Leibniz Universität Hannover Faculty Faculty of Natural Sciences
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Peer-reviewed journals

  • Menssen M, Schaarschmidt F (2019) Prediction intervals for overdispersed binomial data with application to historical controls,  Statistics in Medicine 18(3)275-398
    DOI: 10.1002/sim.8124
  • Schadzek P, Stahl Y, Preller M, Ngezahayo A (2019) Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation,  FEBS Open Bio (in press)
    DOI: 10.1002/2211-5463.12624
  • Becker A, Leskau M, Schlingmann-Molina B, Hohmeier S, Alnajjar S, Murua Escobar H, Ngezahayo A (2018) Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique,  Scient Rep (2018)8:14963
    DOI: 10.1038/s41598-018-33392-0
  • Gretzinger S, Beckert N, Gleadall A, Lee-Thedieck C, Hubbuch J (2018) 3D bioprinting–Flow cytometry as analytical strategy for 3D cell structures,  Biopr 11, e00023
    DOI: 10.1016/j.BPRINT.2018.e00023
  • Klaus A, Strube C, Röper KM, Radespiel U, Schaarschmidt F, Nathan S, Goossens B, Zimmermann E (2018) Fecal parasite risk in the endangered proboscis monkey is higher in an anthropogenically managed forest environment compared to a riparian rain forest in Sabah, Borneo,  PLOS ONE
    DOI: 10.1371/journal.pone.0195584
  • Klein A, Zimmerman E, Radespiel, U, Schaarschmidt F, Springer A, Strube C (2018) Ectoparasite communities of small-bodied Malagasy primates: seasonal and socioecological influences on tick, mite and lice infestation of Microcebus murinus and M. ravelobensis in northwestern Madagascar,  Parasites & Vectors 11
    DOI: 10.1186/s13071-018-3034-y
  • Kratzer D, Ludwig-Husemann A, Junges K, Geckle U, Lee-Thedieck C (2018) Nanostructured Bifunctional Hydrogels as Potential Instructing Platform for Hematopoietic Stem Cell Differentiation,  Front in Mat 5, 81
    ISBN: ISSN: 2296-8016
  • Nargang TM, Dierkes R, Bruchmann J, Keller N, Sachsenheimer K, Lee-Thedieck C, Kotz F, Helmer D, Rapp BE (2018) Photolithographic structuring of soft, extremely foldable and autoclavable hydrophobic barriers in paper,  Anal Meth 10:4028-4035
    DOI: 10.1039/C8AY01010B
  • Raic A, Naolou T, Mohra A, Chatterjee C, Lee-Thedieck C (2018) 3D models of the bone marrow in health and disease: yesterday, today, and tomorrow,  MRS Communications, 1-16
    DOI: 10.1557/mrc.2018.203
  • Raic A, Riedel S, Kemmling E, Bieback K, Overhage J, Lee-Thedieck C (2018) Biomimetic 3D in vitro model of biofilm triggered osteomyelitis for investigating hematopoiesis during bone marrow infections,  Acta biomaterialia 73, 250-262
    DOI: 10.1016/j.actbio.2018.04.024
  • Rödling L, Volz EM, Raic A, Brändle K, Franzreb M, Lee‐Thedieck C (2018) Magnetic macroporous hydrogels as a novel approach for perfused stem cell culture in 3d scaffolds via contactless motion control,  Adv healthc mat 7(9)1701403
    DOI: 10.1002/adhm.201701403
  • Schadzek P, Hermes D, Stahl Y, Dilger N, Ngezahayo A (2018) Concatenation of human connexin26 (hCx26) and human connexin46 (hCx46) for the analysis of heteromeric gap junction hemichannels and heterotypic gap junction channels,  Int J Mol Sci 19(9)2742
    DOI: 10.3390/ijms19092742
  • Sybertz J, Matthies A, Schaarschmidt F, Reich M, von Haaren C (2018) Assessing the value of field margins for butterflies and plants: how to document and enhance biodiversity at the farm scale,  Agriculture, Ecosystems and Environment 249, 165-176
    DOI: 10.1016/j.agee.2017.08.018
  • Bader A, Bintig W, Begandt D, Klett A, Siller IG, Gregor C, Schaarschmidt F, Weksler B, Romero I, Couraud PO, Hell SW, Ngezahayo A (2017) Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through CNG channels,  J Physiol 595:2497-2517
    DOI: 10.1113/JP273150
  • Baeßler B, Schaarschmidt F, Treutlein M, Stehning C, Schnackenburg B, Michels G, Maintz D, Bunck AC (2017) Re-evaluation of a novel approach for quantitative myocardial edema detection by analyzing tissue inhomogeneity in acute myocarditis using T2-mapping,  European Radiology 27 (12)
    DOI: 10.1007/s00330-017-4894-9
  • Berthoud VM, Ngezahayo A (2017) Focus on lens connexins,  BMC Cell Biol;18(1):6
    DOI: 10.1186/s12860-016-0116-6
  • Harting TP, Stubbendorff M, Hammer SC, Schadzek P, Ngezahayo A, Murua Escobar H, Nolte I (2017) Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines,  PLoS One June 7
    DOI: 10.1371/journal.pone.0178744
  • Jensen SM, Schaarschmidt F, Onofri A, Ritz C (2017) Experimental design matters for statistical analysis: how to handle blocking,  Pest Management Science 74(3), 523-534
    DOI: 10.1002/ps.4773
  • Khamis G, Schaarschmidt F, Papenbrock J (2017) Genetic diversity among populations of the xerophytic tree species Balanites aegyptiaca and its morpho-physiological responses to water deficiency,  African Journal of Agricultural Research 12(45): 3252-3269
    DOI: 10.5897/AJAR2017.12696
  • Matthies SA, Rüter S, Schaarschmidt F, Prasse R (2017) Determinants of species richness within and across taxonomic groups in urban green spaces,  Urban Ecosystems 20: 897-909
    DOI: 10.1007/s11252-017-0642-9
  • Menssen M, Linde M, Otunga Omondi E, Abukutsa-Onyango M, Dinssa FF, Winkelmann T (2017) Genetic and morphological diversity of cowpea (Vigna unguiculata (L.) Walp.) entries from East Africa,  Scientia Horticulturae 226: 268–276
    DOI: 10.1016/j.scienta.2017.08.003
  • Otava M, Sengupta R, Shkedy Z, Hothorn LA, Gerhard D (2017) IsoGeneGUI: Multiple Approaches for Dose-Response Analysis of Microarray Data Using R,  R JOURNAL Volume: 9 Issue: 1 Pages: 14-26
  • Otava M, Shkedy Z, Hothorn LA, Talloen W, Gerhard D, Kasim A (2017) Identification of the Minimum Effective Dose for Normally Distributed Data Using a Bayesian Variable Selection Approach,  Journal of Biopharmaceutical Statistics
    DOI: 10.1080/10543406.2017.1295247
  • Rödling L, Schwedhelm I, Kraus S, Bieback K, Hansmann J, Lee-Thedieck C (2017) 3D models of the hematopoietic stem cell niche under steady-state and active conditions,  Sci rep 7(1)4625
    DOI: 10.1038/s41598-017-04808-0
  • Schaarschmidt F (2017) Multiple treatment comparisons in analysis of covariance with interaction,  Statistical Methods and Applications 26, 609-628
    DOI: 10.1007/s10260-017-0383-1
  • Turner S, Meyer-Stüve S, Schippers A, Guggenberger G, Schaarschmidt F, Wild B, Richter A, Dohrmann R, Mikutta R (2017) Microbial utilization of mineral-associated nitrogen in soils,  Soil Biology and Biochemistry 104, 185–196
    DOI: 10.1016/j.soilbio.2016.10.010
  • Turner S, Mikutta R, Meyer-Stüve S, Guggenberger G, Schaarschmidt F, Lazar CS, Dohrmann R, Schippers A (2017) Microbial Community Dynamics in Soil Depth Profiles Over 120,000 Years of Ecosystem Development,  Front. Microbiol. 8:874
    DOI: 10.3389/fmicb.2017.00874
  • Winkler AL, Koenig M, Welle A, Trouillet V, Kratzer D, Hussal C, Lahann J, Lee-Thedieck C (2017) Bioinstructive Coatings for Hematopoietic Stem Cell Expansion Based on Chemical Vapor Deposition Copolymerization,  Biomacromol 18(10)3089-3098
    DOI: 10.1021/acs.biomac.7b00743
  • Winkler AL, Von Wulffen J, Rödling L, Raic A, Reinartz I, Schug A, Gralla‐Koser R, Geckle U, Welle A, Lee‐Thedieck C (2017) Significance of Nanopatterned and Clustered DLL1 for Hematopoietic Stem Cell Proliferation,  Adv Func Mat 27(21)1606495
    DOI: 10.1002/adfm.201606495
  • Baeßler B, Schaarschmidt F, Stehning C, Schnackenburg B, Giolda A, Maintz D, Bunck AC (2016) Reproducibility of three different cardiac T2 -mapping sequences at 1.5T,  J Magn Reson Imaging. 44(5)
    DOI: 10.1002/jmri.25258
  • Baessler B, Schaarschmidt F, Dick A, Michels G, Maintz D, Bunck AC (2016) Diagnostic implications of magnetic resonance feature tracking derived myocardial strain parameters in acute myocarditis,  European Journal of Radiology 85(1), 218-227
    DOI: 10.1016/j.ejrad.2015.11.023
  • Bischoff N, Mikutta R, Shibistova O, Puzanov A, Reichert E, Silanteva M, Grebennikova A, Schaarschmidt F, Heinicke S, Guggenberger G (2016) Land-use change under different climatic conditions: Consequences for organic matter and microbial communities in Siberian steppe soils,  Agriculture, Ecosystems & Environment 235, 253–264
    DOI: 10.1016/j.agee.2016.10.022
  • Blödow A, Begandt D, Bader A, Becker A, Burghard A, Kühne D, Kral A, Ngezahayo A (2016) ATP-sensitive K+ channels (Kir6.1/SUR1) regulate gap junctional coupling in cochlear-supporting cells,  Pflugers Arch 468(7):1215-1222
    DOI: 10.1007/s00424-016-1815-8
  • Große Ruse M, Ritz C, Hothorn LA (2016) Simultaneous inference of a binary composite endpoint and its components,  Journal of Biopharmaceutical Statistics
    DOI: 10.1080/10543406.2016.1148704
