temperature-sensitive gating of hCx26: high-resolution Raman spectroscopy sheds light on conformational changes., Biomed Opt Express
    DOI: 10.1364/BOE.5.002054
  • Schax E, Walter JG, Märzhäuser H, Stahl F, Scheper T, Agard DA, Eichner S, Kirschning A, Zeilinger C (2014) Microarray-based screening of heat shock protein inhibitors., J Biotechnol
    DOI: 10.1016/j.jbiotec.2014.03.006
  • Schomaker M, Killian D, Willenbrock S, Heinemann D, Kalies S, Ngezahayo A, Nolte I, Ripken T, Junghanß C, Meyer H, Escobar HM, Heisterkamp A (2014) Biophysical effects in off-resonant gold nanoparticle mediated (GNOME) laser transfection of cell lines, primary- and stem cells using fs laser pulses., J Biophotonics. doi: 10.1002/jbio.201400065
  • Begandt D., Bader A., Dreyer L., Eisert N., Reeck T., Ngezahayo A. (2013) Biphasic increase of gap junction coupling induced by dipyridamole in the rat aortic A-10 vascular smooth muscle cell line., J. Cell. Comm. Signal. 7:151-160
  • Begandt D., Bader A., Gerhard L, Lindner J, Dreyer L., Sclingmann B., Ngezahayo A. (2013) Dipyridamole-related enhancement of gap junction coupling in the GM-7373 aortic endothelial cells correlates with an increase in the amount of connexin 43 mRNA and protein as well as gap junction plaques. , J. Bioenerg. Biomembr. 45:409-419
  • Meyer W, Oberthuer A, Ngezahayo A, Neumann U, Jacob R. (2013) Immunohistochemical demonstration of connexins in the developing feather follicle of the chicken., Acta Histochem. 2013 Dec 14. pii: S0065-1281(13)00233-X. doi: 10.1016/j.acthis.2013.11.01
  • Moulay M, Liu W, Willenbrock S, Sterenczak KA, Carlson R, Ngezahayo A, Murua Escobar H, Nolte I. (2013) Evaluation of stem cell marker gene expression in canine prostate carcinoma- and prostate cyst-derived cell lines., Anticancer Res. 33:5421-5431.
  • Schlie-Wolter S, Ngezahayo A., Chichkov B N (2013) The selective role of ECM components on cell adhesion, morphology, proliferation and communication in vitro., Exp Cell Res. 319:1553-1561
  • Schlingmann B., Schadzek P., Hemmerling F. Schaarschmidt F., Heisterkamp A., Ngezahayo A. (2013) The role of the C-terminus in functional expression and internalization of rat connexin46 (rCx46). , J. Bioenerg. Biomembr. 45:59-70
  • Schlingmann B., Schadzek P., Busko S., Heisterkamp A., Ngezahayo A. (2012) Cataract-associated D3Y mutation of human connexin46 (hCx46) increases the dye coupling of gap junction channels and suppresses the voltage sensitivity of hemichannels, J. Bioenerg. Biomembr. 44:607-614
  • L Dreyer B Krolitzki R Autschbach P Vogt T Welte A Ngezahayo B Glasmacher (2011) An Advanced Cone-And-Plate Reactor for the in vitro-Application of Shear Stress on Adherent Cells., Clin Hemorheol Microcirc. (in print)
  • M. Pangalos, W. Bintig, B. Schlingmann, F. Feyerabend, F. Witte, D. Begandt, A. Heisterkamp, and A. Ngezahayo (2011) Action potentials in primary osteoblasts and in the MG-63 osteoblast-like cell line, J Bioenerg Biomembr
  • J. Baumgart, W. Bintig, A. Ngezahayo, H. Lubatschowski, and A. Heisterkamp (2010) Fs-laser-induced Ca2+ concentration change during membrane perforation for cell transfection, Optics express | Datei |