  • Hammer SC, Becker A, Rateitschak K, Mohr A, Lüder Ripoli F, Hennecke S, Junginger J, Hewicker-Trautwein M, Brenig B, Ngezahayo A, Nolte I, Murua Escobar H (2016) Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines,  Int J Mol Sci 17(10)1655
    DOI: 10.3390/ijms17101655
  • Hammer SC, Nagel S, Junginger J, Hewicker-Trautwein M, Wagner S, Heisterkamp A, Ngezahayo A, Nolte I, Murua Escobar H (2016) Claudin-1, -3, -4 and -7 gene expression analyses in canine prostate carcinoma and mammary tissue derived cell lines,  Neoplasma 63(2):231-238
    DOI: 10.4149/208_150924N505
  • Harting T, Stubbendorff M, Willenbrock S, Wagner S, Schadzek P, Ngezahayo A, Escobar HM, Nolte I (2016) The effect of dichloroacetate in canine prostate adenocarcinomas and transitional cell carcinomas in vitro,  Int J Oncol 49:2341-2350
    DOI: 10.3892/ijo.2016.3720
  • Hohenbrink S, Schaarschmidt F, Bünemann K, Gerberding S, Zimmermann E, Radespiel U (2016) Female dominance in two basal primates, Microcebus murinus and Microcebus lehilahytsara: variation and determinants,  Animal Behaviour 122, 145-156
    DOI: 10.1016/j.anbehav.2016.10.008
  • Hothorn LA (2016) The two-step approach - a significant ANOVA F-test before Dunnett's comparisons against a control - is not recommended,  Communications in Statistics - Simulation and Computation
    DOI: 10.1080/03610926.2014.902225
  • Khamis G, Winkelmann T, Schaarschmidt F, Papenbrock J (2016) Establishment of an in vitro propagation and transformation system of Balanites aegyptiaca,  Plant Cell Tissue & Organ Culture 125, 3, 457–470
    DOI: 10.1007/s11240-016-0961-1
  • Kitsche A, Ritz C, Hothorn LA (2016) A General Framework for the Evaluation of Genetic Association Studies Using Multiple Marginal Models,  Hum Hered 81:150-172
    DOI: 10.1159/000448477
  • Kniggendorf AK, Nogueira R, Kelb C, Schadzek P, Meinhardt-Wollweber M, Ngezahayo A, Roth B (2016) Confocal Raman microscopy and fluorescent in situ hybridization - A complementary approach for biofilm analysis,  Chemosph 161:112-118
    DOI: 10.1016/j.chemosphere.2016.06.096
  • Leinemann T, Mikutta R, Kalbitz K, Schaarschmidt F, Guggenberger G (2016) Small scale variability of vertical water and dissolved organic matter fluxes in sandy Cambisol subsoils as revealed by segmented suction plates,  Biogeochemistry 131, 1-15
    DOI: 10.1007/s10533-016-0259-8
  • Pallmann P, Hothorn LA (2016) Analysis of means (ANOM): a generalized approach using R,  Journal of Applied Statistics
    DOI: 10.1080/02664763.2015.1117584
  • Pallmann P, Schaarschmidt F (2016) Common pitfalls when testing additivity of treatment mixtures with chi-square analyses,  Journal of Applied Entomology 140 (1-2), 135–141
    DOI: 10.1111/jen.12258
  • Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1,  Hepatology 63(1)49-62
    DOI: 10.1002/hep.28111
  • Rapanas A, Bader A, Klett A, Ngezahayo A, Glasmacher B (2016) The effect of dipyridamole embedded in a drug delivery system made by electrospun nanofibers on aortic endothelial cells,  J Drug Deliv Sci Tech 35:343-352
    DOI: 10.1016/j.jddst.2016.08.011
  • Santiago J, Brandt B, Wildhagen M, Hohmann U, Hothorn LA, Butenko MA, Hothorn M (2016) Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission,  eLife
    DOI: 10.7554/eLife.15075
  • Schaarschmidt F, Djira GD (2016) Simultaneous confidence intervals for ratios of fixed effect parameters in linear mixed models,  Communications in Statistics – Simulation and Computation 45: 1704–1717
    DOI: 10.1080/03610918.2013.849741
  • Schaarschmidt F, Gerhard D, Vogel C (2016) Simultaneous confidence intervals for comparisons of several multinomial samples,  Computational Statistics and Data Analysis 106, 65-76
    DOI: 10.1016/j.csda.2016.09.004
  • Schadzek P, Schlingmann B, Schaarschmidt F, Lindner J, Koval M, Heisterkamp A, Ngezahayo A, Preller M (2016) Data of the molecular dynamics simulations of mutations in the human connexin46 docking interface,  Data Brief 7:93-99
    DOI: 10.1016/j.dib.2016.01.067
  • Schadzek P, Schlingmann B, Schaarschmidt F, Lindner J, Koval M, Heisterkamp A, Preller M, Ngezahayo A (2016) The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels,  Biochimica et Biophysica Acta - Biomembranes 1858 (1):57-66
    DOI: 10.1016/j.bbamem.2015.10.001
  • Schmitt S, Hümmer J, Kraus S, Welle A, Grosjean S, Hanke‐Roos M, Rosenhahn A, Bräse S, Wöll C, Lee‐Thedieck C, Tsotsalas M (2016) Tuning the Cell Adhesion on Biofunctionalized Nanoporous Organic Frameworks,  Adv Funct Mat 26(46)8455-8462
    DOI: 10.1002/adfm.201603054
  • Tischer T, Gralla-Koser R, Trouillet V, Barner L, Barner-Kowollik C, Lee-Thedieck C (2016) Direct mapping of RAFT controlled macromolecular growth on surfaces via single molecule force spectroscopy,  ACS Macro Lett 5(4)498-503
    DOI: 10.1021/acsmacrolett.6b00106
  • Baeßler B, Schaarschmidt F, Dick A, Stehning C, Schnackenburg B, Michels G, Maintz D, Bunck AC (2015) Mapping tissue inhomogeneity in acute myocarditis: a novel analytical approach to quantitative myocardial edema imaging by T2-mapping,  Journal of Cardiovascular Magnetic Resonance. 17:115
    DOI: 10.1186/s12968-015-0217-y
  • Baeßler B, Schaarschmidt F, Schnackenburg B, Stehning C, Giolda A, Maintz D, Bunck AC (2015) Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experiences,  Journal of Cardiovascular Magnetic Resonance. 17:67
    DOI: 10.1186/s12968-015-0177-2
  • Baeßler B, Schaarschmidt F, Stehning C, Schnackenburg B, Maintz D, Bunck AC (2015) A Systematic Evaluation of Three Different Cardiac T2-mapping Sequences at 1.5 and 3T in Healthy Volunteers,  European Journal of Radiology 84(11): 2161-70
    DOI: 10.1016/j.ejrad.2015.08.002
  • Begandt D, Bader A, Antonopoulos GC, Schomaker M, Kalies S, Meyer H, Ripken T, Ngezahayo A (2015) Gold nanoparticle-mediated (GNOME) laser perforation: a new method for a high-throughput analysis of gap junction intercellular coupling,  J Bioenerg Biomembr 47:441-449
    DOI: 10.1007/s10863-015-9623-y
  • Bredemeier B, von Haaren C, Rüter S, Schaarschmidt F, Reich M (2015) Spatial congruence between organic farming and biodiversity related landscape features in Germany,  International Journal of Biodiversity Science, Ecosystem Services & Management 11(4) 330-340
    DOI: 10.1080/21513732.2015.1094515
  • Hermane J, Bułyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A (2015) New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90,  Chembiochem 16(2)302-311
    DOI: 10.1002/cbic.201402375
  • Karanja J, Poehling HM, Pallmann P (2015) Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter in the control of whiteflies Aleyrodes proletella and Trialeurodes vaporariorum (Hemiptera: Aleyrodidae),  Journal of Economic Entomology 108(3)1182–1190
    DOI: 10.1093/jee/tov047
  • Kitsche A, Schaarschmidt F (2015) Analysis of Statistical Interactions in Factorial Experiments,  Journal of Agronomy and Crop Science 201(1): 69-79.
    DOI: 10.1111/jac.12076
  • Konietschke F, Placzek M, Schaarschmidt F, Hothorn LA (2015) nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals,  Journal of Statistical Software 64(9)
    DOI: 10.18637/jss.v064.i09
  • Matthies S, Rüter S, Prasse R, Schaarschmidt F (2015) Factors driving the vascular plant species richness in urban green spaces: Using a multivariable approach,  Landscape and Urban Planning
    DOI: 10.1016/j.landurbplan.2014.10.014
  • Pallmann P, Hothorn LA (2015) Boxplots for grouped and clustered data in toxicology,  Arch Tox
    DOI: 10.1007/s00204-015-1608-4
  • Radespiel U, Schaber K, Kessler SE, Schaarschmidt F, Strube C (2015) Variations in the excretion patterns of helminth eggs in two sympatric mouse lemur species (Microcebus murinus and M. ravelobensis) in northwestern Madagascar,  Parasitology Research 114 (3): 941-954
    DOI: 10.1007/s00436-014-4259-0
  • Schaarschmidt F (2015) Confidence Intervals for the Risk Ratio when Analyzing Bioassays in the Presence of Overdispersion,  Biometrics and Biostatistics International Journal 2015, 2(7)
    DOI: 10.15406/bbij.2015.02.00050
  • Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA (2015) Statistical approaches for the determination of cut points in anti-drug antibody bioassays,  Journal of Immunological Methods 418, 84–100
    DOI: 10.1016/j.jim.2015.02.004
  • Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA (2015) Statistical approaches for the determination of cut points in anti-drug antibody bioassays,  Journal of Immunological Methods
    DOI: 10.1186/s12968-015-0177-2
  • Schomaker M, Killian D, Willenbrock S, Heinemann D, Kalies S, Ngezahayo A, Nolte I, Ripken T, Junghanß C, Meyer H, Murua Escobar H, Heisterkamp A (2015) Biophysical effects in off-resonant gold nanoparticle mediated (GNOME) laser transfection of cell lines, primary- and stem cells using fs laser pulses,  J Biophotonics 8(8):646-658
    DOI: 10.1002/jbio.201400065
  • Weese A, Pallmann P, Papenbrock J, Riemenschneider A (2015) Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack,  Frontiers in Plant Science, 6:9
    DOI: 10.3389/fpls.2015.00009
  • Wimalasekera R, Schaarschmidt F, Angelini R, Cona A, Tavladoraki P, Scherer GFE (2015) POLYAMINE OXIDASE2 of Arabidopsis Contributes to ABA Mediated Plant Developmental Processes,  Plant Physiology and Biochemistry 96:231-240
    DOI: 10.1016/j.plaphy.2015.08.003
  • Bohne H, Wanjiku J, Rathke A-K, Humpert S, Gerhard D (2014) Influence of Nutrient Loading on Growth, N-, P-, and K-Concentrations and Outplanting Performance of Rosa majalis,  European Journal of Horticultural Science 79(1):29-35
    ISBN: ISSN 1611-4426
  • Gerhard D (2014) Simultaneous Small Sample Inference For Linear Combinations Of Generalized Linear Model Parameters,  Communications in Statistics - Simulation and Computation 45(8)2678-2690
    DOI: 10.1080/03610918.2014.895836
  • Gerhard D, Bremer M, Ritz C (2014) Estimating marginal properties of quantitative real-time PCR data using nonlinear mixed models,  Biometrics 70(1):247-254
    DOI: 10.1111/biom.12124
  • Graf N, Dinkel B, Rose H, Hothorn LA, Gerhard D, Johansen P, Kundig TM, Klimek L, Senti G (2014) A critical appraisal of analyzing nasal provocation test results in allergen immunotherapy trials,  Rhinology 52(2):137-141
    DOI: 10.4193/Rhin
  • Hothorn LA (2014) Statistical evaluation of toxicological bioassays –a review,  Toxicology Research 3:418-432
    DOI: 10.1039/c4tx00047a
  • Jaki Th, Kitsche A, Hothorn LA (2014) Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group,  JP Journal of Biostatistics 11(1):1-32
  • Kitsche A (2014) Detecting qualitative interactions in clinical trials with binary responses,  Pharmaceutical Statistics 13(5): 309-315
    DOI: 10.1002/pst.1632
  • Kitsche A, Hothorn LA (2014) Testing for qualitative interaction using ratios of treatment differences,  Statistics in Medicine 33(9):1477-1489
    DOI: 10.1002/sim.6048
  • Kniggendorf AK, Meinhardt-Wollweber M, Yuan X, Roth B, Seifert A, Fertig N, Zeilinger C (2014) Temperature-sensitive gating of hCx26: high-resolution Raman spectroscopy sheds light on conformational changes,  Biomed Opt Express 5(7)2054-2065
    DOI: 10.1364/BOE.5.002054
  • Kuiper RM, Gerhard D, Hothorn LA (2014) Identification of the Minimum Effective Dose for Normally Distributed Endpoints Using a Model Selection Approach,  Statistics in Biopharmaceutical Research 6(1):55-66
    DOI: 10.1080/10543406.2017.1295247
  • Lee-Thedieck C, Spatz JP (2014) Biophysical regulation of hematopoietic stem cells,  Biomat Sci 2(11)1548-1561
    DOI: 10.1039/C4BM00128A
  • Meyer W, Oberthuer A, Ngezahayo A, Neumann U, Jacob R (2014) Immunohistochemical demonstration of connexins in the developing feather follicle of the chicken,  Acta Histochem 116(4):639-645
    DOI: 10.1016/j.acthis.2013.11.016
  • Pallmann P (2014) Book review: Applied meta-analysis with R,  Journal of Applied Statistics 42(4): 914-919
    DOI: 10.1080/02664763.2014.989464
  • Pallmann P, Hothorn LA, Djira GD (2014) A Levene-type test of homogeneity of several variances against ordered alternatives,  Computational Statistics 29(6): 1593-1608
    DOI: 10.1007/s00180-014-0508-z
  • Raic A, Röding L, Kalbacher H, Lee-Thedieck C (2014) Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells,  Biomat 35(3)929-940
    DOI: 10.1016/j.biomaterials.2013.10.038
  • Rödling L, Raic A, Lee-Thedieck C (2014) Fabrication of biofunctionalized, cell-laden macroporous 3D PEG hydrogels as bone marrow analogs for the cultivation of human hematopoietic stem and progenitor cells,  Biomimet a Stem Cells, 121-130
    DOI: 10.1007/7651_2014_84
  • Schaarschmidt F, Hothorn LA (2014) Statistical Methods and Software for Validation Studies on New In Vitro Toxicity Assays,  ATLA 42:319-329
  • Schax E, Walter JG, Märzhäuser H, Stahl F, Scheper T, Agard DA, Eichner S, Kirschning A, Zeilinger C (2014) Microarray-based screening of heat shock protein inhibitors,  J Biotechnol 180:1-9
    DOI: 10.1016/j.jbiotec.2014.03.006
  • Wagner S, Ngezahayo A, Murua Escobar H, Nolte I (2014) Role of miRNA let-7 and its major targets in prostate cancer,  Biomed Res Int 2014:376326
    DOI: 10.1155/2014/376326
  • Begandt D, Bader A, Dreyer L, Eisert N, Reeck T, Ngezahayo A (2013) Biphasic increase of gap junction coupling induced by dipyridamole in the rat aortic A-10 vascular smooth muscle cell line,  J Cell Comm Signal 7:151-160
    DOI: 10.1007/s12079-013-0196-4
  • Begandt D, Bader A, Gerhard L, Lindner J, Dreyer L, Sclingmann B, Ngezahayo A (2013) Dipyridamole-related enhancement of gap junction coupling in the GM-7373 aortic endothelial cells correlates with an increase in the amount of connexin 43 mRNA and protein as well as gap junction plaques,  J Bioenerg Biomembr 45:409-419
    DOI: 10.1007/s10863-013-9518-8
  • Hasler M, Hothorn LA (2013) Simultaneous confidence intervals on multivariate non-inferiority,  Statistics in Medicine, 32(10) 1720-1729
    DOI: 10.1002/sim.5633
  • Herberich E, Hothorn LA (2013) A Maximum-Type Association Test for Censored Time-to-Event Data,  Journal of Biometrics & Biostatistics, 4: 178
    DOI: 10.4172/2155-6180.1000178
  • Hothorn LA, Reisinger K, Wolf T, Poth A, Fieblinger D, Liebsch M, Pirow R (2013) Statistical analysis of the hens egg test for micronucleus induction (HET-MN Assay),  Mutation Research, 757(1)68-78
    DOI: 10.1016/j.mrgentox.2013.04.023
  • Jaki T, Hothorn LA (2013) Statistical evaluation of toxicological assays: Dunnett or Williams test- take both,  Archives of Toxicology, 87:1901-1910
    DOI: 10.1007/s00204-013-1065-x
  • Jaki T, Pallmann P, Wolfsegger MJ (2013) Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs,  Statistics in Medicine 32(30): 5469-5483
    DOI: 10.1002/sim.5886
  • Jaki T, Pallmann P, Wolfsegger MJ (2013) Authors' reply to Comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs",  Statistics in Medicine 32(30): 5487-5488
    DOI: 10.1002/sim.6000
  • Kitsche A, Kalesse M (2013) Configurational Assignment of Secondary Hydroxyl Groups and Methyl Branches in Polyketide Natural Products through Bioinformatic Analysis of the Ketoreductase Domain,  ChemBioChem 14(7):851-61
    DOI: 10.1002/cbic.201300063
  • Konietschke F, Bösiger S, Brunner E, Hothorn LA (2013) Are Multiple Contrasts Tests superior to the ANOVA?,  International Journal of Biostatistics
    DOI: 10.1515/ijb-2012-0020
  • Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn LA, Bremer S, van Thriel C, Krause K-H, Hengstler JG, Rahnenführer J (2013) Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach,  Archives of Toxicology 87(1):123-143
    DOI: 10.1007/s00204-012-0967-3
  • Loley C, König I, Hothorn LA, Ziegler A (2013) A unifying framework for robust association testing, estimation and genetic model selection using the generalized linear model,  European Journal of Human Genetics 21, 12; 1442-1448
    DOI: 10.1038/ejhg.2013.62
  • Maurer W, Bretz F (2013) Memory and other properties of multiple test procedures generated by entangled graphs,  Statistics in Medicine V32(10)1739-1753
    DOI: 10.1002/sim.5711
  • Moulay M, Liu W, Willenbrock S, Sterenczak KA, Carlson R, Ngezahayo A, Murua Escobar H, Nolte I (2013) Evaluation of stem cell marker gene expression in canine prostate carcinoma- and prostate cyst-derived cell lines,  Anticancer Res 33(12):5421-5431
  • Muth CA, Steinl G, Klein G, Lee-Thedieck C (2013) Regulation of hematopoietic stem cell behavior by the nanostructured presentation of extracellular matrix components,  PloS one 8(2)e54778
    DOI: 10.1371/journal.pone.0054778
  • Platzman I, Muth CA, Lee-Thedieck C, Pallarola D, Atanasova R, Louban I, Altrock E, Spatz JP (2013) Surface properties of nanostructured bio-active interfaces: impacts of surface stiffness and topography on cell–surface interactions,  Rsc Adv 3(32)13293-13303
    DOI: 10.1039/C3RA41579A
  • Priesnitz K-U, Benker U, Schaarschmidt F (2013) Assessment of the potential impact of a Bt maize hybrid expressing Cry3Bb1 on ground beetles (Carabidae),  Journal of Plant Diseases and Protection 120 (3), 131–140
    DOI: 10.1007/BF03356464
  • Ritz C, Gerhard D, Hothorn LA (2013) A unified framework for benchmark dose estimation applied to mixed models and model averaging,  Statistics in Biopharmaceutical Research 5(1):79-90
    DOI: 10.1080/19466315.2012.757559
  • Schaarschmidt, F. (2013) Simultaneous confidence intervals for multiple comparisons among expected values of log-normal variables,  Computational Statistics and Data Analysis 58, 265–275.