  • A. Ovsianikov, M. Malinauskas, S. Schlie, S. Gittard, R. Naraya, M- Löbler, K. Sternberg, K.-P. Schmitz, A. Ngezahayo, and B.N. Chichkov (2009) Two-photon polymerisation of Poly(Ethylene Glycol) materials for biomedical applications, to be submitted
  • D. Begandt, W. Bintig, K. Oberheide, S. Schlie, and A. Ngezahayo (2009) Dipyridamole increases gap junction coupling in bovine GM-7373 aortic endothelial cells by a cAMP-protein kinase A dependent pathway, J Bioenerg Biomembr | Datei |
  • E. Fadeeva, S. Schlie, J. Koch, A.Y. Vorobyev, C. Guo, and B.N. Chichkov (2009) Femtosecond laser-induced surface structures on platinum and their effects on hydrophobicity and fibroblast cell proliferation, Textbook
  • J. Baumgart, K. Kuetemeyer, W. Bintig, A. Ngezahayo, W. Ertmer, H. Lubatschowski, and A. Heisterkamp (2009) Repetition rate dependency of reactive oxygen species formation during femtosecond laser-based cell surgery, J Biomed Opt
  • S. Schlie, E. Fadeeva, A. Ngezahayo, and B.N. Chichkov (2009) Biophysical characterisation of adhesion mechanism in dependence of material wettability, Biophysical characterisation of adhesion mechanism in dependence of material wettability
  • W. Bintig, J. Baumgart, W. J. Walter, A. Heisterkamp, H. Lubatschowski, and A. Ngezahayo (2009) Purinergic signalling in rat GFSHR-17 granulosa cells: an in vitro model of granulosa cells in maturing follicles, Journal of Bioenergetics and Biomembranes | Datei |
  • E. Fadeeva, S. Schlie, J. Koch, A. Ngezahayo, and B.N. Chichkov (2008) The hydrophobic properties of femtosecond laser fabricated spike structures and their effects on cell proliferation., Physica Status Solidi | Datei |
  • J. Baumgart, W. Bintig, A. Ngezahayo, S. Willenbrock, H. Murua Escobar, W. Ertmer, H. Lubatschowski, and A. Heisterkamp (2008) Quantified femtosecond laser based opto-perforation of living GFSHR-17 and MTH53 a cells., Optics Express | Datei |
  • W. J. Walter, C. Zeilinger, W. Bintig, H.-A. Kolb, and A. Ngezahayo (2008) Phosphorylation in the C-Terminus of the Rat Connexin 46 (rCx46) and Regulaton of the Conducting Activity of the Formed Connexons, Journal of Bioenergetics and Biomembranes | Datei |
  • A. Heisterkamp, J. Baumgart, I.Z. Maxwell, A. Ngezahayo, E. Mazur, and H. Lubatschowski (2007) Fs-laser scissors for photobleaching, ablation in fixed samples and living cells, and studies of cell mechanics., Methods Cell Biol
  • A. Ovsianikov, S. Schlie, A. Ngezahayo, A. Haverich, and B.N. Chichkov (2007) Two-photon polymerizations technique for microfabrication of CAD designed three-dimensional polymeric scaffolds., J. Tissue Eng. a. Regenerative Med. | Datei |
  • R. Pätzold, M. Keuntje, K. Theophile, J. Müller, E. Mielcarek, A. Ngezahayo, and A. Anders-von Ahlften (2007) In situ mapping of nitrifiers and anammox bacteria in microbial aggregates by means of confocal resonance Raman microscopy. | Datei |
  • S. Schlie, A. Ngezahayo, A. Ovsianikov, T. Fabian, H.A. Kolb, H. Haferkamp, and B.N. Chichkov (2007) Three-dimensional cell growth on structures fabricated from ORMOCER® by two-photon polymerisation technique., J. Biomater. Applic. | Datei |
  • W. Bintig, V. Buchholz, S. Schlie, J. Baumgart, A. Heisterkamp, and A. Ngezahayo (2007) Gap Junction hemichannels of GFSHR-17 granulosa cells are mechano-sensitive, Acta Physiologica