    DOI: 10.1016/j.csda.2012.08.011
  • Scherer R, Schaarschmidt F, Prescher S, Priesnitz KU (2013) Simultaneous confidence intervals for comparing biodiversity indices estimated from overdispersed count data,  Biometrical Journal 55 (2), 246–263
    DOI: 10.1002/bimj.201200157
  • Schlie-Wolter S, Ngezahayo A, Chichkov BN (2013) The selective role of ECM components on cell adhesion, morphology, proliferation and communication in vitro,  Exp Cell Res 319:1553-1561
    DOI: 10.1016/j.yexcr.2013.03.016
  • Schlingmann B, Schadzek P, Hemmerling F, Schaarschmidt F, Heisterkamp A, Ngezahayo A (2013) The role of the C-terminus in functional expression and internalization of rat connexin46 (rCx46),  J Bioenerg Biomembr 45:59-70
    DOI: 10.1007/s10863-012-9480-x
  • Altrock E, Muth CA, Klein G, Spatz JP, Lee-Thedieck C (2012) The significance of integrin ligand nanopatterning on lipid raft clustering in hematopoietic stem cells,  Biomat 33 (11)3107-3118
    DOI: 10.1016/j.biomaterials.2012.01.002
  • Bintig W, Begandt D, Schlingmann B, Gerhard L, Pangalos M, Dreyer L, Hohnjec N, Couraud PO, Romero IA, Weksler BB, Ngezahayo A (2012) Purine receptors and Ca2+ signalling in the human blood–brain barrier endothelial cell line hCMEC/D3,  Purinergic Signal 8(1):71–80
    DOI: 10.1007/s11302-011-9262-7
  • Bohne H, Kluge K, Amha Y, Gerhard D (2012) Influence of peats of different origins and decomposition degree on germination and early growth of Chinese cabbage,  European Journal of Horticultural Science 77(5):211-218
  • Hasler M, Hothorn LA (2012) A multivariate Williams-type trend procedure,  Statistics in Biopharmaceutical Research 4:57-65
    DOI: 10.1080/19466315.2011.633868
  • Herberich E, Hothorn LA (2012) Statistical evaluation of mortality in long-term carcinogenicity bioassays using a Williams-type procedure,  Regulatory Toxicology and Pharmacology 64(1):26-34
    DOI: 10.1016/j.yrtph.2012.06.014
  • Hoffmann S, Hothorn LA, Edler L, Kleensang A, Suzuki M, Phrakonkham P, Gerhard D (2012) Two new approaches to improve the analysis of BALB/c 3T3 cell transformation assay data,  Mutation Research - Genetic Toxicology and Environmental Mutagenesis 744(1):36-41
    DOI: 10.1016/j.mrgentox.2011.12.002
  • Hothorn LA, Libiger O, Gerhard D (2012) Model-specific tests on variance heterogeneity for detection of potentially interacting genetic loci,  BMC Genetics 13:59
    DOI: 10.1186/1471-2156-13-59
  • Kitsche A, Schaarschmidt F, Hothorn LA (2012) The use of historical controls in estimation of simultaneous confidence intervals for comparisons against a concurrent control,  Computational Statistics and Data Analysis 56(12):3865-3875
    DOI: 10.1016/j.csda.2012.05.010
  • Konietschke F, Hothorn LA (2012) Evaluation of toxicological studies using a non-parametric Shirley-type trend test for comparing several dose levels with a control group,  Statistics in Biopharmaceutical Research 4:14-27
    DOI: 10.1080/19466315.2011.633861
  • Konietschke F, Hothorn LA, Brunner E (2012) Rank-based multiple test procedures and simultaneous confidence intervals,  Electronic Journal of Statistics 6:737-759
    DOI: 10.1214/12-EJS691
  • Konietschke F, Libiger O, Hothorn LA (2012) Nonparametric Evaluation of Quantitative Traits in Population-Based Association Studies when the Genetic Model is Unknown,  PLoS ONE 7(2):e31242
    DOI: 10.1371/journal.pone.0031242
  • Lee-Thedieck C, Rauch N, Fiammengo R, Klein G, Spatz JP (2012) Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility,  J Cell Sci 125(16)3765-3775
    DOI: 10.1242/jcs.095596
  • Lee‐Thedieck C, Spatz JP (2012) Macromol. Rapid Commun. 17/2012,  Macromol Rap Comm 17(33)1496-1496
    DOI: 10.1002/marc.201290060
  • Lee‐Thedieck C, Spatz JP (2012) Artificial niches: biomimetic materials for hematopoietic stem cell culture,  Macromol rapid comm 33(17)1432-1438
    DOI: 10.1002/marc.201200219
  • Pallmann P, Schaarschmidt F, Hothorn LA, Fischer C, Nacke H, Priesnitz KU, Schork NJ (2012) Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indices,  Molecular Ecology Resources 12(6): 1068-1078
    DOI: 10.1111/1755-0998.12004
  • Schlingmann B, Schadzek P, Busko S, Heisterkamp A, Ngezahayo A (2012) Cataract-associated D3Y mutation of human connexin46 (hCx46) increases the dye coupling of gap junction channels and suppresses the voltage sensitivity of hemichannels,  J Bioenerg Biomembr 44:607-614
    DOI: 10.1007/s10863-012-9461-0
  • Schüler Y, Lee‐Thedieck C, Geiger K, Kaiser T, Ino Y, Aicher WK, Klein G (2012) Osteoblast‐secreted factors enhance the expression of dysadherin and CCL2‐dependent migration of renal carcinoma cells,  Int J Cancer 130(2)288-299
    DOI: 10.1002/ijc.25981
  • Senti G, Crameri R, Kuster D, Johansen P, Martinez-Gomez JM, Graf N, Steiner M, Hothorn LA, Grönlund H, Tivig C, Zaleska A, Soyer O, van Hage M, Akdis CA, Akdis M, Rose H, Kündig TM (2012) Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections,  Journal of Allergy and Clinical Immunology 129(5):1290-1296
    DOI: 10.1016/j.jaci.2012.02.026
  • Strohmaier J, Amelang M, Hothorn LA, Witt SH, Nieratschker V, Gerhard D, Meier S, Wüst S, Frank J, Loerbroks A, Rietschel M, Stürmer T, Schulze TG (2012) The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population,  Molecular Psychatry 18(5):607-613
    DOI: 10.1038/mp.2012.53
  • Altrock E, Lee-Thedieck C, Klein G, Spatz J (2011) Lipid raft formation of hematopoietic stem cells in response to nano-patterned substrates,  TISSUE ENGINEERING PART A 17(3-4)572-572
    DOI: 10.1089/ten.tea.2010.1502
  • Bohne H, Salomon L, Gerhard D (2011) Influence of provenance and fertilization in the tree nursery on outplanting performance and N-, P-, and K-content of Viburnum opulus L. in shoots and roots,  Journal of Environmental Horticulture 29(3):137-142
    DOI: 10.24266/0738-2898-29.3.137
  • Bunck AC, Kröger J-R, Juettner A, Brentrup A, Fiedler B, Schaarschmidt F, Crelier G, Schwindt W, Heindel W, Niederstadt T, Maintz D (2011) Magnetic resonance 4D flow characteristics of cerebrospinal fluid at the craniocervical junction and the cervical spinal canal,  European Radiology 21(8)1788–1796
    DOI: 10.1007/s00330-011-2105-7
  • Dreyer L, Krolitzki B, Autschbach R, Vogt P, Welte T, Ngezahayo A, Glasmacher B (2011) An Advanced Cone-And-Plate Reactor for the in vitro-Application of Shear Stress on Adherent Cells,  Clin Hemorheol Microcirc 49(1-4)391-397
    DOI: 10.3233/CH-2011-1488
  • Hasler M, Hothorn LA (2011) A Dunnett-Type Procedure for Multiple Endpoints,  The International Journal of Biostatistics 7(1):3-3
    DOI: 10.2202/1557-4679.1258
  • Hirotsu C, Yamamoto S, Hothorn LA (2011) Estimating the Dose-Response Pattern by the Maximal Contrast Type Test Approach,  Statistics in Biopharmaceutical Research 3(1)40-53
    DOI: 10.1198/sbr.2010.08093
  • Hothorn LA, Djira GD (2011) A ratio-to-control Williams-type test for trend,  Pharmaceutical Statistics 10(4):289-292
    DOI: 10.1002/pst.464
  • Lee-Thedieck C, Rauch N, Fiammengo R, Klein G, Spatz J (2011) Regulation of Hematopoietic Stem Cell Behaviour by Matrix Elasticity,  TISSUE ENGINEERING PART A 17(3-4)539-540
    DOI: 10.1089/ten.tea.2010.1502
  • Lee-thedieck C, Rauch N, Fiammengo R, Klein G, Spatz JP (2011) substrate elasticity controls hematopoietic stem cell adhesion and migration: op-067,  Regenerat Med 6(6)104
    ISBN: ISSN: 1746-0751
  • Muth C, Lee-Thedieck C, Steinl C, Klein G, Spatz J (2011) Towards an Artificial Stem Cell Niche: Interaction analysis of hematopoietic stem cells with nanostructured, biofunctionalized surfaces,  TISSUE ENGINEERING PART A 17(3-4)563-564
    DOI: 10.1089/ten.tea.2010.1502
  • Nerem RM, Winkler J, Cancedda R, Tasso R, Tortelli F, Mastrogiacomo M, ... (2011) Microscale culture of human liver cells for drug development,  Tissue Engineering Part A 17(3-4)531-584
    DOI: 10.1089/ten.tea.2010.1502
  • Pangalos M, Bintig W, Schlingmann B, Feyerabend F, Witte F, Begandt D, Heisterkamp A, Ngezahayo A (2011) Action potentials in primary osteoblasts and in the MG-63 osteoblast-like cell line,  J Bioenerg Biomembr 43(3)311–322
    DOI: 10.1007/s10863-011-9354-7
  • Selig M, Bohne H, Gerhard D (2011) Influence of refertilization of Salix cinerea L. in late summer on early frost hardiness and on some nutrients and biomarker,  Gesunde Pflanzen 63(3):129-133
    DOI: 10.1007/s10343-011-0256-8
  • Baumgart J, Bintig W, Ngezahayo A, Lubatschowski H, Heisterkamp A (2010) Fs-laser-induced Ca2+ concentration change during membrane perforation for cell transfection,  Opt Express 18:2219-2229
    DOI: 10.1364/OE.18.002219
  • Begandt D, Bintig W, Oberheide K, Schlie S, Ngezahayo A (2010) Dipyridamole increases gap junction coupling in bovine GM-7373 aortic endothelial cells by a cAMP-protein kinase A dependent pathway,  J Bioenerg Biomembr 42(1)79-84
    DOI: 10.1007/s10863-009-9262-2
  • Bilder CR, Zhang B, Schaarschmidt F, Tebbs JM (2010) binGroup: A Package for Group Testing,  The R Journal 2/2, 56-60
  • Djira GD, Schaarschmidt F, Fayissa B (2010) Inferences for Selected Location Quotients with Applications to Health Outcomes,  Geographical Analysis 42(3)288-300
    DOI: 10.1111/j.1538-4632.2010.00794.x
  • Gerhard D, Hothorn LA (2010) Rank transformation in Haseman-Elston regression using scores for location-scale alternatives,  Human Heredity 69(3):143-151
    DOI: 10.1159/000267994
  • Hothorn LA, Sill M, Schaarschmidt F (2010) Evaluation of Incidence Rates in Pre-Clinical Studies Using a Williams-Type Procedure,  The International Journal of Biostatistics 6(1):15
    DOI: 10.2202/1557-4679.1180
  • Hothorn LA, Vohr HW (2010) Statistical Evaluation of the Local Lymph Node Assay,  Regulatory Toxicology and Pharmacology 56(3):352-356
    DOI: 10.1016/j.yrtph.2009.10.007
  • Konietschke F, Bathke AC, Hothorn LA, Brunner E (2010) Testing and estimation of purely nonparametric effects in repeated measures designs,  Computational Statistics and Data Analysis 54:1895-1905
    DOI: 10.1016/j.csda.2010.02.019
  • Menke S, Gerhard D (2010) Detection of a related difference in efficacy of azadirachtin treatments for the control of whiteflies on Gerbera jamesonii by testing for interactions in generalised linear models,  Pest Management Science 66(4):358-364
    DOI: 10.1002/ps.1881
  • Rauschen S, Schaarschmidt F, Gathmann A (2010) Occurrence and field densities of Coleoptera in the maize herb layer: implications for Environmental Risk Assessment of genetically modified Bt-maize,  Transgenic Research 19:727-744
    DOI: 10.1007/s11248-009-9351-3
  • Rauschen S, Schultheis E, Hunfeld H, Schaarschmidt F, Schuphan I, Eber S (2010) Diabrotica-resistant Bt-maize DKc5143 event MON88017 has no impact on the field densities of the leafhopper Zyginidia scutellaris,  Environmental Biosafety Research 9, 87–99