  • J. Baumgart, A. Heisterkamp,A. Ngezahayo, W. Ertmer,H. Lubatschowski (2006) Cell surgery by fs-laser pulses, Proc. SPIE, Commercial and Biomedical Applications of Ultrafast Lasers VII
  • A. Ngezahayo, B. Altmann, M. Steffens, and H.A. Kolb (2005) Gap Junction Coupling and Apoptosis in GFSHR-17 Granulosa Cells., J. Membr. Biol. | Datei |
  • M. Debarry, I. Marten, A. Ngezahayo, and H.A. Kolb (2004) Differential defense responses in sweet potato suspension culture., Plant Sci. | Datei |
  • O. Enders, A. Ngezahayo, M. Wiechmann, F. Leisten, and H.A. Kolb (2004) Structural calorimetry of main transition of supported DMPC bilayers by temperature controlled AFM., Biophys. J. | Datei |
  • S. Breidert, R. Jakob, A. Ngezahayo, H.A. Kolb, and H.Y. Naim (2004) Trafficking pathways of Cx49-GFP in living mammalian cells., Biol. Chem. | Datei |
  • A. Blödow, A. Ngezahayo, A. Ernst, and H.A. Kolb (2003) Calmodulin antagonists suppress gap junction coupling in isolated Hensen cells of the guinea pig cochlea., Pflügers Arch. | Datei |
  • A. Ngezahayo, B. Altmann, and H.A. Kolb (2003) Regulation of gap junctional coupling, ion fluxes and cell volume by cGMP in GFSHR-17 granulosa cells., J. Membr. Biol. | Datei |
  • I. Todt, A. Ngezahayo, A. Ernst, and H.A. Kolb (2001) Hydrogen peroxide inhibits gap junctional coupling and modulates intracellular free calcium in cochlear Hensen cells., J. Membr. Biol. | Datei |
  • A. Ngezahayo, M. Schachner, and A. Artola (2000) Synaptic Activity Modulates the Induction of Bidirectional Synaptic Changes in Adult Mouse Hippocampus., J. Neurosci. | Datei |
  • B. Jedamzik, I. Marten, A. Ngezahayo, A. Ernst, and H.A. Kolb (2000) Regulation of Lens rCx46-formed Hemichannels by Activation of Protein Kinase C, External Ca2+ and Protons., J. Membr. Biol. | Datei |
  • I. Todt, A. Ngezahayo, A. Ernst, and H.A. Kolb (1999) Inhibition of gap junctional coupling in cochlear supporting cells by gentamicin., Pflügers Arch. | Datei |
  • A. Ngezahayo, C. Zeilinger, I. Todt, I. Marten, and H.A. Kolb (1998) Inactivation of expressed and conducting rCx46 hemichannels by phosphorylation., Pflügers Arch. | Datei |
  • A. Ngezahayo, F. Lang, and H.A. Kolb (1995) Cholecystokinin-octapeptide affects the fluorescence signal of a single pancreatic acinar cell loaded with the acrylodan-labelled MARCKS peptide, a protein kinase C substrate., Pflügers Arch.
  • A. Ngezahayo and H.A. Kolb (1994) Regulation of gap junctional coupling in isolated pancreatic acinar cell pairs by cholecystokinin-octapeptide, vasoactive intestinal peptide (VIP) and a VIP-antagonist., J. Membr. Biol.
  • B. Hartmann, A. Ngezahayo, B. Heller, A. Jalowy, V. Burkart, and H.A. Kolb (1994) Nitric oxide toxicity in pancreatic islet cells: role of protein biosynthesis, calcium influx and arachidonic acid metabolism., Biochem. Soc. Trans.
  • A. Ngezahayo and H.A. Kolb (1993) Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells., Pflügers Archiv.
  • A. Ngezahayo and H.A. Kolb (1990) Gap junctional permeability is affected by cell volume changes and modulates volume regulation., FEBS Lett. | Datei |