    DOI: 10.1051/ebr/2010012
  • Schlie S, Fadeeva E, Koch J, Ngezahayo A, Chichkov BN (2010) Femtosecond laser fabricated spike structures for selective control of cellular behavior,  J Biomat App 25(3)217-233
    DOI: 10.1177/0885328209345553
  • Schomaker M, Killian D, Willenbrock S, Diebold E, Mazur E, Bintig W, Ngezahayo A, Nolte I, Escobar HM, Junghanß C, Lubatschowski H, Heisterkamp A (2010) Ultrashort laser pulse cell manipulation using nano- and micro- materials,  Proc SPIE 7762
    DOI: 10.1117/12.869054
  • Zimmermann H, Gerhard D, Dingermann T, Hothorn LA (2010) Statistical aspects of design and validation of microtitre-plate-based linear and non-linear parallel in vitro bioassays,  Biotechnology Journal 5(1):62-74
    DOI: 10.1002/biot.200900146
  • Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010) An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 1,  Pharmazeutische Industrie 72(4):708-712
  • Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010) An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 2,  Pharmazeutische Industrie 72(5):884-895
  • Acutis M, Hothorn LA, McNicol J, van der Voet H (2009) Statistical considerations for the safety evaluation of GMOs,  EFSA Journal 1250:1
    DOI: 10.2903/j.efsa.2010.1250
  • Baumgart J, Kuetemeyer K, Bintig W, Ngezahayo A, Ertmer W, Lubatschowski H, Heisterkamp A (2009) Repetition rate dependency of reactive oxygen species formation during femtosecond laser-based cell surgery,  J Biomed Opt 14(5):054040
    DOI: 10.1117/1.3253382
  • Bintig W, Baumgart J, Walter WJ, Heisterkamp A, Lubatschowski H, Ngezahayo A (2009) Purinergic signalling in rat GFSHR-17 granulosa cells: an in vitro model of granulosa cells in maturing follicles,  J Bioenerg Biomembr 41:85-94
    DOI: 10.1007/s10863-009-9199-5
  • Djira GD, Hothorn LA (2009) Detecting Relative Changes in Multiple Comparisons with an Overall Mean,  Journal of Quality Technology 41(1):60-65
    DOI: 10.1080/00224065.2009.11917760
  • Hothorn LA, Gerhard D (2009) Statistical evaluation of the in vivo micronucleus assay,  Archives of Toxicology 83(6):625-634
    DOI: 10.1007/s00204-008-0393-8
  • Hothorn LA, Gerhard D, Hofmann M (2009) Parametric and non-parametric prediction intervals based phase II control charts for repeated bioassay data,  Biologicals 37(5): 323-330
    DOI: 10.1016/j.biologicals.2009.07.001
  • Hothorn LA, Hothorn T (2009) Order-restricted Scores Test for the Evaluation of Population based Case–control Studies when the Genetic Model is Unknown,  Biometrical Journal 51(4):659-669
    DOI: 10.1002/bimj.200800203
  • Hothorn LA, Vaeth M, Hothorn T (2009) Trend tests for the evaluation of exposure-response relationships in epidemiological exposure studies,  Epidemiologic Perspectives & Innovations 6:1
    DOI: 10.1186/1742-5573-6-1
  • Perry JN, ter Braak CJF, Dixon PM, Duan JJ, Hails RS, Huesken A, Lavielle M, Marvier M, Scardi M, Schmidt K, Tothmeresz B, Schaarschmidt F, van der Voet H (2009) Statistical aspects of environmental risk assessment of GM plants for effects on non-target organisms,  Environmental Biosafety Research 8:65-78
    DOI: 10.1051/ebr/2009009
  • Schaarschmidt F, Biesheuvel E, Hothorn LA (2009) Asymptotic Simultaneous Confidence Intervals for Many-to-One Comparisons of Binary Proportions in Randomized Clinical Trials,  Journal of Biopharmaceutical Statistics 19:292-310
    DOI: 10.1080/10543400802622501
  • Schaarschmidt F, Vaas L (2009) Analysis of trials with complex treatment structure using multiple contrast tests,  HortScience 44(1):188-195
    DOI: 10.21273/HORTSCI.44.1.188
  • Schueler Y, Thedieck C, Klein G (2009) Interactions of renal carcinoma cells with the microenvironment of the human bone marrow,  CLIN & EXP METASTAS 26(7)922-922
  • Thedieck C, Sonntag C, Rauch N, Fiammengo R, Martin R, Klein G, ... (2009) Towards an Artificial Stem Cell Niche: Impact of Biofunctionalized Nanopatterns and Matrix Stiffness on Hematopoietic Stem Cells,  TISSUE ENGINEERING PART A 15(3)684-684
    DOI: 10.1089/ten.tea.2009.1500
  • Baumgart J, Bintig W, Ngezahayo A, Willenbrock S, Murua Escobar H, Ertmer W, Lubatschowski H, Heisterkamp A (2008) Quantified femtosecond laser based opto-perforation of living GFSHR-17 and MTH53 a cells,  Opt Expr 16:3021-3031
    DOI: 10.1364/OE.16.003021
  • Braat S, Gerhard D, Hothorn LA (2008) Joint one-sided and two-sided simultaneous confidence intervals,  Journal of Biopharmaceutical Statistics. 18(2):293-306
    DOI: 10.1080/10543400701697174
  • Dilba G, Hothorn LA, Tsong Y (2008) Equivalence Tests for Shelf Life and Average Drug Content in Stability Studies,  Journal of Biopharmaceutical Statistics 18(5):985-995
    DOI: 10.1080/10543400802287230
  • Fadeeva E, Schlie S, Koch J, Ngezahayo A, Chichkov BN (2008) The hydrophobic properties of femtosecond laser fabricated spike structures and their effects on cell proliferation,  Physica Status Solidi
    DOI: 10.1002/pssa.200881063
  • Froemke C, Hothorn LA, Kropf S (2008) Nonparametric relevance-shifted multiple testing procedures for the analysis of high-dimensional multivariate data with small sample sizes,  BMC Bioinformatics 9:54
    DOI: 10.1186/1471-2105-9-54
  • Hasler M, Hothorn LA (2008) Multiple Contrast Tests in the Presence of Heteroscedasticity,  Biometrical Journal 50(5)793-800
    DOI: 10.1002/bimj.200710466
  • Hasler M, Vonk R, Hothorn LA (2008) Assessing non-inferiority of a new treatment in a three-arm trial in the presence of heteroscedasticity,  Statistics in Medicine 27:490-503
    DOI: 10.1002/sim.3052
  • Hothorn LA, Hasler M (2008) Proof of hazard and proof of safety in toxicological studies using simultaneous confidence intervals for differences and ratios to control,  Journal of Biopharmaceutical Statistics 18(5)915-933
    DOI: 10.1080/10543400802287511
  • Hughes S (2008) European regulatory agencies should employ full time statisticians,  British Medical Journal 336(7638):250
    DOI: 10.1136/bmj.39470.632951.59
  • Rauschen S, Eckert J, Schaarschmidt F, Schuphan I, Gathmann A (2008) An evaluation of methods for assessing the impacts of Bt-maize MON810 cultivation and pyrethroid insecticide use on Auchenorrhyncha (Planthoppers and Leafhoppers),  Agricultural and Forest Entomology 10(4)331-339
    DOI: 10.1111/j.1461-9563.2008.00394.x
  • Schaarschmidt F, Sill M, Hothorn LA (2008) Approximate Simultaneous Confidence Intervals for Multiple Contrasts of Binomial Proportions,  Biometrical Journal 50(5)782-792
    DOI: 10.1002/bimj.200710465
  • Schaarschmidt F, Sill M, Hothorn LA (2008) Poly-k-trend tests for survival adjusted analysis of tumor rates formulated as approximate multiple contrast test,  Journal of Biopharmaceutical Statistics 18(5)934-948
    DOI: 10.1080/10543400802294285
  • Schueler Y, Kaiser T, Thedieck C, Fehm T, Klein G (2008) P27. Molecular interactions of disseminated tumor cells with the microenvironment of the bone marrow,  Cancer Treatm Rev 34:23
    DOI: 10.1016/j.ctrv.2008.03.069
  • Schunkert H, Götz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Linsel-Nitschke P, Cambien F, Hengstenberg C, Stark K, Blankenberg S, Tiret L, Ducimetiere P, Keniry A, Ghori MJ, Schreiber S, El Mokhtari NE, Hall AS, Dixon RJ, Goodall AH, Liptau H, Pollard H, Schwarz DF, Hothorn LA, Wichmann HE, König IR, Fischer M, Meisinger C, Ouwehand W, Deloukas P, Thompson JR, Erdmann J, Ziegler A, Samani NJ; Cardiogenics Consortium (2008) Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease,  Circulation 117(13):1675-1684
    DOI: 10.1161/CIRCULATIONAHA.107.730614 PMCID: PMC2689930 EMSID: UKMS4596
  • Steffens M, Göpel F, Ngezahayo A, Zeilinger C, Ernst A, Kolb H-A (2008) Regulation of connexons composed of human connexin26 (hCx26) by temperature,  Biochem Biophys Acta 1778:1206-1212
    DOI: 10.1016/j.bbamem.2008.01.016
  • Thedieck C, Kalbacher H, Kratzer U, Lammers R, Stevanovic S, Klein G (2008) αB-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16,  J mol bio 378(1)145-153
    DOI: 10.1016/j.jmb.2008.02.008
  • Walter WJ, Zeilinger C, Bintig W, Kolb H-A, Ngezahayo A (2008) Phosphorylation in the C-terminus of the rat connexin46 (rCx46) and regulation of the conducting activity of the formed connexons,  J Bioenerg Biomembr 40:397-405
    DOI: 10.1007/s10863-008-9151-0
  • Dilba G, Schaarschmidt F, Hothorn LA (2007) Inferences for ratios of normal means,  R News 7(1):20-23
  • Heisterkamp A, Baumgart J, Maxwell IZ, Ngezahayo A, E Mazur E, Lubatschowski H (2007) Fs-laser scissors for photobleaching, ablation in fixed samples and living cells, and studies of cell mechanics,  Meth Cell Biol 82,293-307
    DOI: 10.1016/S0091-679X(06)82009-1
  • Hothorn LA (2007) How to deal with multiple treatment or dose groups in randomized clinical trials?,  Fundamental & Clinical Pharmacology 21(2):137-154
    DOI: 10.1111/j.1472-8206.2007.00469.x
  • Ovsianikov A, Schlie S, Ngezahayo A, Haverich A, Chichkov BN (2007) Two-photon polymerization technique for microfabrication of CAD-designed 3D scaffolds from commercially available photosensitive materials,  J Tissue Eng Regen Med 1(6):443-449
    DOI: 10.1002/term.57
  • Pätzold R, Keuntje M, Theophile K, Müller J, Mielcarek E, Ngezahayo A, Anders-von Ahlften A (2007) In situ mapping of nitrifiers and anammox bacteria in microbial aggregates by means of confocal resonance Raman microscopy,  J Microb Meth 72(3)241-248
    DOI: 10.1016/j.mimet.2007.12.003
  • Schaarschmidt F (2007) Experimental design for one-sided confidence intervals or hypothesis tests in binomial group testing,  Communications in Biometry and Crop Science 2(1):32-40
  • Schlie S, Ngezahayo A, Ovsianikov A, Fabian T, Kolb H-A, Haferkamp H, Chichkov BN (2007) Three-dimensional cell growth on structures fabricated from ORMOCER® by two-photon polymerisation technique,  J Biomater Applic 22(3)275-287
    DOI: 10.1177/0885328207077590
  • Thedieck C, Kalbacher H, Kuczyk M, Müller GA, Müller CA, Klein G (2007) Cadherin-9 is a novel cell surface marker for the heterogeneous pool of renal fibroblasts,  PLoS One 2(8)e657
    DOI: 10.1371/journal.pone.0000657
  • Toschki A, Hothorn LA, Ross-Nickoll M (2007) Effects of cultivation of genetically modified Bt maize on epigeic arthropods,  Environmental Entomology 36(4):967-981
    DOI: 10.1603/0046-225X(2007)36[967:EOCOGM]2.0.CO;2
  • Baumgart J, Heisterkamp A, Ngezahayo A, Ertmer W, Lubatschowski H (2006) Cell surgery by fs-laser pulses,  Proc SPIE, Commercial and Biomedical Applications of Ultrafast Lasers VII, 6108:271-279
  • Dilba G, Bretz F, Hothorn LA, Guiard V (2006) Power and sample size computations in simultaneous tests for non-inferiority based on relative margins,  Statistics in Medicine 25(7):1131-1147
    DOI: 10.1002/sim.2359
  • Eckert J, Schuphan L, Hothorn LA, Gathmann A (2006) Arthropods on Maize Ears for Detecting Impacts of Bt Maize on Nontarget Organisms,  Environmental Entomology 35:554-560
    DOI: 10.1603/0046-225X-35.2.554
  • Flad T, Mueller L, Dihazi H, Grigorova V, Bogumil R, Beck A, Thedieck C, Mueller GA, Kalbacher H, Mueller CA (2006) T cell epitope definition by differential mass spectrometry: Identification of a novel, immunogenic HLA‐B8 ligand directly from renal cancer tissue,  Proteomics 6(1)364-374
    DOI: 10.1002/pmic.200500099
  • Gathmann A, Wirooks L, Hothorn LA, Bartsch D, Schuphan I (2006) Impact of Bt maize pollen (MON810) on lepidopteran larvae living on accompanying weeds,  Molecular Ecology 15(9):2677-2685
    DOI: 10.1111/j.1365-294X.2006.02962.x
  • Hauschke D, Hothorn LA (2006) Letter to Editor: An introductory note to the CHMP guidelines: choice of the non-inferiority margin and data monitoring committees by David Brown, Peter Volkers and Simon Day,  Statistics in Medicine 25:1623-1627; Statistics in Medicine 26:230-236
    DOI: 10.1002/sim.2665
  • Hothorn LA (2006) Multiple comparisons and multiple contrasts in randomized dose-response trials - confidence interval orient approaches,  Journal of Biopharmaceutical Statistics 16(5)711-731
    DOI: 10.1080/10543400600860576
  • Hothorn LA (2006) Statistical analysis of in vivo anticancer experiments: Tumor growth inhibition,  Drug Information Journal 40:229-238
    DOI: 10.1177/009286150604000212
  • Hothorn LA, Bleiholder H (2006) Statistical aspects of efficacy evaluation of plant protection products in field trials – a comment on EPPO Standard PP1/152,  EPPO Bulletin 36:31-45
    DOI: 10.1111/j.1365-2338.2006.00934.x
  • Hothorn LA, Oberdörfer R (2006) Statistical analysis used in the nutritional assessment of novel food using the proof of safety,  Regulatory Toxicology and Pharmacology 44:125-135
    DOI: 10.1016/j.yrtph.2005.10.001
  • Kikuchi T, Zhao HB, Ngezahayo A, White TW (2006) Gap Junctions and Cochlear Homeostasis,  J Membr Biol 209:177-186
    DOI: 10.1007/s00232-005-0832-x
  • Neuhäuser M, Hothorn LA (2006) A robust modification of the ordered-heterogeneity test,  Journal of Applied Statistics 33(7)721-727
    DOI: 10.1080/02664760600708954
  • Thirion C, Lochmüller H, Ruzsics Z, Boelhauve M, König C, Thedieck C (2006) Adenovirus vectors based on human adenovirus type 19a have high potential for human muscle-directed gene therapy,  Human gene therapy 17(2)193-205
    DOI: 10.1089/hum.2006.17.193
  • Dette H, Trampisch M, Hothorn LA (2005) Robust Designs in Noninferiority Three-Arm Clinical Trials With Presence of Heteroscedasticity,  Statistics in Biopharmaceutical Research 1(3):268-278
    DOI: 10.1198/sbr.2009.0021
  • Hothorn LA (2005) Biostatistics in nonclinical and preclinical drug development,  Biometrical Journal 47(3)282-285
    DOI: 10.1002/bimj.200510128
  • Ngezahayo A, Altmann B, Steffens M, Kolb H-A (2005) Gap Junction Coupling and Apoptosis in GFSHR-17 Granulosa Cells,  J Membr Biol 204:137-144
    DOI: 10.1007/s00232-005-0756-5
  • Thedieck C, Kuczyk M, Klingel K, Steiert I, Müller CA, Klein G (2005) Expression of Ksp-cadherin during kidney development and in renal cell carcinoma,  Brit J Cancer 92
    DOI: 10.1038/sj.bjc.6602597
  • Breidert S, Jakob R, Ngezahayo A, Kolb H-A, Naim HY (2004) Trafficking pathways of Cx49-GFP in living mammalian cells,  Biol Chem 386:155-160
    DOI: 10.1515/BC.2005.019
  • Debarry M, Marten I, Ngezahayo A, Kolb H-A (2004) Differential defense responses in sweet potato suspension culture,  Plant Sci. 168:1171-1179
    DOI: 10.1016/j.plantsci.2004.12.016
  • Dilba G, Bretz F, Guiard V, Hothorn LA (2004) Simultaneous confidence intervals for ratios with application to the comparison of several treatments with a control,  Methods of Information in Medicine 43(5)465-469
    DOI: 10.1267/METH04050465
  • Enders O, Ngezahayo A, Wiechmann M, Leisten F, Kolb H-A (2004) Structural calorimetry of main transition of supported DMPC bilayers by temperature controlled AFM,  Biophys J 87:2522-2531
    DOI: 10.1529/biophysj.104.040105
  • Hothorn LA, Bauss F (2004) Biostatistical design and analyses of long-term animal studies simulating human postmenopausal osteoporosis,  Drug Information Journal 38(1)47-56
    DOI: 10.1177/009286150403800107
  • Neuhäuser M, Buening H, Hothorn LA (2004) Maximum test versus adaptive tests for the two-sample location problem,  Journal of Applied Statistics 31(2):215-227
    DOI: 10.1080/0266476032000148876
  • Biesheuvel E, Hothorn LA (2003) Protocol designed subgroup analyses in multiarmed clinical trials: multiplicity aspects,  Journal of Biopharmaceutical Statistics 13(4)663-673
    DOI: 10.1081/BIP-120024201
  • Blödow A, Ngezahayo A, Ernst A, Kolb H-A (2003) Calmodulin antagonists suppress gap junction coupling in isolated Hensen cells of the guinea pig cochlea,  Pflügers Arch 446:36-41
    DOI: 10.1007/s00424-002-1004-9
  • Bretz F, Hothorn LA (2003) Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assays,  ATLA: Alternatives to Lab Animals 31(1):81-96
  • Bretz F, Hothorn LA, Hsu J (2003) Identifying effective and/or safe doses by stepwise confidence intervals for ratios,  Statistics in Medicine 22(6)847-858
    DOI: 10.1002/sim.1449
  • Hauschke D, Hothorn LA (2003) Two-stage testing of safety: A statistical view,  ATLA: Alternatives to Lab Animals 31(1):77-80
  • Hirotsu C, Hothorn LA (2003) Impact of the ICH E9 guideline: statistical principles for clinical trials on the conduct of clinical trials in Japan,  Drug Information Journal 37(4)381-396
    DOI: 10.1177/009286150303700405
  • Hothorn LA (2003) Statistics of interlaboratory in vitro toxicological studies,  ATLA: Alternatives to Lab Animals 31(1):43-63
  • Hothorn LA, Bretz F (2003) Dose-response and thresholds in mutagenicity studies: A statistical testing approach,  ATLA: Alternatives to Lab Animals 31(1):97-103
  • Hothorn LA, Wassmer G (2003) Analyzing randomized dose finding studies with a primary and a secondary endpoint,  Journal of Biopharmaceutical Statistics 13(2)301-305
    DOI: 10.1081/BIP-120019273
  • Neuhäuser M, Leisler B, Hothorn LA (2003) A trend test for the analysis of multiple paternity,  Journal of Agricultural, Biological, and Environmental Statistics 8:29-35
    DOI: 10.1198/1085711031184
  • Ngezahayo A, Altmann B, Kolb H-A (2003) Regulation of gap junctional coupling, ion fluxes and cell volume by cGMP in GFSHR-17 granulosa cells,  J Membr Biol 194:165-176
    DOI: 10.1007/s00232-003-2033-9
  • Bauss F, Lalla S, Endele R, Hothorn LA (2002) Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats,  Journal of Rheumatology 29(10):2200-2208
  • Bauss F, Wagner M, Hothorn LA (2002) Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats,  Journal of Rheumatology 29(5)990-998
  • Biesheuvel E, Hothorn LA (2002) Many-to-one comparisons in stratified designs,  Biometrical Journal 44(1)101-116
    DOI: 10.1002/1521-4036(200201)44:13.0.CO;2-H
  • Bretz F, Hothorn LA (2002) Detecting dose–response using contrasts: asymptotic power and sample size determination for binomial data,  Statistics in Medicine 21(2)3325-3335
    DOI: 10.1002/sim.1324
  • Hothorn LA (2002) Selected biostatistical aspects of the validation of in vitro toxicological assays,  ATLA: Alternatives to Lab Animals 30(2):93-98
  • Schulte A, Althoff J, Ewe S, Richter-Reichhelm HB; BGVV Group Investigators (2002) Two immunotoxicity ring studies according to OECD TG 407-comparison of data on cyclosporin A and hexachlorobenzene,  Regulatory Toxicology and Pharmacology 36(1):12-21
    DOI: 10.1006/rtph.2002.1568
  • Weichert M, Hothorn LA (2002) Robust hybrid tests for the two-sample location problem,  Communications in Statistics - Simulation and Computation 31:175-187
    DOI: 10.1081/SAC-120003333
  • Bauer P, Hothorn LA, Westfall P (2001) Special issue multiple comparison procedures,  Biometrical Journal 43:531
  • Bretz F, Genz A, Hothorn LA (2001) On the numerical availibilty of multiple comparison procedures,  Biometrical Journal 43(5)645-656
    DOI: 10.1002/1521-4036(200109)43:5<645::AID-BIMJ645>3.0.CO;2-F
  • Bretz F, Hothorn LA (2001) Testing dose-response relationships with a priori unknown possibly nonmonotone shapes,  Journal of Biopharmaceutical Statistics 11(3)193-207
    DOI: 10.1081/BIP-100107657
  • Munzel U, Hothorn LA (2001) An unified approach to simultaneous rank test procedures in the unbalanced one-way layout,  Biometrical Journal 43(5)553-559
    DOI: 10.1002/1521-4036(200109)43:5<553::AID-BIMJ553>3.0.CO;2-N
  • Tamhane AC, Hothorn LA (2001) Letter to the editor: A multiple comparison procedure for the three and four-armed controlled clinical trials,  Statistics in Medicine 20(2)317-321
  • Todt I, Ngezahayo A, Ernst A, Kolb H-A (2001) Hydrogen peroxide inhibits gap junctional coupling and modulates intracellular free calcium in cochlear Hensen cells,  J Membr Biol 181:107-114
    DOI: 10.1007/s00232001-0014-4
  • Bretz F, Hothorn LA (2000) A powerful alternative to Williams' test with application to toxicological doseresponse relationships of normally distributed data,  Environmental and Ecological Statistics 7:135-154
    DOI: 10.1023/A:1009622928188
  • Hothorn LA, Bretz F (2000) One-sided simultaneous confidence intervals for effective dose steps in unbalanced designs,  Biometrical Journal 42:995-1006
    DOI: 10.1002/1521-4036(200012)42:8<995::AID-BIMJ995>3.0.CO;2-4
  • Hothorn LA, Bretz F (2000) Evaluation of animal carcinogenicity studies. Cochran-Armitage trend test vs. multiple contrast tests,  Biometrical Journal 42(5)553-567
    DOI: 10.1002/1521-4036(200009)42:5<553::AID-BIMJ553>3.0.CO;2-R
  • Hothorn LA, Hauschke D (2000) Identifying the maximum safe dose: a multiple testing approach,  Journal of Biopharmaceutical Statistics 10(1)15-30
    DOI: 10.1081/BIP-100101010
  • Hothorn LA, Hayashi M, Seidel D (2000) Dose-response relationships in mutagenicity assays including an appropriate positive control group: a multiple testing approach,  Environmental and Ecological Statistics 7:27-42
    DOI: 10.1023/A:1009654728475
  • Jedamzik B, Marten I, Ngezahayo A, Ernst A, Kolb H-A (2000) Regulation of Lens rCx46-formed Hemichannels by Activation of Protein Kinase C, External Ca2+ and Protons,  J Membr Biol 173:39-46
    DOI: 10.1007/s002320001005
  • Lehmacher W, Kieser M, Hothorn LA (2000) Sequential and multiple testing for dose-response analysis,  Drug Information Journal 34(2)591-597
    DOI: 10.1177/009286150003400227
  • Neuhäuser M, Hothorn LA (2000) Parametric location-scale and scale trend tests based on Levene’s transformation,  Computational Statistics and Data Analysis 33:189-200