Review

  • Wagner S, Ngezahayo A, Murua Escobar H, Nolte I (2014) Role of miRNA let-7 and its major targets in prostate cancer, Biomed Res Int. 2014; 2014: 376326.

Bücher

  • Hothorn LA (2015) Statistics in Toxicology Using R, Chapman and Hall/CRC
    ISBN: 9781498701273 CAT# K24557
  • Hothorn LA (ed.) (1991) Modern Statistical Methods in Toxicology, Lecture Notes in Medical Informatics, Vol. 41, Springer
  • Hothorn LA (1990) Probleme der Toxikologie Vol. 5, Verlag Volk und Gesundheit, Berlin

Buchkapitel

  • Reichl FX and Schwenk M (ed) (2014) Regulatory Toxicology. Chapter: Statistical Evaluation Methods in Toxicology, Springer Heidelberg 213-223
  • Marquardt H, Schäfer SG, Barth H (Hrsg.) (2013) Lehrbuch der Toxikologie, Wissenschaftliche Verlagsgesellschaft Stuttgart, vollständig überarbeitete und erweiterte Auflage ISBN 978-3-8047-2876-9 darin: Biometrie
  • Lin D, Djira GD, Shkedy Z, Burzykowski T, Hothorn LA (2012) Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test, Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R Use R!, 2012, Part 2, 249-258
  • Lin D, Hothorn LA, Djira GD, Bretz F (2012) Multiple Contrasts Test for Testing Dose-Response under Order-Restricted Alternatives. In: Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R, Use R! 233-248, DOI: 10.1007/978-3-642-24007-2_16
  • Lin D, Yekutieli D, Djira GD, Hothorn LA (2012) Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement Rate, Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R. Use R! 259-267 DOI: 10.1007/978-3-642-24007-2_16
  • Reichl FX und Schwenk M (2004) , Springer Heidelberg, Darin: 2.3.1 Statistische Auswerteverfahren
  • Marquardt H und Schäfer SG (2003) Lehrbuch Toxikologie. Darin: Biostatistik, Wissenschaftliche Verlagsgesellschaft
  • Bretz F and Hothorn LA (2001) Multiple comparisons in repeated measures designs, with biomedical applications. In: Mathematical Statistics with Applications in Biometry, Festschrift in honour of S. Schach, eds. J. Kunert, G. Trenkler. J. Eul. Verlag Lohmar 303-312
  • Hauschke D and Hothorn LA (1998) Safety assessment in toxicology studies: proof of safety versus proof of hazard, Chow, S.- C. and Liu, J.-P. (eds.): Design and analysis of animal studies in pharmaceutical development. Chapter 6. Marcel Dekker, New York, 197-226
  • Hothorn LA and Hauschke D (1998) Statistical Testing Principles in Randomized Toxicological Studies, Chow, S.-C. and Liu, J.-P. (eds.): Design and analysis of animal studies in pharmaceutical development. Chapter 4. Marcel Dekker, New York, 79-134
  • Rasch D et al. (eds.) (1998) Verfahrensbibliothek Versuchsplanung und –auswertung Band II. Mitarbeit an mehreren Verfahren (Hothorn LA), R. Oldenburg Verlag München
  • Hothorn LA (1997) New statistical methods for analyzing mutagenicity assays: real data problems in biopharmeceutical drug development, Kitsos, C.P.; Edler, L. (eds.): Industrial statistics. Physica Verlag Heidelberg, 201-208
  • Hothorn LA, Hauschke D, Senn SJ, Lehmacher W (1997) Pro’s and con’s of cross-over trials, Vollmar, J; Hothorn LA (Eds.) Cross-over clinical trials. Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 97
  • Hothorn LA, Hauschke D, Senn SJ, Lehmacher W (1997) Cross-over trials: references of the last six years, Vollmar, J; Hothorn LA (Eds.) Cross-over clinical trials. Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 73-96
  • Neuhäuser M and Hothorn LA (1997) Adaptive tests for trend, Kitsos, C.P.; Edler, L. (eds.): Industrial statistics. Physica Verlag Heidelberg, 269-273.
  • Vollmar J and Hothorn LA (Eds.) (1997) Cross-over clinical trials, Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 1-97
  • Hajian G and Hothorn LA (1995) Biostatistical aspects of concomitant toxicokinetics, Vollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6, Fischer Verlag Stuttgart, 115-133
  • Hothorn LA (1995) Biostatistical analysis of the experimental design ‘control versus k treatments’ including a positive control group, Vollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6; Fischer Verlag Stuttgart, 19-26
  • Maurer W, Hothorn LA, Lehmacher W (1995) Multiple comparisons in drug clinical trials and preclinical assays: a-priori ordered hypotheses, Vollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6; Fischer Verlag Stuttgart, 3-18
  • Ortseifen C and Hothorn LA (1995) Multiple Vergleiche ‘Kontrolle gegen k Behandlungen’ bei Abweichung von den ANOVA-Annahmen, Vollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6, Fischer Verlag Stuttgart, 77-100
  • Marquardt H und Schäfer SG (1994) Lehrbuch der Toxikologie. Darin: Biometrie, Wissenschaftsverlag Mannheim 15-31
  • Hothorn LA (1992) Sample size estimation for several trend tests in the k-sample problem, Computational Statistics. (Ed.: Dodge,Y. and Whittaker,J.), Physica-Verlag Heidelberg, Vol. 2; 387-390
  • Hothorn LA and Nagel M (1992) Eine Software-Umgebung zur kombinierten exploratorischen und konfirmatorischen Datenanalyse bei multivariaten Fragestellungen in präklinischen und klinischen Studien, Methoden und Werkzeuge für die exploratorische Datenanalyse in den Biowissenschaften. G. Fischer, Stuttgart
  • Nagel M, Hothorn LA, Hartmann P (1992) Hochinteraktive Datenanalyse- Werkzeuge und Prinzipien, Methoden und Werkzeuge für die exploratorische Datenanalyse in den Biowissenschaften. G. Fischer, Stuttgart