    DOI: 10.1016/S0167-9473(99)00051-1
  • Neuhäuser M, Seidel D, Hothorn LA (2000) Robust trend tests with application to toxicology,  Environmental and Ecological Statistics 7:43-56
    DOI: 10.1023/A:1009606812545
  • Ngezahayo A, Schachner M, Artola A (2000) Synaptic activity modulates the induction of bidirectional synaptic changes in adult mouse hippocampus,  J Neurosci 20:2451-2458
    DOI: 10.1523/JNEUROSCI.20-07-02451.2000
  • Hauschke D, Kieser M, Hothorn LA (1999) Proof of safety in toxicology based on the ratio of two means for normally distributed data,  Biometrical Journal 41(3)295-304
    DOI: 10.1002/(SICI)1521-4036(199906)41:3<295::AID-BIMJ295>3.0.CO;2-2
  • Hothorn LA (1999) Trend tests in epidemiology: p-values or confidence intervals?,  Biometrical Journal 41(7)817-825
    DOI: 10.1002/(SICI)1521-4036(199911)41:73.0.CO;2-C
  • Koch H-F, Hothorn LA (1999) Exact unconditional distributions for dichotomous data in many-to-one comparisons,  Journal of Statistical Planning and Inference 82(1-2):83-99
    DOI: 10.1016/S0378-3758(99)00033-6
  • Neuhäuser M, Hothorn LA (1999) An exact Cochran-Armitage test for trend when dose-response shapes are a priori unknown,  Computational Statistics and Data Analysis 30(4)403-412
    DOI: 10.1016/S0167-9473(98)00091-7
  • Todt I, Ngezahayo A, Ernst A, Kolb H-A (1999) Inhibition of gap junctional coupling in cochlear supporting cells by Gentamicin,  Pflügers Arch 438:865-867
    DOI: 10.1007/s004249900109
  • Bauer P, Röhmel J, Maurer W, Hothorn LA (1998) Testing strategies in multi-dose experiments including active control,  Statistics in Medicine 17(18):2133-2146
    DOI: 10.1002/(SICI)1097-0258(19980930)17:18<2133::AID-SIM901>3.0.CO;2-2
  • Bolte R, Walz M, Lehmann KJ, Hothorn T, Brill C, Hothorn LA, Georgi M (1998) Teleradiology: results of a questionnaire of German radiologists,  Journal of Telemedicine and Telecare 4 Suppl 1:69-71
    DOI: 10.1258/1357633981931524
  • Fairweather WR, Bhattacharyya A, Ceuppens PP, Heimann G, Hothorn LA, Kodell RL, Lin KK, Mager H, Middleton BJ, Slob W, Soper KA, Stallard N, Ventre J, Wright J (1998) Biostatistical Methodology in Carcinogenicity Studies,  Drug Information Journal 32:401-421
    DOI: 10.1177/009286159803200212
  • Lalla S, Hothorn LA, Haag N, Bader R, Bauss F (1998) Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats,  Osteoporosis International 8(2):97-103
    DOI: 10.1007/BF02672503
  • Neuhäuser M, Hothorn LA (1998) An analogue of Jonckheere’s trend test for parametric and dichotomous data,  Biometrical Journal 40(1)11-19
    DOI: 10.1002/(SICI)1521-4036(199804)40:1<11::AID-BIMJ11>3.0.CO;2-0
  • Neuhäuser M, Liu P-Y, Hothorn LA (1998) Nonparametric tests for trend: Jonckheere’s test, a modification and a maximum test,  Biometrical Journal 40:899-909
    DOI: 10.1002/(SICI)1521-4036(199812)40:8<899::AID-BIMJ899>3.0.CO;2-9
  • Ngezahayo A, Zeilinger C, Todt I, Marten I, Kolb H-A (1998) Inactivation of expressed and conducting rCx46 hemichannels by phosphorylation,  Pflügers Arch 436:627-629
    DOI: 10.1007/s004240050681
  • Hothorn LA (1997) Modifications of the closure principle for analyzing toxicological studies,  Drug Information Journal 31(2)403-412
    DOI: 10.1177/009286159703100211
  • Hothorn LA, Lin KK, Hamada C, Rebel W (1997) Recommendations for Biostatistics of Repeated Toxicity Studies,  Drug Information Journal 30(2):327-334
    DOI: 10.1177/009286159703100203
  • Hothorn LA, Martin U (1997) Application of adaptive interim analysis in pharmacology,  Drug Information Journal 31(2):615-619
    DOI: 10.1177/009286159703100229
  • Hothorn LA, Neuhäuser M, Koch H-F (1997) Analysis of randomized dose-finding studies: closure test modifications based on multiple contrast tests,  Biometrical Journal 39(4)467-479
    DOI: 10.1002/bimj.4710390408
  • Kropf S, Hothorn LA, Läuter J (1997) Multivariate many-to-one procedures with applications to pre-clinical trials,  Drug Information Journal 31(2):433-447
    DOI: 10.1177/009286159703100214
  • Neuhäuser M, Hothorn LA (1997) The control of consumer’s risk in the Ames mutagenicity assay,  Drug Information Journal 31(2):363-367
    DOI: 10.1177/009286159703100207
  • Neuhäuser M, Hothorn LA (1997) Trend tests for dichotomous endpoints with application in carcinogenicity studies,  Drug Information Journal 31(2):463-469
    DOI: 10.1177/009286159703100217
  • Hauschke D, Steinjans VW, Hothorn LA (1996) A note on Welch’s approximate t-solution to bioequivalence assessment,  Biometrika 83:236-237
    DOI: 10.1093/biomet/83.1.236
  • Ngezahayo A, Lang F, Kolb H-A (1995) Cholecystokinin-octapeptide affects the fluorescence signal of a single pancreatic acinar cell loaded with the acrylodan-labelled MARCKS peptide, a protein kinase C substrate,  Pflügers Arch 429:805-808
    DOI: 10.1007/BF00374804
  • Hartmann B, Ngezahayo A, Heller B, Jalowy A, Burkart V, Kolb H-A (1994) Nitric oxide toxicity in pancreatic islet cells: role of protein biosynthesis, calcium influx and arachidonic acid metabolism,  Biochem Soc Trans 22:23-26
    DOI: 10.1042/bst0220023
  • Hothorn LA (1994) Multiple Comparisons in Long-Term Toxicity Studies,  Environmental Health Perspectives 102 Suppl 1:33-38
    DOI: 10.1289/ehp.94102s133
  • Hothorn LA (1994) Biostatistical analysis of the micronucleus mutagenicity assay based on the assumption of a mixing distribution,  Environmental Health Perspectives 102 Suppl 1:121-125
    DOI: 10.1289/ehp.94102s1121
  • Hothorn LA, Hajian G (1994) Biostatistical Aspects of Toxicokinetics,  Drug Information Journal 28:187-190
    DOI: 10.1177/009286159402800123
  • Ngezahayo A, Kolb H-A (1994) Regulation of gap junctional coupling in isolated pancreatic acinar cell pairs by cholecystokinin-octapeptide, vasoactive intestinal peptide (VIP) and a VIP-antagonist,  J Membr Biol 139:127-136
    DOI: 10.1007/BF00232431
  • Ngezahayo A, Kolb H-A (1993) Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells,  Pflügers Arch 422:413-415
    DOI: 10.1007/BF00374302
  • Hothorn LA, Lehmacher W (1991) A simple testing procedure 'control versus k treatments' for one-sided ordered alternatives,  Biometrical Journal 33(2)179-189
    DOI: 10.1002/bimj.4710330208
  • Kälble T, Tricker AR, Berger M, Amelung F, Waldherr R, Hothorn L, Möhring K, Staehler G (1991) Tumor induction in a rat model for ureterosigmoidostomy without evidence of nitrosamine formation,  Journal of Urology 146(3)862-866
    DOI: 10.1016/S0022-5347(17)37949-1
  • Solecki R, Hothorn LA, Holzweissig M, Heinrich V (1991) Computerised analysis of pathological findings in longterm trials with Phenylmeruric acetate in rats,  Archives of Toxicology Supplement 14:100-103
    DOI: 10.1007/978-3-642-74936-0_21
  • Ngezahayo A, Kolb H-A (1990) Gap junctional permeability is affected by cell volume changes and modulates volume regulation,  FEBS Lett 276:6-8
    DOI: 10.1016/0014-5793(90)80493-3
  • Hothorn LA (1989) A simple statistical procedure for testing tumour rates in animal carcinogenicity experiments,  Archives of Toxicology Supplement 13:265-268
    DOI: 10.1007/978-3-642-74117-3_47
  • Hothorn LA (1989) Robustness study on Williams and Shirley procedure, with application in toxicology,  Biometrical Journal 31(8)891-903
    DOI: 10.1002/bimj.4710310802
  • Hothorn LA (1989) On the behaviour of Fligner/Wolfe trend test 'control versus k treatments', with application in toxicology,  Biometrical Journal 31(7)767-780
    DOI: 10.1002/bimj.4710310702

Books

  • Hothorn LA (2015) Statistics in Toxicology Using R,  Chapman and Hall/CRC
    ISBN: 9781498701273 CAT# K24557
  • Hothorn LA (ed.) (1991) Modern Statistical Methods in Toxicology,  Lecture Notes in Medical Informatics, Vol. 41, Springer
  • Hothorn LA (1990) Probleme der Toxikologie Vol. 5,  Verlag Volk und Gesundheit, Berlin

Book chapters

  • Reichl FX, Schwenk M (ed) (2014) Regulatory Toxicology. Chapter: Statistical Evaluation Methods in Toxicology,  Springer Heidelberg 213-223
    DOI: 10.1007/978-3-642-35374-1_44
  • Marquardt H, Schäfer SG, Barth H (Hrsg.) (2013) Lehrbuch der Toxikologie,  Wissenschaftliche Verlagsgesellschaft Stuttgart, vollständig überarbeitete und erweiterte Auflage ISBN 978-3-8047-2876-9 darin: Biometrie
  • Lin D, Djira GD, Shkedy Z, Burzykowski T, Hothorn LA (2012) Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test,  Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R Use R!, 2012, Part 2, 249-258
  • Lin D, Hothorn LA, Djira GD, Bretz F (2012) Multiple Contrasts Test for Testing Dose-Response under Order-Restricted Alternatives,  Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R; Use R! 233-247
    DOI: 10.1007/978-3-642-24007-2_15
  • Lin D, Yekutieli D, Djira GD, Hothorn LA (2012) Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement Rate,  Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R; Use R! 259-267
    DOI: 10.1007/978-3-642-24007-2_16
  • Marquardt H, Schäfer SG (2003) Lehrbuch Toxikologie. Darin: Biostatistik,  Wissenschaftliche Verlagsgesellschaft
  • Bretz F, Hothorn LA (2001) Multiple comparisons in repeated measures designs, with biomedical applications. In: Mathematical Statistics with Applications in Biometry,  Festschrift in honour of S. Schach, eds. J. Kunert, G. Trenkler. J. Eul. Verlag Lohmar 303-312
  • Hauschke D, Hothorn LA (1998) Safety assessment in toxicology studies: proof of safety versus proof of hazard,  Chow S-C, Liu J-P (eds.): Design and analysis of animal studies in pharmaceutical development. Chapter 6. Marcel Dekker, New York, 197-226
  • Hothorn LA, Hauschke D (1998) Statistical Testing Principles in Randomized Toxicological Studies,  Chow S-C, Liu J-P (eds.): Design and analysis of animal studies in pharmaceutical development. Chapter 4. Marcel Dekker, New York, 79-134
  • Rasch D et al. (eds.) (1998) Verfahrensbibliothek Versuchsplanung und –auswertung Band II. Mitarbeit an mehreren Verfahren (Hothorn LA),  R. Oldenburg Verlag München
  • Hothorn LA (1997) New statistical methods for analyzing mutagenicity assays: real data problems in biopharmeceutical drug development,  Kitsos, C.P.; Edler, L. (eds.): Industrial statistics. Physica Verlag Heidelberg, 201-208
  • Hothorn LA, Hauschke D, Senn SJ, Lehmacher W (1997) Pro’s and con’s of cross-over trials,  Vollmar, J; Hothorn LA (Eds.) Cross-over clinical trials. Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 97
  • Hothorn LA, Hauschke D, Senn SJ, Lehmacher W (1997) Cross-over trials: references of the last six years,  Vollmar, J; Hothorn LA (Eds.) Cross-over clinical trials. Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 73-96
  • Neuhäuser M, Hothorn LA (1997) Adaptive tests for trend,  Kitsos CP, Edler L (eds.): Industrial statistics. Physica Verlag Heidelberg, 269-273.