Tagungsbeiträge

  • Menke S, Poehling HM, Gerhard D (2011) Application of generalized linear model based multiple comparison procedures to greenhouse pest control experiments, Acta Horticulturae 893:1233-1238
  • Gerhard D and Schaarschmidt F (2007) Proof of safety for non-target species: a confidence interval approach. Proceedings of the International Symposium Agricultural Field Trials – Today and Tomorrow, Stuttgart-Hohenheim: 37-43

Abschlussarbeiten

  • Domes HS (2016) Validity of Confidence Intervals in Case of Model Selection Uncertainty, M.Sc. Thesis | Datei |
  • Pallmann P (2016) Multiple Contrast Tests with Repeated and Multiple Endpoints|with Biological Applications, Ph.D. Thesis | Datei |
  • Schaarschmidt F (2016) Simultane Konfidenzintervalle für multiple Vergleiche - Ansätze für nicht Gauß-verteilte Daten und Inferenz in linearen Modellen, Habil | Datei |
  • Kitsche A (2014) Evaluation of interaction effects in two-factorial designs by simultaneous confidence intervals in the cell means model, Ph.D. Thesis | Datei |
  • Gerhard D (2010) Simultaneous small sample inference based on profile likelihood, Ph.D. Thesis | Datei |
  • Scherer R (2010) Simultaneous Confidence Intervals for Biodiversity Indices with Application to Overdispersed Multinomial Count Data, M.Sc. Thesis | Datei |
  • Schmidt M (2010) Multiple comparisons of populations based on genetic marker data, M.Sc. Thesis | Datei |
  • Hasler M (2009) Extensions of Multiple Contrast Tests, Ph.D. Thesis | Datei |
  • Mi X (2009) Model Selection Procedure with Familywise Error Rate Control for Binomial Order-Restricted Problems, Ph.D. Thesis | Datei |
  • Schaarschmidt F (2009) Marginal and simultaneous confidence intervals for abundance data with applications to safety assessment of non-target species, Ph.D. Thesis | Datei |
  • Menke S (2008) Einfluss von Neem Azal-U und Neem-Pellet auf Trialeurodes vaporariorum und Encarsia formosa unter besonderer Berücksichtigung der biostatistischen Bewertung der Versuchsdaten mittels Generalisierter Linearer Modelle, M.Sc Thesis | Datei |
  • Frömke C (2006) Relevance-shifted tests for high dimensional data with small sample sizes, Ph.D. Thesis | Datei |
  • Gerhard D (2006) Poisson confidence intervals for testing the equality of abundance data in generalized linear models, Diplomarbeit | Datei |
  • Dilba G (2005) Simultaneous Inference for Ratios of Location Parameters, Ph.D. Thesis | Datei |
  • Schaarschmidt F (2005) Binomial group testing – Design and Analysis, Diplomarbeit | Datei |
  • Ma D (2004) Small Sample Inference For The Two-Sample Design, M.Sc. Thesis | Datei |
  • Bretz F (2003) Planung und Auswertung von Dosis-Wirkungs-Studien unter Verwendung von multiplen Testprozeduren, Ph.D. Thesis | Datei |
  • Biesheuvel EHE (2002) Many-to-one comparisons in stratified designs, Ph.D. Thesis | Datei |
  • Frömke C (2001) Simultaneous tests and confidence intervals for experimental agricultural designs, Diplomarbeit | Datei |
  • Seidel D (2000) Trendtests für geordnete kategoriale Daten bei sehr kleinen Fallzahlen, Ph.D. Thesis | Datei |
  • Bretz F (1999) Powerful Modifications of Williams' Test on Trend, Ph.D. Thesis | Datei |
  • Hauschke D (1999) Biometrische Methoden zur Planung und Auswertung von Sicherheitsstudien, Ph.D. Thesis | Datei |