  • Vollmar J, Hothorn LA (Eds.) (1997) Cross-over clinical trials,  Biometrics in the Pharmaceutical Industry, Volume 7, Fischer Verlag Stuttgart, 1-97
  • Hajian G, Hothorn LA (1995) Biostatistical aspects of concomitant toxicokinetics,  Vollmar J (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6, Fischer Verlag Stuttgart, 115-133
  • Hothorn LA (1995) Biostatistical analysis of the experimental design ‘control versus k treatments’ including a positive control group,  Vollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6; Fischer Verlag Stuttgart, 19-26
  • Maurer W, Hothorn LA, Lehmacher W (1995) Multiple comparisons in drug clinical trials and preclinical assays: a-priori ordered hypotheses,  Vollmar, J. (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6; Fischer Verlag Stuttgart, 3-18
  • Ortseifen C, Hothorn LA (1995) Multiple Vergleiche ‘Kontrolle gegen k Behandlungen’ bei Abweichung von den ANOVA-Annahmen,  Vollmar J (ed.) Biometrie in der chemisch-pharmazeutischen Industrie, Volume 6, Fischer Verlag Stuttgart, 77-100
  • Marquardt H, Schäfer SG (1994) Lehrbuch der Toxikologie. Darin: Biometrie,  Wissenschaftsverlag Mannheim 15-31
  • Hothorn LA (1992) Sample size estimation for several trend tests in the k-sample problem,  Computational Statistics. (Ed.: Dodge,Y. and Whittaker,J.), Physica-Verlag Heidelberg, Vol. 2; 387-390
  • Hothorn LA, Nagel M (1992) Eine Software-Umgebung zur kombinierten exploratorischen und konfirmatorischen Datenanalyse bei multivariaten Fragestellungen in präklinischen und klinischen Studien,  Methoden und Werkzeuge für die exploratorische Datenanalyse in den Biowissenschaften. G. Fischer, Stuttgart
  • Nagel M, Hothorn LA, Hartmann P (1992) Hochinteraktive Datenanalyse- Werkzeuge und Prinzipien,  Methoden und Werkzeuge für die exploratorische Datenanalyse in den Biowissenschaften. G. Fischer, Stuttgart

Conference proceedings

  • Menke S, Poehling HM, Gerhard D (2011) Application of generalized linear model based multiple comparison procedures to greenhouse pest control experiments,  Acta Horticulturae 893:1233-1238
  • Gerhard D, Schaarschmidt F (2007) Proof of safety for non-target species: a confidence interval approach. Proceedings of the International Symposium Agricultural Field Trials – Today and Tomorrow,  Stuttgart-Hohenheim: 37-43

Thesis

  • Fneish F (2018) Treatment comparisons of count data with only 0s in one treatment group, M.Sc. thesis
  • Vogel KC (2018) Simultaneous Inference for the Comparison of Overdispersed Multinomial Data, Ph.D. thesis
  • Domes HS (2016) Validity of Confidence Intervals in Case of Model Selection Uncertainty, M.Sc. Thesis | File |
  • Pallmann P (2016) Multiple Contrast Tests with Repeated and Multiple Endpoints|with Biological Applications,  Ph.D. Thesis | File |
  • Schaarschmidt F (2016) Simultane Konfidenzintervalle für multiple Vergleiche - Ansätze für nicht Gauß-verteilte Daten und Inferenz in linearen Modellen, Habil | File |
  • Kitsche A (2014) Evaluation of interaction effects in two-factorial designs by simultaneous confidence intervals in the cell means model,  Ph.D. Thesis | File |
  • Gerhard D (2010) Simultaneous small sample inference based on profile likelihood,  Ph.D. Thesis | File |
  • Scherer R (2010) Simultaneous Confidence Intervals for Biodiversity Indices with Application to Overdispersed Multinomial Count Data,  M.Sc. Thesis | File |
  • Schmidt M (2010) Multiple comparisons of populations based on genetic marker data,  M.Sc. Thesis | File |
  • Hasler M (2009) Extensions of Multiple Contrast Tests,  Ph.D. Thesis | File |
  • Mi X (2009) Model Selection Procedure with Familywise Error Rate Control for Binomial Order-Restricted Problems,  Ph.D. Thesis | File |
  • Schaarschmidt F (2009) Marginal and simultaneous confidence intervals for abundance data with applications to safety assessment of non-target species,  Ph.D. Thesis | File |
  • Menke S (2008) Einfluss von Neem Azal-U und Neem-Pellet auf Trialeurodes vaporariorum und Encarsia formosa unter besonderer Berücksichtigung der biostatistischen Bewertung der Versuchsdaten mittels Generalisierter Linearer Modelle,  M.Sc Thesis | File |
  • Frömke C (2006) Relevance-shifted tests for high dimensional data with small sample sizes,  Ph.D. Thesis | File |
  • Gerhard D (2006) Poisson confidence intervals for testing the equality of abundance data in generalized linear models,  Diplomarbeit | File |
  • Dilba G (2005) Simultaneous Inference for Ratios of Location Parameters,  Ph.D. Thesis | File |
  • Schaarschmidt F (2005) Binomial group testing – Design and Analysis,  Diplomarbeit | File |
  • Ma D (2004) Small Sample Inference For The Two-Sample Design,  M.Sc. Thesis | File |
  • Bretz F (2003) Planung und Auswertung von Dosis-Wirkungs-Studien unter Verwendung von multiplen Testprozeduren,  Ph.D. Thesis | File |
  • Biesheuvel E (2002) Many-to-one comparisons in stratified designs,  Ph.D. Thesis | File |
  • Frömke C (2001) Simultaneous tests and confidence intervals for experimental agricultural designs,  Diplomarbeit | File |
  • Seidel D (2000) Trendtests für geordnete kategoriale Daten bei sehr kleinen Fallzahlen,  Ph.D. Thesis | File |
  • Bretz F (1999) Powerful Modifications of Williams' Test on Trend,  Ph.D. Thesis | File |
  • Hauschke D (1999) Biometrische Methoden zur Planung und Auswertung von Sicherheitsstudien,  Ph.D. Thesis | File |

Reports

  • Schaarschmidt F, Hothorn LA (2014) Simple prediction intervals for one future observation for simple, balanced random effects models | File |
  • Hasler M (2010) Multiple contrast tests for multiple endpoints | File |
  • Hasler M (2008) Equivalence for multiple endpoints | File |
  • Hasler M (2008) Robustness simulation study for continuous endpoints in one-way-layouts | File |
  • Hasler M (2008) Equivalence with respect to a control | File |
  • Schaarschmidt F (2008) Properties of confidence intervals for the comparison of small binomial proportions when sample sizes are large | File |
  • Gerhard D (2007) CI for Odds Ratios accounting for Extra Variation between Replicated Experiments | File |
  • Hasler M (2007) IUT for multiple endpoints | File |
  • Schaarschmidt F (2007) Confidence intervals for the proof of safety for abundance data | File |
  • Schaarschmidt F (2007) Confidence intervals and limits for the risk ratio revisited | File |
  • Schaarschmidt F (2007) Confidence intervals for the ratio of means of two normal distributed populations in the presence of heteroscedasticity | File |
  • Sill M (2007) Approximate one-sided two-sample confidence limits for the comparison of a treatment versus a near-zero spontaneous rate in control | File |
  • Sill M, Schaarschmidt F (2007) Approximate simultaneous confidence intervals for the evaluation of long term carcinogenicity trials | File |
  • Sill M, Schaarschmidt F (2007) Approximate simultaneous confidence intervals and tests for proportions using multiple Williams contrasts | File |
  • Hothorn LA, Vaeth M, Hothorn T (2003) T. TREND TESTS FOR THE EVALUATION OF DOSE-RESPONSE RELATIONSHIPS IN EPIDEMIOLOGICAL EXPOSURE STUDIES | File |

Last Change: 17.07.19; Clemens Buczilowski Print

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